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Wykorzystanie nanokompozytów polimerowych zawierających nanocząstki metali jako materiałów opakowaniowych

100%

Cierpiszewski R.

Nauki Inżynierskie i Technologie

2021

nr 1(37)

Wpływ nanocząstek metali szlachetnych na układ immunologiczny zwierząt

63%

Malaczewska J.

Medycyna Weterynaryjna

2014

tom 70

nr 04

Noble metal nanoparticles, especially silver due to its antimicrobial properties, are amongst the most widely used types of nanomaterials, and so the possibility of an organism’s exposure to them is relatively high. Excluding injections, there are three natural routes they can accidentally enter the body – the skin, lungs and the alimentary tract. Research on rodents indicate that after inhalation, injection or oral administration silver, gold and copper nanoparticles can easily enter the systemic circulation and reach the internal organs. Particularly vulnerable to the harmful effects of nanoparticles are organs with an extended reticuloendothelial system, such as the spleen, where the accumulation of nanoparticles occurs. It is well proved that metallic nanoparticles are easily absorbed by macrophages located in lymphoid tissues but cannot be destroyed inside the cells. They remain unchanged in phagosomes and chronically stimulate the cells to pro-inflammatory cytokine production. They can also interact with other cell types present in the local environment, e.g. lymphocytes, which can lead to an inadequate immunological response of the organism. Many authors have described the pro-inflammatory effect of noble metal nanoparticles, both local to the application site and generalized. What is more, silver nanoparticles were able to disturb the Th1/Th2 balance or even cause an allergic response of the organism. The beneficial impact of silver nanoparticles on the immune response occurs only when they were applied externally in the form of dressings or ointments in the treatment of wounded or inflamed skin. In such cases nanosilver exhibited immunoregulatory properties accelerating the healing. An explanation for this mode of action may be the fact of relatively poor skin penetration by nanoparticles, limiting their effect to the local tissues only.

Nanocząstki - molekuły sygnalne i transporterowe w badaniach biologicznych

51%

Sawosz Chwalibog E., Grodzik M., Wierzbicki M., Hotowy A., Kutwin M., Jaworski S., Strojny B., Kurantowicz N.

Przegląd Hodowlany

2014

tom 82

nr 3

The objective of the study was to investigate the use of nanoparticles of metals and nanostructures of carbon allotropes as therapeutic and health-promoting agents. It was demonstrated that nanoparticles of silver, copper and platinum, as well as graphene nanoflakes, are toxic to Salmonella enteritldis and Listeria monocytogenes bacteria, among other microorganisms. In experiments with chicken embryos treated in ovo with molecules of silver, gold and diamond nanoparticles with attached amino acids and glycosaminoglycans, enhanced muscle growth and improved morphological structure were observed. Further experiments carried out with glioblastoma cancer cells cultured in ovo demonstrated that nanodiamond had antiangiogenic and anticancer properties. Furthermore, graphene inhibited growth rate and increased apoptosis in glioblastoma cells and caused regression of glioblastoma multiforme. The study demonstrated unique pro-healthy properties of nanoparticles depending on their type and method of application.

Ograniczanie wyników

1 Medycyna Weterynaryjna

1 Nauki Inżynierskie i Technologie

1 Przegląd Hodowlany

1 Cierpiszewski R.

1 Grodzik M.

1 Hotowy A.

1 Jaworski S.

1 Kurantowicz N.

1 Kutwin M.

1 Malaczewska J.

1 Sawosz Chwalibog E.

1 Strojny B.

1 Wierzbicki M.

1 2021

2 2014

Wyniki wyszukiwania

Wykorzystanie nanokompozytów polimerowych zawierających nanocząstki metali jako materiałów opakowaniowych

Wpływ nanocząstek metali szlachetnych na układ immunologiczny zwierząt

Nanocząstki - molekuły sygnalne i transporterowe w badaniach biologicznych