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1

Copper content in neoplastic and healthy mammary glands in dogs

100%
Skibniewska E. M., Kosla T., Skibniewski M.
Bulletin of the Veterinary Institute in Puławy
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2010
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tom 54
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nr 2
269-272
The aim of the investigation was to confirm the hypothesis put forward in human research that copper is cumulated in the neoplastic tumours of the mammary gland. The research material included the post mortem collected healthy mammary glands of bitches and mammary gland neoplastic tumours obtained during routine surgical treatments. The histopathological examinations revealed that among tumours of epithelial origin, the most frequent were adenocarcinomas, which comprised 64% of all neoplastic lesions. The second group included carcinomas - 26%, whereas 10% were the tumours of mesenchymal origin. The lowest copper content was observed in healthy mammary glands. In the tissues with neoplastic lesions, the content of copper was at a much higher level. Statistical analysis revealed a significant difference (P≤0.05) in the copper content between the investigated groups. The performed analyses showed that mammary gland neoplasms cumulate copper ions, and a much higher concentration of this element is observed in the tumours of epithelial origin.
2

Transcriptomic signature of cell lines isolated from canine mammary adenocarcinoma metastases to lungs

100%
Krol M., Polanska J., Pawlowski K. M., Turowski P., Skierski J., Majewska A., Ugorski M., Morty R. E., Motyl T.
Journal of Applied Genetics
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2010
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tom 51
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nr 1
37-50
Metastasis is a final step in the progression of mammary gland cancer, usually leading to death. Potentially, a molecular signature of metastasis can be defined via comparison of primary tumors with their metastases. Currently, there is no data in the literature regarding the molecular portrait of metastases in dogs and only few reports regarding human cancer. This is the first report describing the transcriptomic signature of canine cancer metastatic cells. Two adenocarcinoma cell lines isolated from the canine mammary gland (CMT-W1 and CMT-W2) were compared with cell lines isolated from their lung metastases (CMT-W1M and CMT-W2M) with regards to the following cytometric parameters: cell cycle, ploidy, Bcl-2 expression, susceptibility to induced apoptosis, and transcriptomic profile. Cytometric analyses revealed significant differences in cell cycle and antiapoptotic potential between the examined cells. Using oligonucleotide microarrays, we found 104 up-regulated genes in the metastatic cell line CMT - W1M and 21 up-regulated genes in the primary CMT -W1 cell line. We also found 83 up-regulated genes in the CMT-W2M cell line and only 21 up-regulated genes in the CMT-W2 cell line. Among the up-regulated genes in both metastatic cell lines, we found 15 common genes. These differently expressed genes are involved mainly in signal transduction, cell structure and motility, nucleic acid metabolism, developmental processing, and apoptosis (GHSR, RASSF1, ARF1GAP, WDR74, SMOC2, SFRP4, DIAPH1, FSCN1, ALX4, SNX15, PLD2, WNT7B, POU6F2, NKG7, and POLR2F). Seven of them are involved in a cellular pathway dependent on ghrelin via growth hormone secretagogue receptor (GHSR). Our results suggest that this pathway may be essential for mammary cancer cells to have a metastatic potential.
3

Manifestation of tumours in domestic animals in Lower Silesia in 2005-2008

100%
Nowak M., Madej J. A., Ciaputa R., Poradowski D.
Bulletin of the Veterinary Institute in Puławy
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2010
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tom 54
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nr 2
229-236
The aim of this research was to analyse the frequency of prevalence and localisation of neoplasms in domestic animals. The material consisted of 1,958 tumours, originating from the area of Lower Silesia, and affecting dogs, cats, horses, cattle, and exotic animals, sampled during the surgery, autopsy or biopsy, and submitted for histopathological diagnosis. Tumours of dogs were the most frequent - 1,700 cases (87%), followed by tumours of cats - 207 cases (10.6%), horses - 20 cases (1%), cattle - 3 cases (0.2%), and exotic animals - 20 cases (1.2%) including mostly tumours of ferrets - 8 cases (0.4%). In relation to similar studies carried out in the same area during 1957-1995 and 2000-2004, an increase in neoplasms in domestic animals was observed. Skin and subcutaneous tissue neoplasms and mammary gland neoplasms (principally adenocarcinomas) dominated.
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