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1

The role of immunohistochemical examination in diagnosis of papillary thyroid cancer in struma ovarii

100%
Szczepanek-Parulska E., Pioch E., Cyranska-Chyrek E., Wolinski K., Jarmolowska-Jurczyszyn D., Janicka-Jedynska M., Majewski P., Zabel M., Ruchala M.
Folia Histochemica et Cytobiologica
|
2019
|
tom 57
|
nr 1
2

Lobular neoplasia found on breast biopsy: marker of increased risk of malignancy or direct pre-cancerous lesion?

84%
Szynglarewicz B., Matkowski R., Halon A., Kasprzak P., Forgacz J., Gisterek I., Kornafel J.
Folia Histochemica et Cytobiologica
|
2011
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tom 49
|
nr 3
3
Content available remote

Stem cells as a two edged sword - from regeneration to tumor formation

84%
Kucia M., Ratajczak M. Z.
Journal of Physiology and Pharmacology. Supplement
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2006
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tom 57
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nr 7
5-16
Evidence has accumulated that quiescent stem cells or cells developmentally closely related to them distributed in various organs may be a cellular origin of cancer development. In support of this notion, stem cells (SC) are long-lived cells with distinctive properties of self-renewal and has the potential to proliferate extensively. Given these features, it’s possible that they may become the subject of consecutive accumulated mutations that are crucial for initiation of cancer. Therefore, mutations that occur in normal stem cells might lead to their malignant transformation and tumor initiation. Furthermore, many biological features of normal and cancer SC such as the physiological trafficking of normal and metastasis of cancer stem cells involve similar molecular mechanisms, and we discuss these similarities here.
4

Endometriosis — insights into a multifaceted entity

84%
Amalinei C., Pavaleanu I., Lozneanu L., Balan R., Giusca S.-E., Caruntu I.-D.
Folia Histochemica et Cytobiologica
|
2018
|
tom 56
|
nr 2
5

Cellular interactions in the intestinal stem cell niche

84%
Pastula A., Marcinkiewicz J.
Archivum Immunologiae et Therapiae Experimentalis
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2019
|
tom 67
|
nr 1
6

Interleukin-1 gene polymorphisms in chronic gastritis patients infected with Helicobacter pylori as risk factors of gastric cancer development

67%
Hnatyszyn A., Wielgus K., Kaczmarek-Rys M., Skrzypczak-Zielinska M., Szalata M., Mikolajczyk-Stecyna J., Stanczyk J., Dziuba I., Mikstacki A., Slomski R.
Archivum Immunologiae et Therapiae Experimentalis
|
2013
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tom 61
|
nr 6
7

The malignant transformation of Syrian hamster embryo [SHE] cells in primary culture by malachite green: the transformation is associated with enhanced vimentin phosphorylation, PCNA expression and BrdU incorporation

67%
Mahudawala D. M., Redkar A. A., Rao K. V. K.
Cellular and Molecular Biology Letters
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2000
|
tom 05
|
nr 1
Malachite green (MG) consisting of green crystals with a metallic lustre, is very soluble in water and is highly cytotoxic to mammalian cells and also acts as a liver tumor promoter. In view of its industrial importance and possible exposure to human beings, MG poses a potential environmental health hazard. The malignant transformation of Syrian hamster embryo (SHE) cells by MG has been reported earlier. In this study, an attempt has been made to study the levels of vimentin, vimentin phosphorylation and the expression of PCNA and BrdU incorporation in MG transformed cells compared to control cells. Immunohistochemical and immunoprecipitation studies showed enhanced levels of vimentin in transformed cells compared to normal cells. Metabolic labelling studies showed an overall increase in phosphorylation of total cellular proteins as well as hyperphosphorylation of vimentin in transformed cells. Transformed cells also showed an increased doubling time, PCNA expression and BrdU incorporation. This study indicates a close relationship between vimentin levels, hyperphosphorylation of vimentin and increased cell proliferation associated with the malignant transformation of SHE cells.
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