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1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Towards the production of microalgae biofuels: the effect of the culture medium on lipid deposition

100%
Cuellar Garcia D. J., Rangel-Basto Y. A., Barajas-Solano A. F., Munoz-Penalosa Y. A., Urbina-Suarez N. A.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
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2019
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tom 100
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nr 3
2

Inhibition and regression of atherosclerotic lesions

100%
Oka K., Chan L.
Acta Biochimica Polonica
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2005
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tom 52
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nr 2
Atherosclerosis, once believed to be a result of a slow, irreversible process resulting from lipid accumulation in arterial walls, is now recognized as a dynamic process with reversibility. Liver-directed gene therapy for dyslipidemia aims to treat patients who are not responsive to currently available primary and secondary prevention. Moreover, gene therapy strategies have also proved valuable in studying the dynamics of atherosclerotic lesion formation, progression, and remodeling in experimental animals. Recent results on the long-term effect of gene therapy suggest that hepatic expression of therapeutic genes suppresses inflammation and has profound effects on the nature of the atherogenic process.
3

Conjugated linoleic acids regulate triacylglycerol and cholesterol concentrations in macrophages/foam cells by the modulation of CD36 expression

80%
Stachowska E., Baskiewicz M., Marchlewicz M., Czuprynska K., Kaczmarczyk M., Wiszniewska B., Machalinski B., Chlubek D.
Acta Biochimica Polonica
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2010
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tom 57
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nr 3
Atherosclerosis is an inflammatory disease characterised by the accumulation of lipids and their metabolites in the artery wall. During inflammation circulating LDL are taken up by macrophages through two major scavenger receptors: CD36 and scavenger receptor A (SRA). Fatty acids that are common in food, e.g. linoleic acid and n-3 unsaturated fatty acids can modulate expression of CD36 on the macrophage surface. Conjugated linoleic acid isomers (CLA) that originate from the human diet, have demonstrated antiatherogenic properties in several experiments. Animal study evidenced that CLA could induce resolution of plaque by activation of peroxisome proliferator activated receptors and down-regulation of pro-inflammatory genes. Less unequivocal results were obtained in human studies (on the CLA effects on the inflammatory process). Therefore in this study we investigated the influence of CLA on CD36 expression and lipid accumulation in human macrophages. Macrophages were incubated with 30 µM cis-9,trans-11 CLA, trans-10,cis-12 CLA or linoleic acid for 48 h. After that, expression of CD36 as well as accumulation of lipids were measured by flow cytometry, microscopy and a spectroscopic method. We demonstrate that both cis-9,trans-11 C 18 : 2 CLA and linoleic acid slightly elevated expression of CD36, whereas second isomer - trans-10,cis-12 CLA - did not. Nevertheless, only trans-10,cis-12 CLA triggered delipidation of macrophages, that is decreased triacylglycerols concentration. Also in human adipocytes, trans-10,cis-12 CLA causes cell delipidation by reduction of PPAR receptor expression. We propose a similar mechanism for human macrophages/foam cells.
4
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Effect of Mimosa pudica cured extract against high fructose diet induced type 2 diabetes in rats

80%
Sundaresan A., Radhiga T.
International Letters of Natural Sciences
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2015
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tom 39
The study evaluated the effects of Mimusa pudica (M. pudica) leaf extract on type 2 diabetes in rats fed high fructose diet (HFD). Rats were fed either control diet or HFD for 14 days, following which the diet was fortified with M. Pudica at a dose of 500 mg/kg BW. After 8 weeks, HFD caused deleterious metabolic effects, including increased body weight, hyperglycemia, hyperinsulinemia, dyslipidemia and liver dysfunction. Further, rats fed HFD alone showed increased activities of hepatocellular enzymes in plasma and lipid deposition in liver. Treatment with M. pudica significantly reduced the body weight, improved insulin sensitivity, managed the dyslipidemia and reduced liver damage towards normal. Histopathology of the liver confirmed the changes induced by HFD and the M. pudiac treatment significantly reversed towards normality. These data suggest that M. pudica treatment improve insulin sensitivity and attenuates fat accumulation in liver.
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