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1

Modulation of the biophysical properties of the nicotinic acetylcholine receptor channel

100%
Ruzzier F.
Biophysics of Membrane Transport
|
1992
|
tom 11
|
nr 2
2
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Immunohistochemical properties of motoneurons supplying the trapezius muscle in the rat

86%
Dudek A., Sienkiewicz W., Marczak M., Kaleczyc J.
Polish Journal of Veterinary Sciences
|
2011
|
tom 14
|
nr 2
Combined retrograde tracing (using fluorescent tracer Fast blue) and double-labelling immunofluorescence were used to study the distribution and immunohistochemical characteristics of neurons projecting to the trapezius muscle in mature male rats (n=9). As revealed by retrograde tracing, Fast blue-positive (FB+) neurons were located within the ambiguous nucleus and accessory nucleus of the grey matter of the spinal cord. Immunohistochemistry revealed that nearly all the neurons were cholinergic in nature [choline acetyltransferase (ChAT)-positive]. Retrogradely labelled neurons displayed also immunoreactivities to calcitonin gene-related peptide (CGRP; approximately 60% of FB+ neurons), nitric oxide synthase (NOS; 50%), substance P (SP; 35%), Leu5-Enkephalin (LEnk; 10%) and vasoactive intestinal polypeptide (VIP; 5%). The analysis of double-stained tissue sections revealed that all CGRP-, VIP- and LEnk-immunoreactive FB+ perikarya were simultaneously ChAT-positive. The vast majority of the neurons expressing SP- or NOS-immunoreactivity were also cholinergic in nature; however, solitary somata were ChAT-negative. FB+ perikarya were surrounded by numerous varicose nerve fibres (often forming basket-like structures) immunoreactive to LEnk or SP. They were also associated with some CGRP-, NOS- and neuropeptide Y-positive nerve terminals.
3
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Mechanisms underlying the regulation of motor unit contraction in the skeletal muscle

86%
Celichowski J.
Journal of Physiology and Pharmacology
|
2000
|
tom 51
|
nr 1
4

Variety of muscle responses to tactile stimuli

86%
Czarkowska-Bauch J.
Acta Neurobiologiae Experimentalis
|
1996
|
tom 56
|
nr 1
5
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Relationship between the tension-time area and the frequency of stimulation in motor units of the rat medial gastrocnemius muscle

86%
Celichowski J., Grottel K., Bichler E.
Journal of Physiology and Pharmacology
|
2000
|
tom 51
|
nr 2
6

Age related changes in the motoneurons of the spinal cord of the rat

86%
Karmanska W., Mikusek J., Karmanski A.
Folia Morphologica
|
1996
|
tom 55
|
nr 4
7
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

The influence of increasing and decreasing frequency of stimulation on the contraction of motor units in rat medial gastrocnemius muscle

86%
Celichowski J., Bichler E.
Journal of Physiology and Pharmacology
|
2000
|
tom 51
|
nr 4,2
8
Content available remote

Force generated by fast motor units of the rat medial gastrocnemius muscle during stimulation with pulses at variable intervals

72%
Krutki P., Pogrzebna M., Drzymala H., Raikova R., Celichowski J.
Journal of Physiology and Pharmacology
|
2008
|
tom 59
|
nr 1
During natural contractions of a muscle, motor units (MUs) are activated by irregular discharge patterns of motoneurones. The aim of this study was to analyze changes in contractile forces of MUs following patterns of stimulation at variable frequency. Experiments were performed on 33 functionally isolated MUs of the fast-type in the medial gastrocnemius (MG) muscle of adult Wistar rats, under pentobarbital anaesthesia. The MUs forces evoked at five different regular stimulation patterns of constant frequencies were compared to forces generated during five random patterns of irregular stimulation with the same mean values of interpulse intervals, between 10 and 75 ms, and variability of these intervals of ± 50% in each case. These values cover the natural range of the preferred firing rates of the MG motoneurones from unfused to nearly fused tetanic contractions. Analysis of changes in tetanic forces indicated a linear relationship between the interpulse interval as well as the initial level of the force and the amplitude of the force increase of the next contraction. It was demonstrated that variability of the instantaneous tetanic force during the irregular discharge pattern depends on the level of tetanic fusion. Moreover, it was demonstrated that for low and moderately-fused tetani, effectiveness of a MU contraction (expressed as the force-time area) is considerably higher for contractions evoked by irregular stimulation patterns. On the basis of the results of this study it was supposed that during voluntary contractions, the influence of changes in the motoneuronal firing rate on the motor unit force depends on the initial level of force.
9

Confocal visualization of the effect of short-term locomotor exercise on BDNF and TrkB distribution in the lumbar spinal cord of the rat: The enhancement of BDNF in dendrites?

72%
Macias M., Dwornik A., Skup M., Czarkowska-Bauch J.
Acta Neurobiologiae Experimentalis
|
2005
|
tom 65
|
nr 2
10

Functional reorganization of the partially denervated hindlimb extensor and flexor muscle in rat

72%
Slawinska U., Tyc F., Kasicki S., Vrbova G.
Acta Neurobiologiae Experimentalis
|
1996
|
tom 56
|
nr 1
11

Activation of the heat shock response in a primary cellular model of motoneuron neurodegeneration - evidence for neuroprotective and neurotoxic effects

58%
Kalmar B., Greensmith L.
Cellular and Molecular Biology Letters
|
2009
|
tom 14
|
nr 2
Pharmacological up-regulation of heat shock proteins (hsps) rescues motoneurons from cell death in a mouse model of amyotrophic lateral sclerosis. However, the relationship between increased hsp expression and neuronal survival is not straightforward. Here we examined the effects of two pharmacological agents that induce the heat shock response via activation of HSF-1, on stressed primary motoneurons in culture. Although both arimoclomol and celastrol induced the expression of Hsp70, their effects on primary motoneurons in culture were significantly different. Whereas arimoclomol had survival-promoting effects, rescuing motoneurons from staurosporin and H2O2 induced apoptosis, celastrol not only failed to protect stressed motoneurons from apoptosis under same experimental conditions, but was neurotoxic and induced neuronal death. Immunostaining of celastrol-treated cultures for hsp70 and activated caspase-3 revealed that celastrol treatment activates both the heat shock response and the apoptotic cell death cascade. These results indicate that not all agents that activate the heat shock response will necessarily be neuroprotective.
12

Lamina IV-VI neurones of the second sacral segment projecting to the sixth cervical segment of the cat's spinal cord

58%
Mrowczynski W.
Acta Neurobiologiae Experimentalis
|
1997
|
tom 57
|
nr 3
13

MU firing characteristics in human dystrophic muscle

58%
Piotrkiewicz M., Filipiuk M., Hausmanowa-Petrusewicz I.
Acta Neurobiologiae Experimentalis
|
1993
|
tom 53
|
nr 1
14

The volitional nature of the simplest reflex

58%
Wolpaw J. R., Carp J. S.
Acta Neurobiologiae Experimentalis
|
1993
|
tom 53
|
nr 1
15

Excitatory amino acids: physiological and pharmacological probes for neuroscience research

51%
Shinozaki H., Ishida M.
Acta Neurobiologiae Experimentalis
|
1993
|
tom 53
|
nr 1
16

Horseradish peroxidase localization of the mylohyoid motoneurones in the rabbit

51%
Gromysz H., Karczewski W. A., Kosmal A., Kukwa A.
Acta Neurobiologiae Experimentalis
|
1993
|
tom 53
|
nr 2
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