Wyniki wyszukiwania

1

Protective effects of nicotine against glutamate-induced neurotoxicity in PC12 cells

100%

Sun X., Liu Y., Hu G., Wang H.

Cellular and Molecular Biology Letters

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2004

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tom 09

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nr 3

This study aimed to assess whether nicotine prevented glutamate neurotoxicity in PC12 cells, and to identify the molecular mechanisms of any effects. The results showed that glutamate neurotoxicity in PC12 cells could be prevented by treatment with nicotine at concentrations of 10 nmol.l-1-1 mmol.l-1. This effect was in turn found to be inhibited by the application of the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine. Nicotine significantly decreased the basal level of intracellular free Ca2+ and enhanced the buffering action on Ca2+ overload induced by high concentrations of glutamate (5 mmol.l-1). In addition, nicotine treatment up-regulated the mRNA and protein expression of apoptosis-related factors including bcl-2 mRNA and protein, but down-regulated the expression of bax mRNA and protein. It is concluded that the protective effects of nicotine against the neurotoxicity induced by glutamate are mediated by nAChRs, due to the increased buffering action on Ca2+ and the modulation of apoptotic processes.

2

Role of nitric oxide in the nicotine-induced pituitary-adrenocortical response

100%

Gadek-Michalska A., Bugajski J.

Journal of Physiology and Pharmacology

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2004

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tom 55

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nr 2

Nitric oxide (NO) is a major signaling molecule and biological mediator of the hypothalamic-pituitary-adrenal (HPA) axis. We investigated the role of NO formed by endothelial (e), neuronal (n) and inducible (i) nitric oxide synthase (NOS) in the stimulatory effect of nicotine on the HPA axis in rats under basal conditions. Also possible interaction of NOS systems with endogenous prostaglandins (PG) in that stimulation was assessed. NOS and cyclooxygenase inhibitors were administered i.p. 15 min prior to nicotine (2, 5 mg/kg i.p.). Plasma ACTH and serum corticosterone levels were measured 1 h after nicotine injection. NOS blockers given alone did not markedly affect the resting ACTH and corticosterone levels. L-NAME (2-10 mg/kg), a broad spectrum NOS inhibitor considerably and dose dependently enhanced the nicotine-induced ACTH and corticosterone secretion. L-NNA (2 mg/kg) and 7-nitroindazole (7-NI 20 mg/kg), neuronal NOS inhibitors in vivo also significantly augmented the nicotine-induced ACTH and corticosterone levels. L-arginine greately impaired the nicotine-induced hormone responses and reversed the L-NNA elicited enhancement of the nicotine-evoked ACTH and corticosterone response. In contrast to the constitutive eNOS and nNOS antagonists, an inducible NOS antagonist guanethidine (50-100 mg/kg i.p.) did not substantially affect the nicotine-elicited pituitary-adrenocortical responses. Indomethacin (2 mg/kg i.p.), a non-selective cyclooxygenase blocker abolished the L-NAME and L-NNA-induced enhancement of the nicotine-evoked ACTH and corticosterone response. These results indicate that NO is an inhibitory mediator in the HPA axis activity. Inhibition of its generation by eNOS and nNOS significantly enhances the nicotine-induced HPA response. Under basal conditions iNOS is not involved in the nicotine-induced ACTH and corticosterone secretion. Prostaglandins play an obligatory role in the response of HPA axis to systemic nicotine administration.

3

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Effects of nicotine on the concentration of native and cryptic Met- and Leu-enkephalin in peripheral tissues

100%

Pierzchala-Koziec K., Van Loon G. R.

Journal of Physiology and Pharmacology

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1994

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tom 45

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nr 2

4

Association of occupational stress factors on nicotine dependence among patients visiting dental care unit of Indo-Tibetian border police force station in India

86%

Karandeep Singh Sandhu K. S., Vikram Arora V., Gupta N., Gupta P., Mitali Raja M., Nishant Mehta N.

Roczniki Państwowego Zakładu Higieny

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2016

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tom 67

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nr 1

Background. Tobacco use is the foremost preventable cause of death and disease in the world today and work strain might be related with nicotine dependence by its provoking effect. Objective. To assess the association between occupational stress and nicotine dependence. Material and methods. A cross sectional survey was conducted among 200 subjects visiting a satellite dental clinic of Swami Devi Dyal Hospital and Dental College, Barwala, Panchkula, India. Nicotine dependence was measured using the Fagerstrom Test for Nicotine Dependence (FTND). The extent of the stress factors experienced at work was assessed using the Effort-Reward Imbalance scale (ERI). Chi-square test and multiple logistic regression analysis were employed for statistical analysis. Confidence level and level of significance were set at 95% and 5% respectively. Results. The results of bivariate analysis revealed association of occupational stress with age, marital status, educational status, level of nicotine dependence, frequency of cigarette smoking and religious attendance. However, multivariate analysis elicited the significant association of occupational stress with only two variables, level of nicotine dependence and frequency of smoking. Conclusion. Occupational stress was found to be associated with nicotine dependence in the present study implying a need of other tranquil measures to be incorporated for the relief of work related stress.

5

Papieros przed sniadaniem

86%

Kolodziejczyk M.

Żywność, Żywienie, Życie. Szkoła Główna Gospodarstwa Wiejskiego w Warszawie

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2002

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nr 1

38-39

6

Average quantitative concentration of cotinine within the system pregnant woman-baby

86%

Dobek D., Karmowski A., Sobiech K. A., Terpilowski L., Mis-Michalek M.

Archivum Immunologiae et Therapiae Experimentalis

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1998

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tom 46

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nr 1

7

Differential effects of nicotine on the activity of substantia nigra and ventral tegmental area dopaminergic neurons in vitro

86%

Teo M. Y., Van Wyk M., Lin J., Lipski J.

Acta Neurobiologiae Experimentalis

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2004

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tom 64

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nr 2

8

Effect of adrenergic antagonists and cyclooxygenase inhibitors on the nicotine-induced hypothalamic-pituitary-adrenocortical activity

86%

Gadek-Michalska A., Bugajski J., Bugajski A. J., Glod R.

Journal of Physiology and Pharmacology

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2002

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tom 53

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nr 2

Nicotine is a potent stimulus for the hypothalamic-pituitary-adrenal (HPA) axis. Systemic nicotine acts via central mechanisms to stimulate by multiple pathways the release of ACTH from the anterior pituitary corticotrops and corticosterone from the adrenal cortex. Nicotine may stimulate indirectly the hypothalamic paraventricular nucleus, the site of the corticotropin-releasing hormone (CRH) neurons which activates ACTH release. In the present studies an involvement of adrenergic system and prostaglandins synthesized by constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2) in the nicotine-induced HPA response in rats was investigated. Nicotine (2.5-5 mg/kg i.p.) significantly increased plasma ACTH and corticosterone levels measured 1 hr after administration. Adrenergic receptor antagonists or COX inhibitors were injected i.p. 15 min prior to nicotine and the rats were decapitated 1 hr after the last injection. Prazosin (0.01-0.1 mg/kg), an alpha1-adrenergic antagonist, significantly decreased the nicotine-evoked ACTH and corticosterone secretion. Yohimbine (0.1-1.0 mg/kg), an alpha2-adrenergic antagonist, moderately diminished ACTH response, and propranolol (0.1-10 mg/kg), a ß-adrenergic antagonist, did not significantly alter the nicotine-induced hormones secretion. Pretreatment with piroxicam (0.2-2.0 mg/kg), a COX-1 inhibitor, considerably impaired the nicotine-induced ACTH and corticosterone secretion. Compound NS-398 (0.2-5.0 mg/kg), a selective COX-2 blocker did not markedly alter these hormones secretion, and indomethacin (2 mg/kg), a non-selective COX inhibitor significantly diminished ACTH response. These results indicate that systemic nicotine stimulates the HPA axis indirectly, and both adrenergic system and prostaglandins are significantly involved in this stimulation. Noradrenaline, stimulating postsynaptic aplha1-adrenergic receptors, and prostaglandins, synthesized by COX-1 isoenzyme, are of crucial significance in the nicotine-induced ACTH and corticosterone secretion.

9

Tobacco smokers and electronic cigarettes users among Polish universities students

72%

Zarobkiewicz M. K., Wawryk-Gawda E., Wozniakowski M. M., Slawinski M. A., Jodlowska-Jedrych B.

Roczniki Państwowego Zakładu Higieny

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2016

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tom 67

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nr 1

Background. Electronic cigarettes (e-cigarettes) are small battery-powered electronic devices, heating the liquid to produce vapour – in most cases the latter contains nicotine and several flavourings. E-cigarettes are highly advertised across the media, mainly as healthy substitute to conventional cigarettes, aid in quitting smoking addiction or way of circumventing ban on smoking in public places. Objective. The aim of study was obtaining epidemiological data on cigarette smoking and electronic cigarette usage among Polish universities students. Material and methods. Students of different Polish state universities were asked to fill a self-prepared survey on cigarettesmoking and electronic cigarette usage. 1068 fulfilled questionnaires were gathered. The population was divided into two subgroups – medical universities’ students (n=545) and non-medical universities students (n=523). Results. 23.78% of respondents declared current smoking while 57.0% admitted ever smoking. The mean duration of smoking among current smokers was 4.17 ± 2.53 years. 56.30% of current smokers tried quitting at least once. 31.46% of students declared ever using e-cigarettes (37.28% (n=195) among non-medical universities’ students and 25.87% (n=141) among medical universities’ students and 8.33% current usage. Among the latter 52.81% admitted simultaneous smoking. 26.97% of current e-cigarettes’ users declared having experienced side effects of e-cigarettes. 42.70% (n=456) of respondents viewed e-cigarettes as safer than conventional cigarettes, this group comprises of 40.54% (n=212) non-medical and 44.77% (n=244) medical universities’ students. 85.39% (n=912) of students viewed e-cigarettes as generally unhealthy, there were 83.56% (n=437) non-medical and 87.16% (n=475) medical universities’ students among this group. Conclusions. The frequency of e-cigarettes usage resembles current status in many Western countries. Collected data shows high frequency of e-cigarettes usage and conventional cigarettes smoking among students (also medical universities’ students). The situation requires intensive preventive measures to limit and reduce the popularity of tobacco products along with modern equivalents like electronic cigarettes.

10

Effects of the cannabinoid receptor ligands on anxiety-related effects of D-amphetamine and nicotine in the mouse elevated plus maze test

72%

Biala G., Kruk M., Budzynska B.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 2

113-122

The purpose of the experiments was to examine the anxiety-related effects of d-amphetamine and nicotine, and the possible involvement of the endocannabinoid system. D-amphetamine (2 mg/kg, ip) was administered acutely or daily for 8 days. On the 9th day, mice were challenged with d-amphetamine (2 mg/kg, ip) or nicotine (0.1 mg/kg, sc), and were tested in the elevated plus maze. Additionally, a distinct group of mice was pretreated with an acute (0.1 mg/kg, sc) or subchronic nicotine (6 days), and subjected to nicotine (0.1 mg/kg, sc) or d-amphetamine (2 mg/kg, ip) challenge on the 7th day. The cannabinoid receptor ligands, WIN 55,212-2, a non-selective cannabinoid receptor agonist (0.25; 0.5 and 1 mg/kg, ip) and rimonabant, a CB1 cannabinoid receptor antagonist (0.25; 0.5; 1 and 2 mg/kg, ip) were injected prior to each injection of saline or acute and subchronic d-amphetamine or nicotine. We observed that acute anxiogenic and subchronic anxiolytic effects of both psychostimulants as well as the development of full cross-tolerance to their anxiogenic effects were dose-dependently blunted by ineffective doses of WIN 55,212-2 (0.25 and 0.5 mg/kg) and rimonabant (0.5 and 1 mg/kg). These results provide evidence that the endogenous cannabinoid system is involved in the anxiety-related responses to d-amphetamine and/or nicotine.

11

Beta2-containing nicotinic receptor of the ventral tegmental area crucial for acquisition of nicotine self-administration but not for nicotine withdrawal syndrome

72%

Besson M., Molles B., Suarez S., Pons S., Cormier A., David V., Cazala P., Maskos U., Changeux J. P., Granon S.

Acta Neurobiologiae Experimentalis

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2005

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tom 65

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nr 5

12

Wskazniki narazenia na dym tytoniowy

72%

Moniczewski A.

Bromatologia i Chemia Toksykologiczna

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2003

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tom 36

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nr 2

167-175

13

Entamoeba histolytica L220 induces the in vitro activation of macrophages and neutrophils and is modulated by neurotransmitters

72%

Villalobos-Gomez F. R., Garcia-Lorenzana M., Escobedo C., Talamas-Rohana P., Salinas-Gutierrez R., Hernandez-Ramirez V.-I., Sanchez-Aleman E., Campos-Esparza M. R., Munoz-Ortega M. H., Ventura-Juarez J.

Acta Parasitologica

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2018

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tom 63

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nr 2

14

Contemporary trends in development of active substances possessing the pesticidal properties: neonicotinoid insecticides

72%

Legocki J., Polec I.

Pestycydy

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2008

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nr 1-2

143-159

A new group of insecticides, widely introduced to the agriculture practice since the 90-ies of XX century - neonicotinoides, is discussed. The history of its arise, and insecticidal properties, mode of action, and short characteristics of some of its representatives is presented.

15

Combined SPE and HPTLC as a screening assay of urinary cotinine from male adolescents exposed to environmental tobacco smoke

72%

Bazylak G., Brozik H., Sabanty W.

Polish Journal of Environmental Studies

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2000

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tom 09

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nr 2

Cotinine, as the main metabolite of nicotine, has been determined in urine using solid-phase extraction and the high-performance thin-layer chromatographic (SPE-HPTLC) method. The urine samples were collected from a group of 35 male adolescents which were moderate or significantly exposed to home environmental tobacco smoke (ETS). l-methyl-2-pyrrolidinone was used as the internal standard in the proposed screening procedure. The thin-layer chromatograms were evaluated densitometrically after visualization of cotinine spots with ninhydrin and cadmium acetate solution. The described SPE-HPTLC procedure indicated good selectivity, sensitivity and reproducibility, enabling reliable verification of interview collected questionnaire data in families exhibiting a diversified level of ETS. The results of cotinine measurements by the proposed method were applied for assessment of hazards from home ETS on the health status of elementary schoolboys, especially an increased risk for infectious respiratory tract diseases and exercise-induced bronchospasm.

16

The effects of nicotine in combination with antidopaminergic drugs on the maturational gonadotropin [GTH2] secretion from perifused common carp [Cyprinus carpio L.] pituitary glands

72%

Mikolajczyk T., Epler P., Sokolowska-Mikolajczyk M., Breton B., Chyb J., Cwioro E.

Polskie Archiwum Hydrobiologii

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1996

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tom 43

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nr 3

17

Apnoeic responses to intracarotid nicotine challenge in anaesthetized cats

72%

Szereda-Przestaszewska M., Kopczynska B.

Journal of Physiology and Pharmacology

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2003

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tom 54

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nr 2

To determine the effects of an intraarterial administration of nicotine on the occurrence of apnoea and the activity of rib cage respiratory muscles, we studied 31 anaesthetized, spontaneously breathing cats. Phrenic activity was used as an index of neural inspiratory drive. Activity of parasternal intercostal (PIM) and triangularis sterni (TS) muscles was recorded. Nicotine in a dose of 65 µg/kg was injected into the left common carotid artery prior to and after midcervical vagotomy, preceded by section of the superior laryngeal nerves (SLNs). In eight additional cats, initially neurotomized as mentioned, nicotine was injected after bilateral disruption of the carotid sinus nerves (CSNs). Nicotine induced prompt expiratory apnoea of mean duration of 5.4±0.3 s in 19 non-vagotomized and of 5.92±0.51 s (mean±S.E.M.) in 13 vagotomized cats. The occurrence and duration of the temporary arrest of breathing were reduced by midcervical vagotomy but not by subsequent CSNs neurotomy, which abolished post-apnoeic acceleration of breathing.In post-nicotine breathing of increased tidal volume and respiratory rate, peak activity of the parasternal intercostal muscles increased from baseline of 3.2±1.2 to 9.5±2.0 arbitrary units (p<0.001). The peak height of the phrenic nerve elevated from 7.9±0.9 to 14.5±1.7 arbitrary units (p<0.001). That of the triangularis sterni showed no change.The response of the respiratory effectors elicited by nicotine was independent of the vagal integrity and may be attributed to activation of nicotine receptors within the brainstem respiratory neurones.

18

Involvement of prostaglandins in the nicotine-induced pituitary-adrenocortical response during social stress

72%

Bugajski J., Gadek-Michalska A., Bugajski A. J.

Journal of Physiology and Pharmacology

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2002

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tom 53

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nr 4,2

The present study examined the functional selectivity of nicotine for nicotinic acetylcholine receptors in the stimulation of the hypothalamic-pituitary-adrenal (HPA) axis, the effect of social crowding stress on HPA response to nicotine and the involvement of prostaglandins synthesized by constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2) in the nicotine-induced HPA response in rats crowded (24 per a box instead 7) for 7 days. Nicotine (2.5-5.0 mg/kg i.p.) significantly increased plasma ACTH and corticosterone levels measured 1 h after administration. Mecamylamine (50 mg i.c.v.), a selective nicotinic receptor antagonist, atropine (0.1 mg/kg i.p.) a non-selective cholinergic receptor antagonist, or COX inhibitors were injected 15 min prior to nicotine and the rats were decapitated 1 h after the last injection. Mecamylamine abolished the nicotine-induced ACTH response and significantly diminished corticosterone response. Atropine did not alter ACTH response and modestly diminished corticosterone response to nicotine. Crowding stress significantly impaired the nicotine-evoked ACTH and corticosterone secretion. Pretreatment with piroxicam (0.2-2.0 mg/kg), a COX-1 inhibitor, considerably diminished the nicotine-induced ACTH and corticosterone secretion in control and crowded rats. Compound NS-398 (0.2-5.0 mg/kg), a selective COX-2 blocker, did not markedly alter the nicotine-induced hormones secretion in either control or stressed rats. Indomethacin (2 mg/kg), a non-selective COX inhibitor diminished significantly, but to a lesser extent than piroxicam, the nicotine-stimulated ACTH and corticosterone response. These results indicate that systemic nicotine stimulates the HPA axis selectively via nicotinic acetylcholine receptors. Chronic social stress significantly impairs the nicotine stimulated ACTH and corticosterone secretion. Prostaglandins, generated by COX-1- but not by COX-2- isoenzyme, are of crucial significance in the nicotine-induced ACTH and corticosterone secretion in both control and stressed rats.

19

Diverging respiratory effects of serotonin and nicotine in vagotomised cats prior to and after section of carotid sinus nerves

72%

Szereda-Przestaszewska M., Kopczynska B., Kaczynska K., Chrapusta S. J.

Journal of Physiology and Pharmacology

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2001

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tom 52

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nr 1

20

Nicotine affects behaviour, morphology and cortical cytoskeleton of Amoeba proteus

72%

Pomorski P., Wasik A., Kolodziejczyk J., Grebecka L., Klopocka W.

Acta Protozoologica

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2004

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tom 43

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nr 2

Ograniczanie wyników

Protective effects of nicotine against glutamate-induced neurotoxicity in PC12 cells

Role of nitric oxide in the nicotine-induced pituitary-adrenocortical response

Effects of nicotine on the concentration of native and cryptic Met- and Leu-enkephalin in peripheral tissues

Association of occupational stress factors on nicotine dependence among patients visiting dental care unit of Indo-Tibetian border police force station in India

Papieros przed sniadaniem

Average quantitative concentration of cotinine within the system pregnant woman-baby

Differential effects of nicotine on the activity of substantia nigra and ventral tegmental area dopaminergic neurons in vitro

Effect of adrenergic antagonists and cyclooxygenase inhibitors on the nicotine-induced hypothalamic-pituitary-adrenocortical activity

Tobacco smokers and electronic cigarettes users among Polish universities students

Effects of the cannabinoid receptor ligands on anxiety-related effects of D-amphetamine and nicotine in the mouse elevated plus maze test

Beta2-containing nicotinic receptor of the ventral tegmental area crucial for acquisition of nicotine self-administration but not for nicotine withdrawal syndrome

Wskazniki narazenia na dym tytoniowy

Entamoeba histolytica L220 induces the in vitro activation of macrophages and neutrophils and is modulated by neurotransmitters

Contemporary trends in development of active substances possessing the pesticidal properties: neonicotinoid insecticides

Combined SPE and HPTLC as a screening assay of urinary cotinine from male adolescents exposed to environmental tobacco smoke

The effects of nicotine in combination with antidopaminergic drugs on the maturational gonadotropin [GTH2] secretion from perifused common carp [Cyprinus carpio L.] pituitary glands