Hyphae growing for 1 h in the presence of 0.05% and 0.1% N,N-bis(3-aminopropylo)dodecyloamine (APDA) showed malformations in the nuclear structure, including changes in shape, budding, progressive disappearance of the nucleolus and chromatin, and damage of the nuclear envelope. The Allium test revealed that at both concentrations used (0.005%, 0.01%) the tested substance lowered the frequency of dividing cells and induced mitotic abnormalities such as c-metaphases, anaphase-telophase bridges and sticky chromosomes, lagging chromosomes, micronuclei, binucleate cells, budding nuclei and partial extrusion of the nucleolus from the nucleus. These data indicate that APDA has cytotoxic, mitodepressive and turbogenic effects, especially at the higher dose. The results showed that APDA may be safely used as a microbicidal agent to destroy microorganisms developing on experimental material.
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