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The effect of nutritional status, selected sex hormones and SHBG on plasma leptin levels in young female athletes with menstrual disorders

100%

Lagowska K., Jeszka J.

Acta Scientiarum Polonorum. Technologia Alimentaria

2010

tom 09

nr 4

469-476

Background. This study was focused on investigations of secondary regulators of plasma leptin levels such as prolactin, testosterone, sex hormone binding globulin (SHBG) and nutritional status, in young female athletes with menstrual disorders. Material and methods. Thirty four female professional rowers with menstrual disorders (iamenorrhoea and oligomenorrhoea), aged 18.1 ±2.0, with a training period of 4.3 ±2.1 and BMI of 21.0 ±2.1 kg/m2, with too high (IL) or too Iow plasma leptin levels (DL) participated in the study. The nutritional status was evaluated based on the analysis of body composition using the BIA method - percentage of adipose tissue (FM) and fat free mass (FFM) and skinfold thickness (ST) using a Harpenden skinfold caliper. Moreover, serum levels of leptin, prolactin, testosterone and SHBG were estimated using RIA kits. Results. Values of BMI, ST, FM were significantly (p < 0.05) higher in IL athletes, while FFM was significantly (p < 0.05) lower compared to DL rowers (BMI: IL 22.3 ±2.2 kg/m2, DL 20.2 ±1.4 kg/m2, ST: IL 12.4 ±4.0 mm, DL 9.5 ±2.1 mm, FM: IL: 23.2 ±4.9%, DL: 19.3 ±3.3%, FFM: IL 76.8 ±4.9%, DL 80.7 ±3.4%). The results of plasma leptin level correlated (p < 0.05) with anthropometric parameters (age: r = -0.38, body mass: r = 0.46, BMI: r = 0.59, ST: r = 0.40), body composition (FM%: r = 0.48, FM kg: r = 0.55, FFM%: r = -0.48), prolactin (r = 0.72) and testosterone levels (r = 0.43). Conclusions. The results confirmed the strong influence of body mass and fat mass on serum leptin levels. However, high prolactin and testosterone levels may also favourably increased plasma leptin levels in athletes and also affect menstrual disorders.

A postgenomic integrated view of prostaglandins in reproduction: implications for other body systems

80%

Fortier M. A., Krishnaswamy K., Danyod G., Boucher-Kovalik S., Chapdelaine J. A.

Journal of Physiology and Pharmacology. Supplement

2008

tom 59

nr 1

Prostaglandins are primary mediators of pain and are involved in pathological conditions such as hypertension, cancer and inflammation but are also needed for normal function of the female reproductive system. This may hold true for other systems because long term use of selective COX-2 inhibitors such as VIOXX and BEXTRA was associated with heart failure, leading to their withdrawal. A thorough study of the contribution of prostaglandins in the regulation of normal body function is clearly needed. A major drawback of the current therapeutic strategies aiming at controlling PGs is that they aim at early steps of biosynthesis thus blocking all PGs, good and bad. However, PGs often work as opposing dyads such as PGI2-TXA2 in the vascular system and PGF2-PGE2 in the female reproductive system. The paradigm thus appears as effecting selective synthesis, transport and action of individual PG isoforms. In this respect, the female reproductive system appears as an ideal study model. Data from human and animal genome projects allowed identifying the corresponding members of the biosynthetic and signal transduction components of the PG system in different animal species. Of particular interest was that PG terminal synthase shared similarities or identity with enzymes previously known for steroid or sugar metabolism and free radical detoxification. We present here an integrated view of PG action based on observations in the female reproductive system, but with potential strategic implications for cardiovascular and metabolic complications.

Ograniczanie wyników

1 Acta Scientiarum Polonorum. Technologia Alimentaria

1 Journal of Physiology and Pharmacology. Supplement

1 Boucher-Kovalik S.

1 Chapdelaine J. A.

1 Danyod G.

1 Fortier M. A.

1 Jeszka J.

1 Krishnaswamy K.

1 Lagowska K.

1 2010

1 2008

Wyniki wyszukiwania

The effect of nutritional status, selected sex hormones and SHBG on plasma leptin levels in young female athletes with menstrual disorders

A postgenomic integrated view of prostaglandins in reproduction: implications for other body systems