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Macrophages during infection with Trichinella spiralis in mice

100%

Karmanska K., Houszka M., Widyma A., Stefaniak E.

Wiadomości Parazytologiczne

1997

tom 43

nr 3

Behaviour of macrophages in experimental mice trichinellosis, was investigated using the immunoenzymatic technique with monooclonal antibodies CD11b/CD18 within the framework of avidin-biotin-DAB. The maximum and earliest mobilization of macrophages 7 day post infection (dpi) was observed in the lamina propria of the intestinal mucosa. The highest level of macrophages in the muscles tissue was noted on day 21 of infection, however as early as in 28 dpi, their maximum level was observed inside the larval capsules. They line, especially between 35-42 dpi internal capsule surphace.

The cells observed inside capsules of larvae in the course of experimental trichinellosis in mice

100%

Karmanska K., Houszka M., Widyma A.

Wiadomości Parazytologiczne

1997

tom 43

nr 3

In the course of trichinellosis in mice the numerous cells inside larval capsules were observed. Beginning on 14 day post infection (dpi) they were seen in about 7% of infected muscles fibers but at 21 dpi the percentage of capsules with the cells amounted to 77. In the next stage of infection the number of capsules containing cells continued to increase and reach almost 100% at 60 dpi. The identification of the cells was carried out by the indirect immunoenzymatic method using anti-CD4⁺, anti-CD8⁺ and anti-macrophage (Mac-1 antigen) monoclonal antibodies. In course of observation the level of CD4⁺ cells decreased from 11.3 to 0.7, of CD8⁺ from 17.7 to 3.0 and of macrophages from 71.0 to 23.1 %. The most numerous CD4⁺ cells were seen at 14 dpi while the CD8⁺ and macrophages at 21 dpi. Beginning on 28 dpi negatively reacting cells inside larval capsules were also observed. The number of these cells increased from 23.8 to 73.2% at 60 dpi and their identification requires further investigations. The role and the function of all these cells are discussed.

Ograniczanie wyników

2 Wiadomości Parazytologiczne

2 Houszka M.

2 Karmanska K.

2 Widyma A.

1 Stefaniak E.

2 1997

Wyniki wyszukiwania

Macrophages during infection with Trichinella spiralis in mice

The cells observed inside capsules of larvae in the course of experimental trichinellosis in mice