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1

CTLA‑4 expression inversely correlates with kidney function and serum immunoglobulin concentration in patients with primary glomerulonephritides

100%
Grywalska E., Smarz-Widelska I., Mertowski S., Gosik K., Mielnik M., Podgajna M., Abramiuk M., Drop B., Rolinski J., Zaluska W.
Archivum Immunologiae et Therapiae Experimentalis
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2019
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tom 67
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nr 5
2
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Effect of heat exposure on dehydration and kidney function among sea salt workers in Thailand

67%
Luangwilai T., Robson M. G., Siriwong W.
Roczniki Państwowego Zakładu Higieny
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2021
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tom 72
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nr 4
3
Content available remote

Effects of alfacalcidol on the contractile properties of the gastrocnemius medialis muscle in adult and old rats

67%
Testerink J., Degens H., Rittweger J., Shiraishi A., Jaspers R. T., De Haan A.
Journal of Physiology and Pharmacology
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2011
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tom 62
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nr 1
Vitamin D deficiency is associated with muscle weakness. It is unknown, however, how supra-physiological levels of vitamin D affect skeletal muscle. To investigate the effects of increased serum vitamin D (1,25 (OH)2D3 or 1,25D) levels on the contractile properties of the medial gastrocnemius muscle, adult and old female Fischer344 x Brown Norway F1 rats were orally treated with vehicle or the vitamin D analogue alfacalcidol for 1 or 6 weeks. Alfacalcidol treatment resulted in elevated 1,25D serum levels. This was accompanied by hypercalcaemia and a reduction in body mass, the latter largely attributable to a reduced food intake. However, kidney function, as reflected by normal creatinine serum levels, as well as heart mass were unaffected. The 17% reduction in maximal isometric force and power was explicable by a similar loss of muscle mass. The force-frequency relationship of the 6-week-treated old rats was shifted to the left, but neither the shape of the force-velocity relationship nor the fatigability of the muscle were altered. Supra-physiological doses of vitamin D were accompanied by significant reductions in body and muscle mass, but not by an improvement in muscle functioning. Weight loss was largely due to a reduced food intake, while the left shift in the force-frequency relation may be due to increased 1,25D levels.
4
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Investigation of kidney function changes in sea salt workers during harvest season in Thailand

67%
Luangwilai T., Robson M. G., Siriwong W.
Roczniki Państwowego Zakładu Higieny
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2022
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tom 73
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nr 1
Background. Occupational factors have previously been mentioned as contributing to decreased kidney function and the development of chronic kidney disease of unknown cause. Sea salt workers are one of the occupations facing high outdoor temperatures and a highly, intensive workload. Objective. The purpose of the study was to examine whether the kidney function of sea salt workers at the beginning of the harvest season differs from kidney function at the end of the harvest season and to identify factors that can predict the change of kidney function. Material and methods. Data were collected from salt workers (n=50) who were between 18–60 years of age without hypertension, diabetes, and kidney disease in Samut Sakhon province, Thailand. Urine specific gravity (USG) was used for hydration status and the estimated glomerular filter rate (eGFR) was used to measure kidney function. The mixed model was used to find differences over the harvest season and prediction of factors. Results. On average, the eGFR was estimated to decrease by 15.2 ml/min/1.73 m2 over the harvest season. The decline in eGFR of sea salt workers with moderate and heavy workloads were significantly faster than their light workload counterparts after controlling for other covariates. Similarly, dehydration (USG ≥ 1.030) significantly accelerated the rate of kidney function loss. Conclusions. Our study confirmed exposure to heat over the harvest season leads to decreased eGFR in sea salt workers. The rate of change of eGFR could be predicted by workload and hydration status. Workers with dehydration who performed medium to heavy workloads in farms showed faster kidney function decline than those who performed light workload.
5
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High renin arterial hypertension due to occlusion of the adrenal veins in the rat

67%
Abramczyk P., Przybylski J., Lisiecka A., Papierski K., Ciszek B.
Journal of Physiology and Pharmacology
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1995
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tom 46
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nr 1
6
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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The effect of nitrendipine on renal haemodynamics and tubular reabsorption and its neural control in anaesthetised rats with chronic renal failure

59%
Manitius J., Johns E. J., Chamienia A. L.
Journal of Physiology and Pharmacology
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1999
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tom 50
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nr 1
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