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Impact of LEP and LEPR gene polymorphisms on functional traits in Polish Holstein-Friesian cattle

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Komisarek J.

Animal Science Papers and Reports

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2010

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tom 28

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nr 2

Five single nucleotide polymorphisms in leptin and leptin receptor genes were analysed for their possible impact on estimating breeding values for somatic cell count score (SCS) in milk, longevity and reproductive traits. Used were 309 active Polish Holstein-Friesian bulls. The LEP-C(-963)T,LEP-Y7F, LEP-R25C, LEP-A80V, and LEPR-T945M genotypes were identified using the PCRRFLP method. For linked leptin mutations, the additional haplotype analysis was performed. The results obtained suggest that three polymorphisms of bovine LEP gene may be associated with nonreturn rate in cows. The most significant effect was found for LEP-A80V. Moreover, the LEPRT945M mutation seemed to be related to the age at first insemination.

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The relationship between the T945M single nucleotide polymorphism in the leptin receptor gene (LEPR) and milk production traits in Jersey cows

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Komisarek J., Dorynek Z.

Animal Science Papers and Reports

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2006

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tom 24

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nr 4

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Searching for genes controlling fatness traits in pigs - a review

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Switonski M., Chmurzynska A., Mackowski M.

Animal Science Papers and Reports

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2003

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tom 21

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nr 2

Fat content of carcass is an important multigenic trait in pig breeding. There are reports indicating several chromosomes, e.g. 1, 2, 4, 5, 6, 7, 12, 13, 14 and 18 which possibly harbour QTLs for fatness traits. Among QTL candidate genes there are leptin (LEP) and its receptor (Lepr), both playing essential role in food intake and energy balance. Moreover, expression level and polymorphism of the adipocyte specific transcription factors, such as CREB (cAMP response element binding protein) or C/EBP (CCAAT/enhancer-binding protein) may also cause phenotypic variation of the fatness traits. Some of the candidate QTLs, as Lep, Lepr, C/EBP and additionally H-FABP (fatty acid binding protein gene) and RYR1, are localized on chromosome 6. It is foreseen that searching for polymorphisms of the chosen genes may reveal association between a genotype and phenotypic variation of selected fatness traits. However, the studies are complex and require analysis of numerous genes.Cited are 71 references.

Ograniczanie wyników

3 Animal Science Papers and Reports

2 Komisarek J.

1 Chmurzynska A.

1 Dorynek Z.

1 Mackowski M.

1 Switonski M.

1 2010

1 2006

1 2003

Impact of LEP and LEPR gene polymorphisms on functional traits in Polish Holstein-Friesian cattle

The relationship between the T945M single nucleotide polymorphism in the leptin receptor gene (LEPR) and milk production traits in Jersey cows

Searching for genes controlling fatness traits in pigs - a review