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Evaluation of selected indicators of immune response (IL-1B, IL-4, IL-6, SAA and HP) in pigs fed diets containing deoxynivalenol, T-2 toxin, and zearalenone

100%

Zielonka L., Zwierzchowski W., Obremski K., Gajecka M., Jakimiuk E., Gajecki M.

Bulletin of the Veterinary Institute in Puławy

2010

tom 54

nr 4

The objective of this study was to examine the clinical significance of selected indicators of immune response (IL-lß, 1L-4, IL-6. SAA, and Hp) in short-term combined intoxication exposure of pigs to low doses of deoxynivalenol, T-2 toxin, and zearalenone present in naturally contaminated feedstuffs during grain growth. Statistically significant differences were not noted after 14 d of feeding diets contaminated with the above mycotoxins. The mycotoxins did not induce inflammatory processes. The subclinical form of combined mycotoxicosis could be due to incorrect immunological response. The identification of the underlying cause would support the development of new methods for the prevention of combined mycotoxicosis.

Polymorphisms of human IL-1b and IL-1 antagonist genes and their informativity for the association studies

100%

Witas H. W., Mlynarski W., Sychowski R.

Cellular and Molecular Biology Letters

1998

tom 03

nr 4

Several genetic and immunological studies showed that interleukin-1 (IL-1) is involved in pathogenesis of immune-related disorders e.g. type 1 diabetes, autoimmune thyroiditis or inflammatory bowel disease. Association studies performed till now are rather inconclusive, possibly because investigated markers chosen were not enough informative. The aim of the present study is to elucidate how informative for association screening is the occurrence of known polymorphisms located within genes encoding IL-1β (IL-1B) and IL-1 antagonist (IL-1RN) in Polish population. The following substitutions were analyzed by PCR based techniques: T→C within the promotor region, G→A in intron 4 and C→T in exon 5 of IL-1B gene as well as T→C in exon 2, T→C in exon 4 and the polymorphism of variable number of tandem repeats (VNTR) of 86 base pairs within intron 2 of IL-1RN gene. Obtained results proved the occurrence of all studied polymorphisms in Polish population. Combination of haplotypes related to three novel IL-1B gene dimorphisms reveals that PIC value 0.77 (polymorphic information contents) is similar to that of microsatellite markers. Thus, it is possible that the combination of revealed polymorphisms makes together new marker applicable for the genetic association studies more sensitive then markers previously used.

Ograniczanie wyników

1 Bulletin of the Veterinary Institute in Puławy

1 Cellular and Molecular Biology Letters

1 Gajecka M.

1 Gajecki M.

1 Jakimiuk E.

1 Mlynarski W.

1 Obremski K.

1 Sychowski R.

1 Witas H. W.

1 Zielonka L.

1 Zwierzchowski W.

1 2010

1 1998

Wyniki wyszukiwania

Evaluation of selected indicators of immune response (IL-1B, IL-4, IL-6, SAA and HP) in pigs fed diets containing deoxynivalenol, T-2 toxin, and zearalenone

Polymorphisms of human IL-1b and IL-1 antagonist genes and their informativity for the association studies