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Antibacterial study of the medium chain fatty acids and their 1-monoglycerides: individual effects and synergistic relationships

100%
Batovska D. I., Todorova I. T., Tsvetkova I. V., Najdenski H. M.
Polish Journal of Microbiology
|
2009
|
tom 58
|
nr 1
43-47
The antibacterial activity of the medium chain fatty acids and their 1-monoglycerides was evaluated towards several Gram-positive strains belonging to the genera Staphylococcus, Corynebacterium, Bacillus, Listeria and Streptococcus. The 1 -monoglycerides were more active than the fatty acids with monolaurin being the most active compound. Interesting effects were observed when the streptococcal strain Streptococcus pyogenes was used as a test microorganism. First, blocking of the hydroxyl groups of the glycerol moiety of monolaurin led to a compound with remarkable antibacterial activity (MIC, 3.9 μg/ml). Secondly, synergistic relationships were observed between monolaurin and monocaprin as well as between monolaurin and the poorly active lauric acid when their two component mixtures were examined. The mixtures in which one of the components was 2-fold more predominant than the other one were much more active than the pure components taken individually. Moreover, the presence of the components in ratio 1:1 was disadvantageous. Synergistic relationships were also found between monolaurin and monomyristin towards Staphylococcus aureus 209 when monomyristin was in the same quantity as monolaurin or in shortage.
2
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Antioxidant property and GCMS profile of oil extracted from Cocos nucifera using a fermentation method

100%
Adenike A. A., Adegbola P., Fadahunsi O. S.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
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2019
|
tom 100
|
nr 4
3

Medium-chain fatty acids as feed supplements for weaned piglets

84%
Hanczakowska E., Swiatkiewicz M., Hanczakowski P., Wrobel A.
Medycyna Weterynaryjna
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2010
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tom 66
|
nr 05
331-334
The aim of this experiment was to examine the effect of medium- and short-chain fatty acids (Selacid preparation) on piglets’ health, body weight gains, changes in intestinal microflora and intestinal wall morphology. The amount of aerobic and anaerobic bacteria, yeasts and moulds, the acidity and the content of volatile fatty acids (VFA) of digesta were estimated. The effect of these acids was compared with the effect of the traditional acidifier i.e. fumaric acid. The experiment involved 183 piglets allocated to 3 experimental groups, 6 litters in each. Group I (control) was fed with the standard mixture with no supplement. Group II received the same mixture supplemented with 1.5% of fumaric acid and group III received feed mixture supplemented with 0.5% of the Selacid preparation. Experiment was completed at the 84th day of the piglets’ life. Selacid improved the piglets’ body weight gains when compared to the control group (283 and 268 g, respectively) but this difference was not significant. Body weight gains of piglets receiving fumaric acid (269 g) did not differ from the control ones (268 g). Selacid had a moderate antibacterial effect: it lowered the number of Clostridium in small intestine digesta by 33%. Fumaric acid significantly lowered the amount of Escherichia coli. Acids had no effect on yeast and mould population. Piglets receiving fumaric acid had higher intestinal villi than those receiving Selacid and the control ones (302, 257 and 233 µm, respectively) but that had no effect on their body weight gains. The content of volatile fatty acids and the acidity of intestinal digesta were also similar in all groups. It is concluded that medium-chain fatty acid contained in the Selacid preparation can improve piglets’ health and performance though this improvement is not related to changes in microflora or the structure of intestine mucosa in the scope of this research.
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