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Molecular docking-based test for affinities of two ligands toward vasopressin and oxytocin receptors

100%

Slusarz R., Kazmierkiewicz R., Gieldon A., Lammek B., Ciarkowski J.

Acta Biochimica Polonica

2001

tom 48

nr 1

Molecular docking simulations are now fast developing area of research. In this work we describe an effective procedure of preparation of the receptor-ligand complexes. The amino-acid residues involved in ligand binding were identified and described.

Anti-inflammatory effects of nesfatin-1 in rats with acetic acid - induced colitis and underlying mechanisms

84%

Ozturk C. C., Oktay S., Yuksel M., Akakin D., Yarat A., Kasimay Cakir O.

Journal of Physiology and Pharmacology

2015

tom 66

nr 5

Molecular modelling study of the role of cholesterol in the stimulation of the oxytocin receptor

84%

Politowska E., Kazmierkiewicz R., Wiegand V., Fahrenholz F., Ciarkowski J.

Acta Biochimica Polonica

2001

tom 48

nr 1

Cholesterol, an integral component of membranes in Eucaryota, is a modifier of membrane properties. In vivo studies have demonstrated that cholesterol can also modulate activities of some G protein-coupled receptors (GPCRs), which are integral membrane proteins. This can result either from an effect of cholesterol on the membrane fluidity or from specific interactions of the membrane cholesterol with the receptor, as recently demonstrated for the cholecystokinin type β (CCKRβ ) or the oxytocin receptor (OTR). Using molecular modelling, we studied conformational preferences of cholesterol and several of its analogues. Subsequently, we simulated the distributions of their preferred conformations around the surface of OTR, CCKR β and a chimeric oxytocin/cholecystokinin receptor. Consequently, we suggest residues on the surface of OTR which are potentially significant in the OTR/cholesterol interaction.

Ograniczanie wyników

2 Acta Biochimica Polonica

1 Journal of Physiology and Pharmacology

2 Ciarkowski J.

2 Kazmierkiewicz R.

1 Akakin D.

1 Fahrenholz F.

1 Gieldon A.

1 Kasimay Cakir O.

1 Lammek B.

1 Oktay S.

1 Ozturk C. C.

1 Politowska E.

1 Slusarz R.

1 Wiegand V.

1 Yarat A.

1 Yuksel M.

1 2015

2 2001

Wyniki wyszukiwania

Molecular docking-based test for affinities of two ligands toward vasopressin and oxytocin receptors

Anti-inflammatory effects of nesfatin-1 in rats with acetic acid - induced colitis and underlying mechanisms

Molecular modelling study of the role of cholesterol in the stimulation of the oxytocin receptor