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Wplyw kurkuminy na detoksykacyjne i antyoksydacyjne mechanizmy w watrobie szczurow podczas starzenia

100%

Gutowicz M., Cholojczyk M., Pyrzanowska J., Widy-Tyszkiewicz E., Baranczyk-Kuzma A.

Medycyna Weterynaryjna

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2008

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tom 64

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nr 07

955-957

Curcumin (diferuloylmethane), a yellow poliphenol pigment isolated from rhizome of Curcuma longa, has been used throughout Asia for several thousands of years. Beside giving curry dishes their color, curcumin has been reported as an agent used in the treatment of various disorders. The aim of this study was to determine the effect of chronic curcumin administration on enzymatic and nonenzymatic protective mechanisms in the livers of aging rats. The liver was isolated from Wistar Albino Glaxo rats, age 6 and 22 months. All rats were fed a standard chow diet. Two groups of older animals were given a standard diet supplemented either with 10 mg/kg b.w. or with 50 mg/kg b.w. of curcumin powder for 10 weeks before their sacrifice. Malondialdehyde level, reduced glutathione, the activity of catalase, glutathione S-transferase, and arginase were determined. Increased lipid peroxidation was observed in old rat livers, elevated catalase and arginase activities, as well as the level of reduced glutathione in curcumin fed animals. No changes in glutathione S-transferase activity were found. It may be concluded that curcumin administered in a diet exerts an antioxidant effect and protects the liver against ammonia intoxication.

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Badania mechanizmów detoksykacyjnych insektycydów fosforoorganicznych i karbaminianowych

100%

Palut D.

Roczniki Państwowego Zakładu Higieny

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1973

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tom 24

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nr 6

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Wpływ wieku i suplementacji kurkuminą na skuteczność mechanizmów detoksykacyjnych w tkankach szczura

80%

Gutowicz M., Augustyn A., Pyrzanowska J., Widy-Tyszkiewicz E., Baranczyk-Kuzma A.

Medycyna Weterynaryjna

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2011

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tom 67

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nr 01

Curcumin is a yellow pigment extracted from the rhizome of Curcuma Longa. It has been used in Asia for several thousand years as a spice, antibacterial, anti-inflammatory and digestive agent. Current research reports that curcumin exhibits antioxidative, anticancer and neuroprotective properties. The aim of this study was to compare the activity of catalase (CAT), glutathione S-transferase (GST) and arginase (ARG) in the rat kidney, heart and skeletal muscle during aging, as well as to determine the effect of systematic curcumin supplementation on the activity of the above enzymes in old animals. Studies were conducted on adult (6 months of age) and old (22 months of age) Wistar Albino Glaxo males. The animals were separated into four groups of 7-8 rats each. Groups I and II were given a standard diet without curcumin, groups III and IV were on a diet supplemented with 10 and 50 mg/kg b.w. of curcumin, respectively. Ageing was observed to have no effect on CAT activity in any of the tissues under investigation, whereas GST activity decreased in both the kidney and the skeletal muscle but not in the heart. In the kidney the level of GSH significantly decreased, but ARG activity increased. After the administration of curcumin to old rats, the activities of CAT and GST increased in the kidney and the skeletal muscle, but not in the heart. The level of GSH was higher in the kidney, but ARG activity remained unchanged. Thus, curcumin supplementation has a positive effect on detoxification processes in extrahepatic tissues of old rats.

Ograniczanie wyników

2 Medycyna Weterynaryjna

1 Roczniki Państwowego Zakładu Higieny

2 Baranczyk-Kuzma A.

2 Gutowicz M.

2 Pyrzanowska J.

2 Widy-Tyszkiewicz E.

1 Augustyn A.

1 Cholojczyk M.

1 Palut D.

1 2011

1 2008

1 1973

Wplyw kurkuminy na detoksykacyjne i antyoksydacyjne mechanizmy w watrobie szczurow podczas starzenia

Badania mechanizmów detoksykacyjnych insektycydów fosforoorganicznych i karbaminianowych

Wpływ wieku i suplementacji kurkuminą na skuteczność mechanizmów detoksykacyjnych w tkankach szczura