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Family-based association analysis of the MAPT gene in Parkinson disease

100%

Wang K. S., Mullersman J. E., Liu X. F.

Journal of Applied Genetics

2010

tom 51

nr 4

The MAPT gene has been shown to be associated with several neurodegenerative disorders, including forms of parkinsonism and Parkinson disease (PD), but the results reveal population differences. We investigated the association of 10 single-nucleotide polymorphisms (SNPs) in the region of MAPT on chromosome 17q21 with PD and age at onset, by using 443 discordant sib pairs in PD from a public dataset (Mayo-Perlegen LEAPS Collaboration). Association with PD was assessed by the FBAT using generalized estimating equations (FBAT-GEE), while the association with age at onset as a quantitative trait was evaluated using the FBAT-logrank statistic. Five SNPs were significantly associated with PD (P < 0.05) in an additive model, and 9 SNPs were associated with PD (P < 0.05) in dominant and recessive models. Interestingly, 8 PD-associated SNPs were also associated with age at onset of PD (P < 0.05) in dominant and recessive models. The SNP most significantly associated with PD and age at onset was rs 17649641 (P = 0.015 and 0.021, respectively). Two-SNP haplotypes inferred from rs 17563965 and rs 17649641 also showed association with PD (P = 0.018) and age at onset (P = 0.026). These results provide further support for the role of MAPT in development of PD.

The presence of tau protein in blood as a potential prognostic factor in stroke patients

100%

Lasek-Bal A., Jedrzejowska-Szypulka H., Rozycka J., Bal W., Kowalczyk A., Holecki M., Dulawa J., Lewin-Kowalik J.

Journal of Physiology and Pharmacology

2016

tom 67

nr 5

Tau phosphorylation and assembly

100%

Gomez-Ramos A., Smith M. A., Perry G., Avila J.

Acta Neurobiologiae Experimentalis

2004

tom 64

nr 1

Expression of mRNAs for PPT, CGRP, NF-200, and MAP-2 in cocultures of dissociated DRG neurons and skeletal muscle cells in administration of NGF or NT-3

80%

Zhang W., Li H., Xing Z., Yuan H., Kindy M. S., Li Z.

Folia Histochemica et Cytobiologica

2012

tom 50

nr 2

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Folia Histochemica et Cytobiologica

1 Journal of Applied Genetics

1 Journal of Physiology and Pharmacology

1 Avila J.

1 Bal W.

1 Dulawa J.

1 Gomez-Ramos A.

1 Holecki M.

1 Jedrzejowska-Szypulka H.

1 Kindy M. S.

1 Kowalczyk A.

1 Lasek-Bal A.

1 Lewin-Kowalik J.

1 Li H.

1 Li Z.

1 Liu X. F.

1 Mullersman J. E.

1 Perry G.

1 Rozycka J.

1 Smith M. A.

1 Wang K. S.

1 Xing Z.

1 Yuan H.

1 Zhang W.

1 2016

1 2012

1 2010

1 2004

Wyniki wyszukiwania

Family-based association analysis of the MAPT gene in Parkinson disease

The presence of tau protein in blood as a potential prognostic factor in stroke patients

Tau phosphorylation and assembly

Expression of mRNAs for PPT, CGRP, NF-200, and MAP-2 in cocultures of dissociated DRG neurons and skeletal muscle cells in administration of NGF or NT-3