Wyniki wyszukiwania

1

Prophylactic potential of montelukast against mild colitis induced by dextran sulphate sodium in rats

100%

Holma R., Salmenpera P., Virtanen I., Vapaatalo H., Korpela R.

Journal of Physiology and Pharmacology

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2007

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tom 58

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nr 3

Cysteinyl leukotrienes play a part in inflammatory processes such as inflammatory bowel diseases. The present study aimed to evaluate the effects of the cys-LT-1 receptor antagonist montelukast on a mild colitis model in rats. Colitis was induced by administrating 4% dextran sulphate sodium (DSS, MW 45 000) in drinking water for 9 days. Montelukast (10 mg/kg/day) or vehicle was given by gastric gavage once daily simultaneously with DSS administration. A healthy control group receiving water as drinking fluid and vehicle by gastric gavage was included. Body weight loss, consistency of faeces (loose/diarrhoea) and occult blood in the faeces/ gross bleeding were assessed on days 6 - 9. After sacrifice, the following were assessed: colonic histology, the expression of inducible nitric oxide synthase, macrophage/monocyte marker ED1, cyclooxygenase-1 and cyclooxygenase-2, as well as the production of leukotriene B4 and E4, prostaglandin E2, its metabolite bicyclic-prostaglandin E2 and thromboxane B2 in the colonic tissue incubation in vitro. Rats receiving DSS exhibited bloody diarrhoea from day 6 onwards. Montelukast significantly reduced the occult blood in the faeces/ gross bleeding, maintained normal body weight gain and tended to decrease the ratio of leukotriene B4/ prostaglandin E2 production in the colon in vitro. The results indicate that montelukast has some potential to ameliorate mild experimental colitis induced by DSS.

2

Effect of serine proteinase inhibitors on intracellular free calcium rise in human polymorphonuclear leukocytes after stimulation with receptor agonists

84%

Nowak D., Krol M., Bialasiewicz P.

Archivum Immunologiae et Therapiae Experimentalis

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1998

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tom 46

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nr 2

3

The measurement of leukotrienes in urine as diagnostic option in systemic mastocytosis

67%

Raithel M., Zopf Y., Kimpel S., Naegel A., Molderings G. J., Buchwald F., Schultis H. W., Kressel J., Hahn E. G., Konturek P.

Journal of Physiology and Pharmacology

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2011

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tom 62

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nr 4

4

Leukotriene B4, 8-iso-prostaglandin F2alpha, and pH in exhaled breath condensate from asymptomatic smokers

59%

Hoffmeyer F., Harth V., Bunger J., Bruning T., Raulf-Heimsoth M.

Journal of Physiology and Pharmacology. Supplement

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2009

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tom 60

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nr 5

5

Role of nitric oxide-synthase and cyclooxygenase/lipooxygenase systems in development of experimental ulcerative colitis

59%

Sklyarov A. Y., Panasyuk N. B., Fomenko I. S.

Journal of Physiology and Pharmacology

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2011

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tom 62

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nr 1

Development of ulcerative colitis was accompanied by the activation of iNOS/COX-2/5-LOX and increased contents of nitric oxide (NO), prostaglandin E2 (PGE2), and leukotriene B4 (LTB4). The following information was assessed: morphological changes, activity of nitric oxide-synthase, content of nitric oxide, and indexes of lipoperoxidation processes in the mucous membrane of the large intestine (MMLI). Colitis was induced in rats by intrarectal administration of 1 ml of 4% acetic acid. Aminoguanidine - selective inducible nitric oxide-synthase (iNOS) blocker, celecoxib – cyclooxygenase-2 (COX-2) inhibitor, indomethacin - non-selective COX inhibitor and AA-861 – 5-lipooxygenase (5-LOX) blocker were administered in 1 ml volumes per os 1 hour before and 24 hours after the intrarectal application of acetic acid. It was noticed that blockage of iNOS by aminoguanidine caused enhancement of cytoprotective mechanisms, reduction of iNOS activity and oxidative stress, and an increase in blood L-arginine level as compared to their respective indexes in colitis. Combined blockage of iNOS and COX-2 displayed additive character of their effect on the processes of lipoperoxidation and activity of iNOS. Combined blockage of iNOS, COX-2 and 5-LOX had a manifested cytoprotective effect under condition of ulcerative colitis and was accompanied by a sharp decline in NOS activity and oxidative stress. If each of these systems, iNOS/NO, COX-2/PGE2 and 5-LOX/LTB4 are simultaneously activated due to inflammation, they contribute to the destructive damage of the MMLI, development of oxidative stress, and affect components of the antioxidant protection system. The obtained results substatiate the relevance of treatment of the inflammatory processes with the use of madication capable of combined blockage of iNOS, COX-2, and 5-LOX.

Ograniczanie wyników

3 Journal of Physiology and Pharmacology

1 Archivum Immunologiae et Therapiae Experimentalis

1 Journal of Physiology and Pharmacology. Supplement

1 Bialasiewicz P.

1 Bruning T.

1 Buchwald F.

1 Bunger J.

1 Fomenko I. S.

1 Hahn E. G.

1 Harth V.

1 Hoffmeyer F.

1 Holma R.

1 Kimpel S.

1 Konturek P.

1 Korpela R.

1 Kressel J.

1 Krol M.

1 Molderings G. J.

1 Naegel A.

1 Nowak D.

1 Panasyuk N. B.

1 Raithel M.

1 Raulf-Heimsoth M.

1 Salmenpera P.

1 Schultis H. W.

1 Sklyarov A. Y.

1 Vapaatalo H.

1 Virtanen I.

1 Zopf Y.

2 2011

1 2009

1 2007

1 1998

Prophylactic potential of montelukast against mild colitis induced by dextran sulphate sodium in rats

Effect of serine proteinase inhibitors on intracellular free calcium rise in human polymorphonuclear leukocytes after stimulation with receptor agonists

The measurement of leukotrienes in urine as diagnostic option in systemic mastocytosis

Leukotriene B4, 8-iso-prostaglandin F2alpha, and pH in exhaled breath condensate from asymptomatic smokers

Role of nitric oxide-synthase and cyclooxygenase/lipooxygenase systems in development of experimental ulcerative colitis