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Immunosuppression during Leishmania donovani infection: a potential target for the development of therapy

100%

Flora R., Aghazadeh-Dibavar S., Bandyopadhyay M., Dasgupta S.

Annals of Parasitology

2014

tom 60

nr 4

Dysfunction of T-helper 1 mediated immune responses is a hallmark of the progression of visceral leishmaniosis (VL). Several factors such as altered antigen presentation, and abnormalities in MHC/HLA, antigen processing, and T cell receptor recognition regulate the onset of immunosuppression. Recent investigations on VL patients suggest that susceptibility to visceral leishmaniosis is genetically determined and varies between populations in different geographical locations. Emerging evidence also indicates the importance of the role played by myeloid derived suppressor cells in progressive VL. This study provides a mechanistic view of means to target the signaling mechanisms of immunosuppression to determine potential therapeutic interventions.

Intravenous treatment of Leishmania donovani infected mice with liposomal hexadecylphosphocholine

84%

Kaufmann-Kolle P., Kuhlencord A., Eibl H.

Cellular and Molecular Biology Letters

1996

tom 01

nr 4

Visceral leishmaniasis is a protozoan born disease, which when left untreated, leads to morbidity and mortality in humans. It was demonstrated that orally applied non-liposomal hexadecylphosphocholine exhibits remarkable therapeutic efficacy against leishmanial infections in BALB/c mice. With the added benefit that liposomal hexadecylphosphocholine is better tolerated after oral application and can be repeatedly injected intravenously without causing thrombophlebitis, we show that liposomal hexadecylphosphocholine is much more effective against visceral leishmaniasis than therapy with conventional drugs such as Pentostam®. Most important, the i.v. treatment of infected mice with liposomal hexadecylphosphocholine was the only therapy that was curative.

Ograniczanie wyników

1 Annals of Parasitology

1 Cellular and Molecular Biology Letters

1 Aghazadeh-Dibavar S.

1 Bandyopadhyay M.

1 Dasgupta S.

1 Eibl H.

1 Flora R.

1 Kaufmann-Kolle P.

1 Kuhlencord A.

1 2014

1 1996

Wyniki wyszukiwania

Immunosuppression during Leishmania donovani infection: a potential target for the development of therapy

Intravenous treatment of Leishmania donovani infected mice with liposomal hexadecylphosphocholine