Wyniki wyszukiwania

1

Spiculated red blood cells induced by intercalation of amphiphiles

100%

Iglic A., Kralj-Iglic V., Hagerstrand H.

Cellular and Molecular Biology Letters

|

1998

|

tom 03

|

nr 2

2

The geometry of intercalation complex of antitumor mitoxantrone and ametantrone with DNA: Molecular dynamics simulations

75%

Mazerski J., Martelli S., Borowski E.

Acta Biochimica Polonica

|

1998

|

tom 45

|

nr 1

Intercalative binding of the antitumor drugs ametantrone and mitoxantrone to the dodecamer duplex d(CGCGAGCTCGCG)2 was studied by applying molecular dynamics in water with the GROMOS 87 force field. A number of reasonable binding orientations were tested by short pre-simulations. It was shown that in energetically favorable orientation the anthraquinone chromophore is perpendicular to the direction of inter-base hydrogen bonds. Helically shaped side-chains of the drugs fit to the minor groove. The best orientation obtained in pre-simulations was applied in the main simulations. Small but significant differences were found between structures of intercalation complexes of the two drugs with the dodecamer duplex, the mitoxantrone complex possessing more favorable energy. The molecular nature of interactions responsible for those differences has been discussed.

3

New aspects of pathogenesis of atrial fibrillation: remodeling of intercalated discs

63%

Tribulova N., Egan Benova T., Szeiffova Bacova B., Viczenczova C., Barancik M.

Journal of Physiology and Pharmacology

|

2015

|

tom 66

|

nr 5

4

Transcription factors as targets of anticancer drugs

63%

Gniazdowski M., Czyz M.

Acta Biochimica Polonica

|

1999

|

tom 46

|

nr 2

Several general and gene- and cell-selective transcription factors are required for specific transcription to occur. Many of them exert their functions through specific contacts either in the promoter region or at distant sequences regulating the initiation. These contacts may be altered by anticancer drugs which form non-covalent complexes with DNA. Covalent modifications of DNA by alkylating agents may prevent transcription factors from recognizing their specific sequences or may constitute multiple "unnatural" sites in DNA which attract the factors thus decreasing their availability in the cell. The anticancer drug-transcription factor interplay which is based on specific interactions with DNA may contribute to pharmacological properties of the former and provide a basis for the search for new drugs.

Ograniczanie wyników

2 Acta Biochimica Polonica

1 Cellular and Molecular Biology Letters

1 Journal of Physiology and Pharmacology

1 Barancik M.

1 Borowski E.

1 Czyz M.

1 Egan Benova T.

1 Gniazdowski M.

1 Hagerstrand H.

1 Iglic A.

1 Kralj-Iglic V.

1 Martelli S.

1 Mazerski J.

1 Szeiffova Bacova B.

1 Tribulova N.

1 Viczenczova C.

1 2015

1 1999

2 1998

Spiculated red blood cells induced by intercalation of amphiphiles

The geometry of intercalation complex of antitumor mitoxantrone and ametantrone with DNA: Molecular dynamics simulations

New aspects of pathogenesis of atrial fibrillation: remodeling of intercalated discs

Transcription factors as targets of anticancer drugs