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Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

QS - systems communication of Gram-negative bacterial cells

100%

Ziemichod A., Skotarczak B.

Acta Biologica

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2017

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tom 24

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Plant signalling peptides

100%

Wisniewska J., Trejgell A., Tretyn A.

Acta Physiologiae Plantarum

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2003

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tom 25

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nr 1

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Influences of Lovastatin on membrane ion flow and intracellular signalling in breast cancer cells

100%

Wei N., Mi M. T., Zhou Y.

Cellular and Molecular Biology Letters

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2007

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tom 12

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nr 1

Lovastatin, an inhibitor of cellular cholesterol synthesis, has an apparent anti-cancer property, but the detailed mechanisms of its anti-cancer effects remain poorly understood. We investigated the molecular mechanism of Lovastatin anti-tumor function through the study of its effect on membrane ion flow, gap junctional intercellular communication (GJIC), and the pathways of related signals in MCF-7 mammary cancer cells. After treatment for 24–72 h with 4, 8 or 16 μmol/L Lovastatin, cellular proliferation was examined via the MTT assay, and changes in membrane potential and cellular [Ca2+]i were monitored using confocal laser microscopy. In addition, the expression of plasma membrane calcium ATPase isoform 1 (PMCA1) mRNA was analyzed via RT-PCR, the GJIC function was examined using the scrape-loading dye transfer (SLDT) technique, and MAPK phosphorylation levels were tested with the kinase activity assay. The results showed that Lovastatin treatment significantly inhibited the growth of MCF-7 breast cancer cells. It also increased the negative value of the membrane potential, leading to the hyperpolarization of cells. Moreover, Lovastatin treatment continuously enhanced [Ca2+]i, although the levels of PMCA1 mRNA were unchanged. GJIC was also upregulated in MCF-7 cells, with transfer of LY Fluorescence reaching 4 to 5 rows of cells from the scraped line after treatment with 16 μmol/L Lovastatin for 72 h. Finally, downregulation of ERK1 and p38MAPK phosphorylation were found in Lovastatin-treated MCF-7 cells. It could be deduced that Lovastatin can induce changes in cellular hyperpolarization and intracellular Ca2+ distributions, and increase GJIC function. These effects may result in changes in the downstream signal cascade, inhibiting the growth of MCF-7 cells.

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Early effect of ethylene glycol on gap junctional intercellular communication

100%

Vitek J. A.

Folia Histochemica et Cytobiologica. Supplement

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1997

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tom 35

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nr 2

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Microvesicles in health and disease

80%

Inal J. M., Ansa-Addo E. A., Stratton D., Kholia S., Antwi-Baffour S. S., Jorfi S., Lange S.

Archivum Immunologiae et Therapiae Experimentalis

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2012

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tom 60

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nr 2

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Apoplastic system of the gynoecium and embryo sac in relation to function

80%

Yang H. Y.

Acta Biologica Cracoviensia. Series Botanica

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2001

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tom 43

This article addresses the gynoecium and embryo sac from a fresh viewpoint, that is, in terms of the apoplastic system involved in the pistil and its putative functions in sexual processes. This system includes the extracellular matrix of the pollen tube track and particularly the micropyle and synergids, the intercellular space between the cells of the female germ unit, and the apoplast surrounding the embryo sac. Most of the data cited are research results established during the last decade, mainly from ultrastructural and cytochemical observations, which give interesting and important information about the apoplastic system concerned.

Ograniczanie wyników

1 Acta Biologica

1 Acta Biologica Cracoviensia. Series Botanica

1 Acta Physiologiae Plantarum

1 Archivum Immunologiae et Therapiae Experimentalis

1 Cellular and Molecular Biology Letters

1 Folia Histochemica et Cytobiologica. Supplement

1 Ansa-Addo E. A.

1 Antwi-Baffour S. S.

1 Inal J. M.

1 Jorfi S.

1 Kholia S.

1 Lange S.

1 Mi M. T.

1 Skotarczak B.

1 Stratton D.

1 Trejgell A.

1 Tretyn A.

1 Vitek J. A.

1 Wei N.

1 Wisniewska J.

1 Yang H. Y.

1 Zhou Y.

1 Ziemichod A.

1 2017

1 2012

1 2007

1 2003

1 2001

1 1997

QS - systems communication of Gram-negative bacterial cells

Plant signalling peptides

Influences of Lovastatin on membrane ion flow and intracellular signalling in breast cancer cells

Early effect of ethylene glycol on gap junctional intercellular communication

Microvesicles in health and disease

Apoplastic system of the gynoecium and embryo sac in relation to function