Znaleziono wyników: 3

Liczba wyników na stronie

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: neuroactive substance

Sortuj według:

Ogranicz wyniki do:

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Influence of salidroside, a neuroactive compound of Rhodiola rosea L., on alcohol tolerance development in rats

100%

Szulc M., Mularczyk P., Kujawski R., Gryszczynska A., Kaminska E., Geppert B., Baraniak J., Kania- Dobrowolska M., Ozarowski M., Krajewska-Patan A., Mikolajczak P. L.

Herba Polonica

2018

tom 64

nr 1

In recent years, the search for potential neuroprotective properties of salidroside and its ability to influence the activity of nervous system become the subject of intense studies of many research groups. None of these studies, however, include an attempt to determine the effect of salidroside on the course of alcohol tolerance in vivo. The aim of this study was to investigate the ability of salidroside to inhibit the development of alcohol tolerance in rats, determining whether the effect of its action may occur in a dose-dependent manner, reducing both metabolic and central tolerance without affecting body temperature in control rats. Male Wistar rats were injected daily with ethanol at a dose of 3 g/kg for 9 consecutive days to produce ethanol tolerance. Salidroside in two doses (4.5 mg/kg and 45 mg/kg b.w.) or vehiculum was administered orally. On the 1st, 3rd, 5th and 8th day a hypothermic effect of ethanol was measured, while the loss of righting reflex procedure was performed on the 2nd, 4th, 6th and 7th day. On the 9th day rats were treated with salidroside, sacrificed 1 h after ethanol injections and blood was collected for blood-ethanol concentration measurement. Salidroside at a dose of 45 mg/kg inhibited the development of tolerance to hypothermic and sedative effects of ethanol, whereas insignificant elevation of blood-ethanol concentration was observed. The dose of 4.5 mg/kg b.w. had minimal effect, only small inhibition of tolerance to hypothermic action was observed. Salidroside affected neither body mass growth nor body temperature in non-alcoholic (control) rats.Results of the study indicate that salidroside at a dose of 45 mg/kg inhibited the development of tolerance to the hypothermic effect of ethanol. Observed inhibition of tolerance to the sedative effect of ethanol seems to be associated with salidroside influence on the central nervous system. A comprehensive explanation of the abovementioned observations requires further pharmacological and pharmacodynamic studies.

Neuroactive substances in reproduction and development in platyhelminths

84%

Halton D. W., Maule A. G., Shaw C.

Wiadomości Parazytologiczne

1998

tom 44

nr 3

The Reproductive and Developmental Biology of Parasitic Platyhelminths. The International Satellite Symposium 10 September 1998, Olsztyn, Poland

67%

Swiderski Z.

Acta Parasitologica

1999

tom 44

nr 1

Ograniczanie wyników

1 Acta Parasitologica

1 Herba Polonica

1 Wiadomości Parazytologiczne

1 Baraniak J.

1 Geppert B.

1 Gryszczynska A.

1 Halton D. W.

1 Kaminska E.

1 Kania- Dobrowolska M.

1 Krajewska-Patan A.

1 Kujawski R.

1 Maule A. G.

1 Mikolajczak P. L.

1 Mularczyk P.

1 Ozarowski M.

1 Shaw C.

1 Swiderski Z.

1 Szulc M.

1 2018

1 1999

1 1998

Wyniki wyszukiwania

Influence of salidroside, a neuroactive compound of Rhodiola rosea L., on alcohol tolerance development in rats

Neuroactive substances in reproduction and development in platyhelminths

The Reproductive and Developmental Biology of Parasitic Platyhelminths. The International Satellite Symposium 10 September 1998, Olsztyn, Poland