Wyniki wyszukiwania

1

Membrane receptors for steroid hormones?

100%

Marcinkowska E.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

2

Localization of kappa opioid receptor in porcine granulosa cells

86%

Slomczynska M., Gregoraszczuk E.

Folia Histochemica et Cytobiologica. Supplement

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1997

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tom 35

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nr 2

3

Influence of iron depletion on growth kinetics, siderophore synthesis and iron-regulated proteins expression in staphylococci

86%

Lisiecki P., Sobis-Glinkowska M., Wysocki P., Szarapinska-Kwaszewska J., Mikucki J.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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2001

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tom 49

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nr 1

4

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Sensitivity analysis of mathematical models of signalling pathways

72%

Charzynska A., Nalecz A., Rybinski M., Gambin A.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2012

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tom 93

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nr 3

5

Characterisation of integrin content in human normal aortic valves and in valves affected by calcific aortic stenosis

72%

Przybylo M., Stepien E., Pfitzner R., Litynska A., Sadowski J.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr 3

6

Talin distribution during differentiation of satellite cells isolated from m.EDL and m.Soleus treated by phorbol ester

72%

Brzoska E., Wrobel E., Moraczewski J.

Cellular and Molecular Biology Letters

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2001

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tom 06

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nr 2

7

Studies on nongenomic action by steroid hormones

72%

Kotwicka M., Filipiak K., Butowska W., Warchol J. B.

Acta Biologica Cracoviensia. Series Botanica et Zoologia. Supplement

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1997

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tom 39

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nr 1

8

FGF binding by extracellular matrix components of Wharton's jelly

72%

Malkowski A., Sobolewski K., Jaworski S., Bankowski E.

Acta Biochimica Polonica

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2007

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tom 54

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nr 2

Our earlier paper has reported that Wharton's jelly is a reservoir of several peptide growth factors, including acidic and basic fibroblast growth factors (aFGF and bFGF, respectively). Both can be extracted by buffered salts solutions in the form of high molecular mass complexes, probably with a component(s) of the extracellular matrix. Both aFGF and bFGF from such extracts hardly penetrate 10% polyacrylamide gels during electrophoresis. Pre-treatment of Wharton's jelly with hyaluronidase slightly increased the extractability of aFGF, but did not affect the extractability of bFGF. In contrast, the pre-treatment of tissue homogenate with bacterial collagenase (2000 U/ml, 37°C, 18 h) increased the extractability of bFGF. The presence of β-mercaptoethanol in the extracting solutions increased the extractability of both FGFs, but did not release FGFs in their free form, despite reducing the molecular mass of the FGF-containing complexes. We conclude that both aFGF and bFGF are bound through disulphide bonds to a protein component of Wharton's jelly. We propose that ground substance composed mainly of collagen fibrils and hyaluronate molecules, which surrounds the cells of Wharton's jelly, prevents the access of the extracting solution to aFGF and bFGF. Although hyaluronate and collagen do not bind aFGF or bFGF directly, they may constitute a barrier which prevents the dispersion of FGFs in Wharton's jelly. Thus, the high concentration of FGFs around the cells of Wharton's jelly may facilitate the interaction of these factors with membrane receptors, thereby resulting in stimulation of cell division and differentiation, as well as of the synthesis of extracellular matrix components.

9

Steroid signal transduction activated at the cell membrane: from plants to animals

58%

Marcinkowska E., Wiedlocha A.

Acta Biochimica Polonica

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2002

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tom 49

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nr 3

Steroid hormones in plants and in animals are very important for physiological and developmental regulation. In animals steroid hormones are recognized by nuclear receptors, which transcriptionally regulate specific target genes following binding of the ligand. In addition, numerous rapid effects generated by steroids appear to be mediated by a mechanism not depending on the activation of nuclear receptors. Although the existence of separate membrane receptors was postulated many years ago and hundreds of reports supporting this hypothesis have been published, no animal membrane steroid receptor has been cloned to date. Meanwhile, a plant steroid receptor from Arabidopsis thaliana has been identified and cloned. It is a transmembrane protein which specifically recognizes plant steroids (brassinosteroids) at the cell surface and has a serine/threonine protein kinase activity. It seems that plants have no intracellular steroid receptors, since there are no genes homologous to the family of animal nuclear steroid receptors in the genome of A. thaliana. Since the reason of the rapid responses to steroid hormones in animal cells still remains obscure we show in this article two possible explanations of this phenomenon. Using 1,25-dihydroxyvitamin D3 as an example of animal steroid hormone, we review results of our and of other groups concordant with the hypothesis of membrane steroid receptors. We also review the results of experiments performed with ovarian hormones, that led their authors to the hypothesis explaining rapid steroid actions without distinct membrane steroid receptors. Finally, examples of polypeptide growth factor that similarly to steroids exhibit a dual mode of action, activating not only cell surface receptors, but also intracellular targets, are discussed.

Ograniczanie wyników

Membrane receptors for steroid hormones?

Localization of kappa opioid receptor in porcine granulosa cells

Influence of iron depletion on growth kinetics, siderophore synthesis and iron-regulated proteins expression in staphylococci

Sensitivity analysis of mathematical models of signalling pathways

Characterisation of integrin content in human normal aortic valves and in valves affected by calcific aortic stenosis

Talin distribution during differentiation of satellite cells isolated from m.EDL and m.Soleus treated by phorbol ester

Studies on nongenomic action by steroid hormones

FGF binding by extracellular matrix components of Wharton's jelly

Steroid signal transduction activated at the cell membrane: from plants to animals