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Influence of multiple endotoxin injections on Fe, Zn and Cu concentrations in blood serum in horses

100%

Krumrych W., Wisniewski E., Danek J., Gehrke M.

Bulletin of the Veterinary Institute in Puławy

2001

tom 45

nr 2

The aim of the study was to evaluate the Fe, Zn and Cu concentration changes in the course of endotoxin tolerance in horses. The study involved 8 clinically healthy mares subjected to 4 iv. injections with 0.1 μg/kg b.w. of LPS from E.coli - three times at 24 hour intervals (LPS-1, LPS-2, LPS-3) and one injection a week after the last injection (LPS-4). Rectal temperature measurements and blood sampling for testing were performed before each LPS administration as well as 1h, 2h, 3h, 5h and 7h thereafter. It has been found that administration of a relatively small dose of endotoxin produced not only a rise in body temperature but also a significant decrease in Fe and Zn concentration in serum. Subsequent injections (LPS-2 and LPS-3) did not result in significant changes of concentration of these elements, which suggests that endotoxin tolerance mechanisms had been switched on. It has been demonstrated that this process does not last longer than one week because LPS-4 administration resulted in renewed decrease of Fe and Zn concentrations. However, no significant influence of endotoxin injection on Cu content in serum was found.

Nutritional immunity in horses

80%

Wisniewski E., Danek J., Krumrych W., Lachowski A.

Bulletin of the Veterinary Institute in Puławy

1993

tom 37

nr 1

Ograniczanie wyników

2 Bulletin of the Veterinary Institute in Puławy

2 Danek J.

2 Krumrych W.

2 Wisniewski E.

1 Gehrke M.

1 Lachowski A.

1 2001

1 1993

Wyniki wyszukiwania

Influence of multiple endotoxin injections on Fe, Zn and Cu concentrations in blood serum in horses

Nutritional immunity in horses