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The impact of nickel on human health

100%

Duda-Chodak A., Blaszczyk U.

Journal of Elementology

2008

tom 13

nr 4

685-693

In 2008, nickel received the shameful name of the “Allergen of the Year.” According to dermatologists the frequency of nickel allergies is still growing, and it cannot be explained only by fashionable piercing and nickel devices used in medicine (like coronary stents). Occupational exposure of several million workers worldwide has been shown to give rise to elevated levels of nickel in blood, urine and body tissues. In these cases, workers are exposed to airborne fumes and dusts containing nickel and its compounds and therefore inhalation is the main route of uptake. Nonoccupational sources of nickel exposure for the general population include mainly drinking water and food. Recently, tests of kitchen kettles showed substantial leaching of nickel into drinking water when boiled in kettles with exposed nickel-plated elements. Three types of adverse health impacts as a result of exposure to nickel are discussed in the text. Acute health effects generally result from short-term exposure to high concentrations of pollutants. Chronic noncancer health effects may result from long-term exposure to relatively low concentrations of pollutants. Inhalation of nickel also can cause cancer of the lungs, nose and sinuses. Cancers of the throat and stomach have also been attributed to inhalation of nickel. However, the exact mechanism by which nickel causes cancer is still questionable and needs further investigation. The most popular hypotheses to explain this phenomenon are presented in the text.

Effect of nickel [II] chloride oral exposure on urinary nickel excretion and some other elements

80%

Janicka K., Cempel M.

Polish Journal of Environmental Studies

2003

tom 12

nr 5

Male Wistar rats were given nickel (II) chloride (NiCl2 • 6 H2O) with drinking water (300 or 1200 ppm Ni for 90 days). Urine volume and nickel, zinc, copper, calcium and inorganic phosphorus were measured in 24 h urine after 45 and 90 days of exposure. The results demonstrate that relatively low-level oral exposure (300 ppm Ni) induces an increase of urinary Ni excretion (p < 0.001), but no significant changes in other elements. The higher Ni dose (1200 ppm) caused elevation of this metal in urine (p < 0.001), as well as significant changes of urinary volume, and zinc, copper and inorganic phosphorus concentration.

Ograniczanie wyników

1 Journal of Elementology

1 Polish Journal of Environmental Studies

1 Blaszczyk U.

1 Cempel M.

1 Duda-Chodak A.

1 Janicka K.

1 2008

1 2003

Wyniki wyszukiwania

The impact of nickel on human health

Effect of nickel [II] chloride oral exposure on urinary nickel excretion and some other elements