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Brain spectrin and friends

100%

Riederer B. M., Wintergerst E. S., Valcourt E., Routtenberg A.

Cellular and Molecular Biology Letters

1996

tom 01

nr 1

Brain spectrin (fodrin, calspectin), is an actin binding protein, and composed of two α- and two β-subunits which combine by head-to-head interaction to a heterotetramere. Together with other proteins it forms a proteinaceous meshwork underlying the cytoplasmic surface of the plasma membrane. In the mammalian brain, three forms of spectrins were identified, an axonal, a somato-dendritic and a astroglial one. A subcellular localization at the electron microscopic-level suggests that these forms are not only attached to membranes but expand into the cytoplasm. It was shown that they differ in their subcellular distribution, and their temporal appearance during postnatal brain development. The subplasmalemmal cytoskeleton is composed of brain spectrin and a variety of proteins such as actin and calmodulin, and we discuss here two additional proteins, FI and parvalbumin, which may bind to brain spectrin and may have to be included in the circle of proteins interacting with brain spectrin.

Postnatal development of NOS-ir neurons in the rat claustrum

100%

Kowianski P., Morys J. M., Wojcik S., Dziewiatkowski J., Morys J.

Folia Morphologica

2003

tom 62

nr 1

The morphological features of nitric oxide synthase (NOS)-containing neurons in the rat claustrum (Cl) were studied during the period of four months after birth. Forty-five animals divided into nine groups, according to survival period (P0, P4, P7, P10, P14, P21, P28, P60, P120) were used in the study. The immunocytochemical staining to neuronal NOS was performed and the material was studied both qualitatively and quantitatively using unbiased stereological methods. Our observations indicate that the process of maturation of NOS-immunoreactive (ir) neurons in Cl takes place during the early postnatal period. We report the increase of numerical density of immunoreactive neurons, changes in neuronal size, expressed by the decrease of the percentage of small neurons with simultaneous increase of the participation of medium-sized neurons and large neurons. In the whole studied period the prevalence of oval and fusiform neurons is observed. However, the increase of the proportion of multipolar neurons takes place. Round neurons are most characteristic in the youngest groups of animals and later become dominated by the developing subpopulations of irneurons of other shapes. In the anterior, central and posterior parts of Cl, a similar pattern of maturation of NOS-ir neurons is observed. No prevalence of characteristically shaped neurons is observed in any part of Cl. The adult-like pattern of morphological features in the NOS-ir neuronal population in Cl is reached in the third postnatal week. The maturation of NOS-ir neurons in the claustrum is a dynamic process which is not stabilised at the moment of birth. It may be assumed that characteristic changes of the NOS-ir population of neurons may be influential on the physiological processes observed in Cl. These may in particular have some importance for the processes of synaptogenesis and establishing as well as refining of numerous claustral connections with the other structures of the central nervous system.

5-HT7 receptors modulate GABAergic transmission in rat hippocampal CA1 area

80%

Tokarski K., Kusek M., Hess G.

Journal of Physiology and Pharmacology

2011

tom 62

nr 5

Ograniczanie wyników

1 Cellular and Molecular Biology Letters

1 Folia Morphologica

1 Journal of Physiology and Pharmacology

1 Dziewiatkowski J.

1 Hess G.

1 Kowianski P.

1 Kusek M.

1 Morys J.

1 Morys J. M.

1 Riederer B. M.

1 Routtenberg A.

1 Tokarski K.

1 Valcourt E.

1 Wintergerst E. S.

1 Wojcik S.

1 2011

1 2003

1 1996

Wyniki wyszukiwania

Brain spectrin and friends

Postnatal development of NOS-ir neurons in the rat claustrum

5-HT7 receptors modulate GABAergic transmission in rat hippocampal CA1 area