Several points seem essential for construction of the future statistical theory of biochemical processes. (a) The native proteins involved in these processes reveal a purely stochastic intramolecular dynamics of conformational transitions much slower than the usual vibrational dynamics. At least in the range from 10-11 to 10-7s the relaxation time spectrum of conformational transition dynamics is practically quasi-continuous. (b) The majority of reactions involving proteins are controlled and, presumably, also gated by this stochastic dynamics. (c) Of special importance is the short initial-condition dependent stage of biochemical reactions, neglected in the description of the reaction in terms of the standard kinetics. This stage is directly observed in experiments in which especially prepared initial conformational substates of the protein are confined to the reaction transition state. (d) The initial-condition dependent stage, and not that described by the standard kinetics, is responsible for the coupling of component reactions in the complete catalytic cycles proceeding in the steady-state and more complex processes of biological free energy transduction.
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