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Neurotoxic action of 6-hydroxydopamine on the nigrostriatal dopaminergic pathway in rats sensitized with D-amphetamine

100%

Nowak P., Kostrzewa R. M., Kwiecinski A., Bortel A., Labus L., Brus R.

Journal of Physiology and Pharmacology

2005

tom 56

nr 2

To determine whether behavioral sensitization produced by prolonged D-amphetamine administration affects susceptibility of nigrostriatal dopaminergic neurons to the neurotoxic actions of 6-hydroxydopamine (6-OHDA), rats were treated daily from the 23 rd day after birth for 11 consecutive days with D-amphetamine (1.0 mg/kg s.c.) or saline. On the last day of treatment, one group primed with D-amphetamine and one control group of rats were tested to confirm behavioral sensitization development. The remaining animals were additionally treated on the 34 th day (one day after the last D-amphetamine injection) with 6-OHDA HBr (300 µg in 10 µl i.c.v., salt form, half in each lateral ventricle) or its vehicle. Four weeks later the levels of dopamine (DA) and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 3-metoxytyramine (3-MT), as well as 5-hydroxytrypatmine (5-HT) and its metabolite 5-hydroxyindoleacteic acid (5-HIAA) were assayed in the striatum, by HPLC/ED. In rats with behavioral sensitization, 6-OHDA reduced endogenous dopamine and its metabolites content to a comparable degree in comparison to controls. This finding indicates that presumed up-regulation of the dopamine transporter in the behaviorially sensitized rats did not increase the neurotoxicity of a high dose of 6-OHDA.

Toxicokinetic interactions of alpha-cypermethrin and chlorpyrifos in rats

67%

Wielgomas B., Krechniak J.

Polish Journal of Environmental Studies

2007

tom 16

nr 2

Preparations containing both organophosphates and pyrethroids are commonly used in insect control. Toxicokinetic interactions between α-Cypermethrin (CM ) and Chlorpyrifos (CPF) were studied in rats. The animals were given a solution of CM or CPF in rapeseed oil at a dose of 10 mg/kg and a mixture of CM and CPF at a dose of 5 mg/kg each by an intragastric tube once a day for 28 days. The concentrations of unchanged CM and CPF were determined in blood, liver and brain by GC-ECD. Also, the concentrations of CM and CPF were individually monitored in blood after administration of their single doses to calculate toxicokinetic parameters (Tmax., Cmax., AUC ). In urine the main metabolites 3-(4’-hydroxyphenoxy)benzoic acid (4OH3PBA) and 3,5,6-trichloro-2-pyridinol (TCP) were determined by HPLC in the rats treated daily with CM , CPF or their mixture. In the animals dosed with a single insecticide, the highest concentration of CM was found in blood and of CPF in liver. In the co-exposed rats, CPF decreased in all the tissues, while CM increased particularly in liver. The excretion of 4OH3PBA following CM administration increased significantly during the exposure period, whereas in the CPF-exposed rats, TCP was excreted at the same rate. Following the co-administration of both insecticides 4OH3PBA excretion decreased, but did not influence TCP excretion. In the coexposed animals, Cmax. and AUC increased for CM, and decreased for CPF.

Toxicology of pyrethroids and their relevance to human health

67%

Perger G., Szadkowski D.

Annals of Agricultural and Environmental Medicine

1994

tom 01

nr 1

Ograniczanie wyników

1 Annals of Agricultural and Environmental Medicine

1 Journal of Physiology and Pharmacology

1 Polish Journal of Environmental Studies

1 Bortel A.

1 Brus R.

1 Kostrzewa R. M.

1 Krechniak J.

1 Kwiecinski A.

1 Labus L.

1 Nowak P.

1 Perger G.

1 Szadkowski D.

1 Wielgomas B.

1 2007

1 2005

1 1994

Wyniki wyszukiwania

Neurotoxic action of 6-hydroxydopamine on the nigrostriatal dopaminergic pathway in rats sensitized with D-amphetamine

Toxicokinetic interactions of alpha-cypermethrin and chlorpyrifos in rats

Toxicology of pyrethroids and their relevance to human health