Ograniczanie wyników

Czasopisma help

  1. 6 Archivum Immunologiae et Therapiae Experimentalis

  2. 6 Cellular and Molecular Biology Letters

  3. 3 Acta Biochimica Polonica

  4. 2 Bromatologia i Chemia Toksykologiczna

  5. 1 Acta Mycologica

Więcej...
Autorzy help

  1. 2 Krajewska U.

  2. 2 Malicka-Blaszkiewicz M.

  3. 2 Otrocka M.

  4. 2 Rozalski M.

  5. 1 Bachta A.

Więcej...
Lata help

  1. 1 2021

  2. 1 2019

  3. 1 2017

  4. 1 2015

  5. 1 2010

Więcej...
Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 20

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych:  methotrexate
help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
1

Vesicles formed in pores

100%
Zawada Z. H.
Cellular and Molecular Biology Letters
|
2005
|
tom 10
|
nr Suppl.
2

High efficacy of methotrexate in patients with recurrent idiopathic acute anterior uveitis: a prospective study

86%
Bachta A., Kisiel B., Tlustochowicz M., Raczkiewicz A., Rekas M., Tlustochowicz W.
Archivum Immunologiae et Therapiae Experimentalis
|
2017
|
tom 65
|
nr 1
3

The effect of methotrexate on actin and invasiveness of hepatoma Morris 5123 cells in culture

86%
Otrocka M., Verschueren H., Malicka-Blaszkiewicz M.
Acta Biochimica Polonica
|
2001
|
tom 48
|
nr 4
Monomeric (G), total (T) and filamentous (F) actin and the state of actin polymerisa­tion (F:G) were determined and actin filaments were visualized in hepatoma Morris 5123 cells cultured in the presence of methotrexate (MTX) at various concentration. The exposure of the cells to this drug resulted in a decrease of total and polymerised actin in cytoplasm and in some changes in actin filament organization. This coincided with a decrease of the cells' ability to migrate through Matrigel coated filters and with inhibition of tumour formation after reimplantation of the methotrexate treated cells to experimental rats.
4

The use of adenosine releasing agents in the clinic: methotrexate and sulfasalasine

86%
Cronstein B.
Cellular and Molecular Biology Letters
|
1999
|
tom 04
|
nr 3
5

Molecular mechanism of resistance to antifolates, a review

86%
Banerjee D., Ercikan-Abali E., Waltham M., Schnieders B., Hochhauser D., Li W. W., Fan J., Gorlick R., Goker E., Bertino J. R.
Acta Biochimica Polonica
|
1995
|
tom 42
|
nr 4
Methotrexate (MTX) is a clinically important antifolate that has been used in combination with other chemotherapeutic agents in the treatment of malignancies including acute lymphocytic leukemia, osteosarcoma, carcinomas of the breast, head and neck, choriocarcinoma and non-Hodgkin's lymphoma. The primary target of MTX is the enzyme dihydrofolate reductase (DHFR) which catalyzes the reduction of folate and 7,8-dihydrofoIate to 5,6,7,8-tetrahydrofolate. Understanding of MTX action has revealed how cells acquire resistance to this drug. The four known mechanisms of MTX resistance are a decrease in the uptake of the drug, a decrease in the retention of the drug due to defective polyglutamylation or an increase in polyglutamate breakdown, an increase in the enzyme activity and a decrease in the binding of MTX to DHFR. The molecular basis for some of these mechanisms has been elucidated in MTX resistant cell lines; in particular the occurrence of gene amplification resulting in increased DHFR and point mutations resulting in altered DHFR with reduced affinity for MTX. Cloning of the human folylpolyglutamate synthase gene and the reduced folate transport gene have been reported recently and should facilitate the identification of the molecular basis of these resistant phenotypes. DHFR protein has been shown to regulate its synthesis by exerting an inhibitory influence on its own translation. Addition of MTX relieves this inhibition thus providing a possible molecular explanation for the rapid rise in DHFR activity noted in some cells after MTX administration. Alterations in genes involved in regulating the cell cycle such as cyclin D1 and the retinoblastoma (Rb) gene have also been shown to influence cellular response to MTX. Overexpression of cyclin D1 in HT1080, a human fibrosarcoma cell line, results in decreased MTX sensitivity. The molecular basis of this observation is under investigation. Abnormalities in the Rb gene may also have profound effects on MTX sensitivity. Rb interacts with the family of transcription factors called E2F reducing transcription of genes that contain E2F binding sites in the promoter regions e.g. DHFR. When Rb is deleted or rendered nonfunctional levels of "free" or unbound E2F are high resulting in enhanced transcription of genes such as DHFR. This results in increased DHFR protein and may lead to MTX resistance. As the knowledge regarding mechanisms of resistance increases newer approaches to circumvent such resistance or to target resistant cells can be undertaken.
6

Systemic treatment for severe atopic dermatitis

72%
Giavina-Bianchi M., Giavina-Bianchi P.
Archivum Immunologiae et Therapiae Experimentalis
|
2019
|
tom 67
|
nr 2
7

Assessment of the effect of methotrexate therapy on bone metabolism in patients with rheumatoid arthritis

72%
Swierkot J., Gruszecka K., Matuszewska A., Wiland P.
Archivum Immunologiae et Therapiae Experimentalis
|
2015
|
tom 63
|
nr 5
8
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Detection of cross-resistance between methotrexate and azoles in Candida albicans and Meyerozyma guilliermondii: an in vitro study

72%
Karuga F. F., Goralska K., Brzezianska-Lasota E.
Acta Mycologica
|
2021
|
tom 56
|
nr 1
9

Leflunomide and methotrexate inhibit T-lymphocyte proliferation by different molecular mechanisms involving purine and pyrimidine de novo synthesis

72%
Ruckemann K., Fairbanks L. D., Simmonds H. A.
Cellular and Molecular Biology Letters
|
1999
|
tom 04
|
nr 3
10

Influence of 2-chloro-2'-deoxyadenosine alone and in combination with cyclophosphamide or methotrexate on murine leukemia L1210

72%
Gora-Tybor J., Robak T., Warzocha K., Grieb P.
Archivum Immunologiae et Therapiae Experimentalis
|
1994
|
tom 42
|
nr 1
11

A competitive template RT-PCR to measure mRNA encoding for folate metabolizing enzymes, such as thimidylate synthase, in leukemia and colon cancer

72%
Peters G. J., Rots M. G., Noordhuis P., Mauritz R., Willey J. C., Demuth J. P., Van Zantwijk C. H., Pieters R., Jansen G.
Cellular and Molecular Biology Letters
|
1999
|
tom 04
|
nr 3
12

Lymphocyte phenotype studies of rheumatoid arthritis patients treated with methotrexate

72%
Lacki J. K., Mackiewicz S. H., Wiktorowicz K. E.
Archivum Immunologiae et Therapiae Experimentalis
|
1994
|
tom 42
|
nr 4
13

Treatment of autoimmune disease: time for a paradigm shift?

72%
Mor F.
Archivum Immunologiae et Therapiae Experimentalis
|
2007
|
tom 55
|
nr 1
14

The changes in actin content and polimerization during hepatoma Morris 5123 growth process. The effect of methotrexate

72%
Otrocka M., Nowak D., Malicka-Blaszkiewicz M.
Folia Histochemica et Cytobiologica. Supplement
|
1997
|
tom 35
|
nr 2
15

Combined methotrexate and coenzyme Q10 therapy in adjuvant-induced arthritis evaluated using parameters of inflammation and oxidative stress

58%
Bauerova K., Paulovicova E., Mihalova D., Drafi F., Strosova M., Mascia C., Biasi F., Rovensky J., Kucharska J., Gvozdjakova A., Ponist S.
Acta Biochimica Polonica
|
2010
|
tom 57
|
nr 3
Rheumatoid arthritis is a common severe joint disease that affects all age groups, it is thus of great importance to develop new strategies for its treatment. The aim of the present study was to examine the combined effect of coenzyme Q10 (CoQ10) and methotrexate (MTX) on the progression of adjuvant-induced arthritis in rats. Adjuvant arthritis (AA) was induced by a single intradermal injection of heat-inactivated Mycobacterium butyricum in incomplete Freund's adjuvant. The experiments included healthy animals, arthritic animals not treated, arthritic animals treated with CoQ10, with methotrexate, and with a combination of CoQ10 and methotrexate. The two latter groups received a daily oral dose of 20 mg/kg b.w. of CoQ10, either alone or with methotrexate in an oral dose of 0.3 mg/kg b.w. twice a week. We found that CoQ10 potentiated both the antiarthritic (decrease of hind paw volume) and the antioxidant effect of methotrexate on the level of oxidation of proteins (suppression of protein carbonyl level in plasma) as well as lipoperoxidation (suppression of levels of HNE-adducts and MDA-adducts to plasma proteins). The same effect was observed for plasmatic levels of CoQ9 and IL-1α, and partially also for γ-glutamyltransferase activity assessed in joints and spleen. Moreover, the combination therapy improved the functionality of peripheral blood neutrophils in AA, with a balancing effect on the immunosuppression caused by MTX monotherapy. In summary, combined administration of CoQ10 and methotrexate suppressed arthritic progression in rats more effectively than did MTX alone. This finding may help improve treatment of rheumatoid arthritis.
16

HPLC-analysis of low amounts of methotrexate and its polyglutamates in red blood cell lysates after low-dose methotrexate maintenance treatment for childhood acute lymphoblastic leukaemia

58%
Ter Riet P. G. J. H., Brouwer C., De Abreu R. A., Bokkerink J. P. M., Trijbels F. J. M.
Cellular and Molecular Biology Letters
|
1999
|
tom 04
|
nr 3
17
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Transperitoneal transport dynamics of methotrexate in vitro: tissue and diffusion barriers

58%
Czyzewska K.
Journal of Physiology and Pharmacology
|
1995
|
tom 46
|
nr 2
18

6-mercaptopurine metabolism and TPMT activity in children with all under maintenance therapy

58%
Gutsche S., Kroplin T., Bucsky P., Iven H.
Cellular and Molecular Biology Letters
|
1999
|
tom 04
|
nr 3
19

Wplyw menadionu, metotreksatu, cisplatyny i kwasu okadejowego na komorki bialaczki szpikowej HL-60 in vitro

51%
Rozalski M., Krajewska U.
Bromatologia i Chemia Toksykologiczna
|
1997
|
tom 30
|
nr 3
283-284
20

Wplyw lacznego podania menadionu i metotreksatu na aktywnosc fosfataz bialkowych jader komorkowych watrobiaka Kirkmana-Robbins u chomikow obarczonych tym nowotworem

51%
Rozalski M., Krajewska U.
Bromatologia i Chemia Toksykologiczna
|
1997
|
tom 30
|
nr 1
99-106
Podanie menadionu łącznie z małą dawką metotreksatu powodowało znaczne hamowanie rozrostu wątrobiaka Kirkmana-Robbins u chomików. Towarzyszyło temu obniżenie zawartości zredukowanego glutationu (GSH) w tkance wątrobiaka. Zastosowane leki antynowotworowe przyczyniały się do obniżenia aktywności jądrowych fosfataz białkowych wątrobiaka - enzymów odgrywających rolę w regulacji cyklu komórkowego. Spośród indywidualnych jądrowych substratów szczególnie słabo defosforyłowane były 32P-fosfoproteiny o małych masach cząsteczkowych.
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.