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During the routine dissection of a 62-year-old male cadaver, bilateral atrophy of the supra and infraspinatus muscles was observed. The suprascapular nerves, cervical spinal cord and surrounding muscles were found to be normal. We propose that, in the face of normal histology and other normal shoulder girdle muscles and normal nerves, this case represents an instance of Parsonage-Turner syndrome. To our knowledge, this is the first report of bilateral spinati atrophy in a cadaver.
Spinobulbar muscular atrophy (SBMA) is an X-linked form of motor neuron disease characterized by progressive atrophy of the muscles, dysphagia, dysarthria and mild androgen insensitivity. SBMA is caused by CAG repeat expansion in the androgen receptor gene. CAG repeat polymorphism was analysed in a Polish control group (n = 150) and patients suspected of SBMA (n = 60). Normal and abnormal ranges of CAG repeats were established in the control group and in 21 patients whose clinical diagnosis of SBMA was molecularly confirmed. The ranges are similar to those reported for other populations.
This paper describes clinical and pathomorphological features of myasthenia gravis in a 7-year-old male German Shepherd dog. At clinical examination, many neurological deficits as well as swallowing and urinating problems were detected. Radiological examination revealed megaoesophagus and the ELISA test showed an elevated serum acetylcholine receptor (AChR) antibody titer. No improvement was observed after the administration of edrophonium hydrochloride. The diagnosis of myasthenia gravis was confirmed by electromyography. Despite the administration of pyridostygmine bromide, dexamethasone and antibiotics, no improvement followed, and the dog died. Necropsy was conducted: histopathological changes in the esophagus, cranial tibial muscle and lungs were described as muscular atrophy, muscular fibrosis and aspiration pneumonia. The dog’s littermate was examined and showed an elevated AChR antibody titer too, but was asymptomatic.
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