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The influence of doxycycline on articular cartilage in experimental osteoarthrosis induced by iodoacetate

100%

Cylwik J., Kita K., Barwijuk-Machala M., Reszec J., Klimiuk P., Sierakowski S., Sulkowski S.

Folia Morphologica

2004

tom 63

nr 2

The experiment was performed on 36 Wistar rats. On the first day of the experiment iodoacetate was administered to the left posterior knee joint of the 18 rats which composed Group I. The second group of 18 rats received additionally doxycycline (doxy) through the gastric tube in doses comparable with those of doxycycline used in humans. The experiment lasted 21 days. The animals were sacrificed after 7, 14 and 21 days in groups of 6 rats each. In sections stained with Safranin 0 semiquantitative histochemical intensity tests were performed on articular cartilage glycosaminoglycans (GAG) using a four-point scale (0–3). In the first group examined destructive lesions in the articular cartilage and weak reactivity on GAG were noted at all stages of the experiment. The intensity of GAG staining was higher in the second group after 14 and especially after 21 days, which may suggest a protective action of doxy on articular cartilage.

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Influence of modified trandermal hormone replacement therapy including magnesium, on bone formation markers with osteoarthrosis of spine in women

84%

Stanosz M., Stanosz S., Puchalski A.

Journal of Elementology

2009

tom 14

nr 2

365-372

In a randomized study 50 women, aged 51.7±2.8 years, suffering from primary osteoarthrosis (OA), were divided into two, equal groups (I, II). The women were employed in garment industry in contract work system. They were working in compulsory, mainly standing position. The women complained of backache of the lumbar region continuing for the minimum 5 years. During the study, bone mineral density (BMD) of the lumbar spine was assessed twice with the densitometry DEXA method (Lunar Corporation equipment). Before treatment, structural changes in the lumbosacral spine were revealed using a CT Simens Sonata Plus 4. One energy technique (SEQCT) was applied. Concentrations of bone-forming markers in serum were measured three times: before treatment and 3 and 12 months afterwards. The concentration of acid phosphatase in serum was assessed by the enzymatic method according to Hitachi. The concentrations of osteocalcin and procolagen were radoimmunologically assessed by means of DRG Company – sets and concentration basal prolactin (PRL) before treatment radioimmunoassy kits produced by bioMerieux. In the first stage of the treatment, the women in the first group received placebo for three months. Slow Mag B6 was administered for three months to the women in the second group. In the second stage of the treatment, the women in both groups received 21-day therapeutic cycles of modified transdermal hormonal replacement therapy. Additionally, bromocriptine (2.5 mg per day) and Slow Mag B6 (160 mg per day) were administered orally. The cycles repeated at a 7-day interval. During the interval, withdrawal bleeding occurred. The results were statistically assessed by means of computerized programme package Statistica PL, version 5. It was stated that in 60% of women suffering from primary OA the basal concentration of prolactin in serum in was elevated above 25 ng/ml; in 25% women it was on the border level, and in 15% of the patients it was below the lower limit of the normal values. The combined treatment in women suffering from OA caused increase in bone-forming markers and decrease in pathological resorption processes of mineralization of the vertebral bodies. After 12 months of the therapy, resorption in the lumbar spine was diminished compared to the initial values, before the treatment. These changes were significant in L3/L4 vertebral bodies (p<0.05).

Ograniczanie wyników

1 Folia Morphologica

1 Journal of Elementology

1 Barwijuk-Machala M.

1 Cylwik J.

1 Kita K.

1 Klimiuk P.

1 Puchalski A.

1 Reszec J.

1 Sierakowski S.

1 Stanosz M.

1 Stanosz S.

1 Sulkowski S.

1 2009

1 2004

Wyniki wyszukiwania

The influence of doxycycline on articular cartilage in experimental osteoarthrosis induced by iodoacetate

Influence of modified trandermal hormone replacement therapy including magnesium, on bone formation markers with osteoarthrosis of spine in women