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New approaches for Helicobacter vaccine development - difficulties and progress

100%

Jagusztyn-Krynicka E. K., Godlewska R.

Polish Journal of Microbiology

2008

tom 57

nr 1

Despite the enormous progress in understanding the process of bacterial pathogenesis and interactions of pathogens with eucaryotic cells the infectious diseases still remain the main cause of human premature deaths. It is now recognized that Helicobacter pylori infects about half of the world's population. Based on results of clinical studies the World Health Organization has assigned H. pylori as a class I carcinogen. The review presents new achievements aimed at construction efficient and safe anti-Helicobacter vaccine. We discuss the new global technologies such as immunoproteomics employed for selecting new candidates for vaccine construction as well as new vaccine delivery systems. The review presents also our knowledge concerning H. pylori interaction with immune system which might facilitate modulation of the host immune system by specific adjuvant included into vaccine.

Impact of proteomics on anti-Mycobacterium tuberculosis [MTB] vaccine development

84%

Jagusztyn-Krynicka E. K., Roszczenko P., Grabowska A.

Polish Journal of Microbiology

2009

tom 58

nr 4

281-287

Tuberculosis is a serious infection disease which causes more than two million deaths annually. The TB pandemic has continued despite widespread use of the only available licensed TB vaccine - Bacillus Calmette-Guerin (BCG). Additionally, the increasing incidences of multidrug resistant strains and coinfection with HIV mean that tuberculosis constitutes a growing global threat. Thus, improvement of the vaccination strategy against TB is an urgent need, requiring international cooperation of the research community. The completion of many mycobacterial genome sequences has greatly facilitated the global analysis at the transcriptome and proteome level. This in consequence has accelerated progress in the vaccinology field resulting in identification of a large numbers of antigens with potential in TB vaccines. This review concentrates on the proteomic contribution to TB vaccinology. At the end of the article some recent achievements of structural proteomics and developing an epitope-driven tuberculosis vaccine are presented.

Ograniczanie wyników

2 Polish Journal of Microbiology

2 Jagusztyn-Krynicka E. K.

1 Godlewska R.

1 Grabowska A.

1 Roszczenko P.

1 2009

1 2008

Wyniki wyszukiwania

New approaches for Helicobacter vaccine development - difficulties and progress

Impact of proteomics on anti-Mycobacterium tuberculosis [MTB] vaccine development