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Effect of long-term cadmium treatment on apoptosis and proliferation of rat kidney cells

100%

Plewka D., Nowaczyk G., Plewka A., Brzoska M. M., Szczepanik T., Moniuszko-Jakoniuk J.

Acta Toxicologica

2007

tom 15

nr 2

141-148

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L-arginine decreases heat shock protein 70 [marker of environmental stress] expression in kidney cells of rat fetuses during apoptosis - late effect of adriamycin action

100%

Pedrycz A., Brzeski Z.

Annals of Agricultural and Environmental Medicine

2006

tom 13

nr 1

Both Adriamycin and nitric oxide (NO) cause apoptosis acting through or as free radicals inciting oxidative stress in the cell. However, in some tissues the antiapoptotic action of NO was described, thereby the impact of NO on cell apoptosis is not finally recognized. In this study, a trial of the evaluation of exogenous NO (L-arginine) impact on apoptosis induced by Adriamycin in fetal kidney cells was undertaken. For this reason, the expression of Heat Shock Protein 70 (HSP 70), environmental stress marker, as a sensitive biomarker of oxidative stress induced in fetal kidney cells with Adriamycin given to mothers prior to pregnancy was studied using immunohistochemical method. The expression of HSP 70 in fetal kidney cells, whose mothers received apart from Adriamycin, L-arginine (as NO substrate) was also evaluated. The results of the study pointed to the fact that the exogenous NO (L-arginine) could be helpful in inhibition of intensified apoptosis in fetal cells as a late effect of Adriamycin action.

Overexpression of human osteopontin increases cell proliferation and migration in human embryo kidney-293 cells

80%

Liu Y. J., Zhang D.-Q., Sui X.-M., Tian W.

Cellular and Molecular Biology Letters

2009

tom 14

nr 4

670-678

Malignant tumors are characterized by dysregulated cell growth and the metastasis of secondary tumors. Numerous studies have documented that osteopontin (OPN) plays a key role in regulating tumor progression and metastasis. Here, we show that the overexpression of OPN in human embryo kidney-293 cells significantly increases both the level of cell proliferation, by provoking the G1/S transition, and the level of cell migration in vitro. These findings suggest that augmented OPN contributes to cell growth and motility. Inhibiting OPN or the pathway it stimulates may therefore represent a novel approach for the treatment of primary tumors and associated metastases.

Ograniczanie wyników

1 Acta Toxicologica

1 Annals of Agricultural and Environmental Medicine

1 Cellular and Molecular Biology Letters

1 Brzeski Z.

1 Brzoska M. M.

1 Liu Y. J.

1 Moniuszko-Jakoniuk J.

1 Nowaczyk G.

1 Pedrycz A.

1 Plewka A.

1 Plewka D.

1 Sui X.-M.

1 Szczepanik T.

1 Tian W.

1 Zhang D.-Q.

1 2009

1 2007

1 2006

Wyniki wyszukiwania

Effect of long-term cadmium treatment on apoptosis and proliferation of rat kidney cells

L-arginine decreases heat shock protein 70 [marker of environmental stress] expression in kidney cells of rat fetuses during apoptosis - late effect of adriamycin action

Overexpression of human osteopontin increases cell proliferation and migration in human embryo kidney-293 cells