The study was aimed on determining the clinical protective value of Lydium-KLP and Methisoprinol in the prevention of respiratory system diseases, as well as their effect on the health status of pigs in large-scale commercial breeding and on the improvement of in the effectiveness of specific immunoprophylaxis of mycoplasmal pneumonia of in swine (MPS). Piglets at the age of 7 d were divided into eight groups of 25-30 piglets each. On days 7 and 21 of life they were immunised with Respisure vaccine (group I) or administrated Lydium-KLP or Methisoprinol (groups IV and VII). In other groups, Lydium-KLP or Methisoprinol were given simultaneously (groups II and V) or 48 h before immunisation with Respisure (groups III and VI). Control piglets were administrated PBS (group C). Clinical observations as well as post-slaughter and animal husbandry analyses indicated that the simultaneous administration of Lydium-KLP or Methisoprinol with Respisure gives better results in comparison to immunisation- only with Respisure. The statistically-significant differences were found in the mean percentage of meatiness between groups receiving Methisoprinol with or 48 h before Respisure and control group, as well as in the point evaluation of lesions in the lungs between groups receiving Lydium-KLP with Respisure and Methisoprinol 48 h before Respisure and control group. The study demonstrated the beneficial effect of coupled administration of Lydium-KLP or Methisoprinol and Respisure on the improvement of health status and the productive performance of pigs, as well as on the effectiveness of specific immunoprophylaxis of MPS in large- scale commercial breeding. The most beneficial variants of coupled administration were the simultaneous application of Lydium- KLP and Respisure, and Methisoprinol application 48 h before immunisation with Respisure.
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