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1

Studies on the adaptation of influenza virus replicated at low temperature. III. Biochemical studies

100%
Brydak L.
Acta Microbiologica Polonica
|
1990
|
tom 39
|
nr 1-2
2

Influenza virus hemagglutinin as a vaccine antigen produced in bacteria

88%
Saczynska V.
Acta Biochimica Polonica
|
2014
|
tom 61
|
nr 3
3

A universal flu vaccine

88%
Kesik-Brodacka M., Plucienniczak G.
Acta Biochimica Polonica
|
2014
|
tom 61
|
nr 3
4

Structural biology of the influenza virus fusion peptide

88%
Worch R.
Acta Biochimica Polonica
|
2014
|
tom 61
|
nr 3
5

Influenza viruses resistant to neuraminidase inhibitors

88%
Nitsch-Osuch A., Brydak L. B.
Acta Biochimica Polonica
|
2014
|
tom 61
|
nr 3
6

The role of target membrane sialic acid residues in the fusion activity of the influenza virus: the effect of two types of ganglioside on the kinetics of membrane merging

88%
Ramalho-Santos J., Pedroso De Lima M. C.
Cellular and Molecular Biology Letters
|
2004
|
tom 09
|
nr 2
The influenza virus enters target cells via the action of hemagglutinin proteins (HA) inserted into the viral envelope. HA promotes membrane fusion between the viral envelope and endosomal membrane at low pH, following viral binding to sialic acid-containing receptors on target cells, and internalization by endocytosis. The effect of target membrane sialic acid residues on the fusion activity of the influenza virus towards model membranes was evaluated by both reduction, (i.e. treating somatic cells with neuraminidase- (NA-) prior to virus-cell interactions), and by supplementing liposomes with the gangliosides GD1a and GT1b. The harshness of the neuraminidase pretreatment of target cells required to affect virus-induced membrane merging was found to greatly depend on the assay conditions, i.e. whether a virus-cell prebinding step at neutral pH was included prior to acidification. Minor concentrations of neuraminidase were found to greatly reduce virus fusion, but only in the absence of a prebinding step; they had no effect if this step was included. Although membrane merging was greatly reduced following cell neuraminidase pretreatment, virus-cell association at low pH was not disturbed proportionately. This probably reflects unspecific virus-cell binding under these conditions, probably of inactivated or aggregated virus particles, which does not translate into membrane merging. This seems to suggest both that target membrane sialic acid can protect the virus from losing its activity before triggering membrane merging, and that the importance of this interaction is not merely to ensure virus-target proximity. With liposomes, we found that both types of ganglioside supported efficient fusion, with GD1a promoting a slightly faster initial rate. However, in this case, virus-target proximity closely mirrored fusion activity, thus pointing to differential specificity between targets routinely used to assay influenza virus fusion activity.
7

Antiviral activity of novel oseltamivir derivatives against some influenza virus strains

75%
Kocik J., Kolodziej M., Joniec J., Kwiatek M., Bartoszcze M.
Acta Biochimica Polonica
|
2014
|
tom 61
|
nr 3
8

A clinical utility of a strip test for influenza A/B and comparison with detection by RT PCR

75%
Miarka M., Horban A., Maliszewska H., Bilinski P., Prus-Kowalczuk W.
Acta Biochimica Polonica
|
2014
|
tom 61
|
nr 3
9

Detection and differentiation of Newcastle disease virus and influenza virus by using duplex real-time PCR

75%
Nidzworski D., Wasilewska E., Smietanka K., Szewczyk B., Minta Z.
Acta Biochimica Polonica
|
2013
|
tom 60
|
nr 3
 Newcastle disease virus (NDV), member of the Paramyxoviridae family and avian influenza virus (AIV), member of the Orthomyxoviridae family, are two main avian pathogens causing serious economic problems in poultry health. Both are enveloped, single-stranded, negative-sense RNA viruses and cause similar symptoms, ranging from sub-clinical infections to severe diseases, including decrease in egg production, acute respiratory syndrome, and high mortality. Similar symptoms hinder the differentiation of infection with the two viruses by standard veterinary procedures like clinical examination or necropsy. To overcome this problem, we have developed a new duplex real-time PCR assay for the detection and differentiation of these two viruses. Eighteen NDV strains, fourteen AIV strains, and twelve other (negative control) strains viruses were isolated from allantoic fluids of specific pathogen-free (SPF), embryonated eggs. Four-weeks-old SPF chickens were co-infected with both viruses (NDV - LaSota and AIV - H7N1). Swabs from cloaca and trachea were collected and examined. The results obtained in this study show that by using duplex real-time PCR, it was possible to detect and distinguish both viruses within less than three hours and with high sensitivity, even in case a bird was co-infected. Additionally, the results show the applicability of the real-time PCR assay in laboratory practice for the identification and differentiation of Newcastle disease and influenza A viruses in birds.
10

Antivirals - current trends in fighting influenza

75%
Krol E., Rychlowska M., Szewczyk B.
Acta Biochimica Polonica
|
2014
|
tom 61
|
nr 3
11

Detection of the influenza virus yesterday and now

75%
Wozniak-Kosek A., Kempinska-Miroslawska B., Hoser G.
Acta Biochimica Polonica
|
2014
|
tom 61
|
nr 3
12

In vivo reassortment of influenza viruses

75%
Urbaniak K., Markowska-Daniel I.
Acta Biochimica Polonica
|
2014
|
tom 61
|
nr 3
13

Caveolae as an additional route for influenza virus endocytosis in MDCK cells

75%
Nunes-Correia I., Eulalio A., Nir S., Pedroso de Lima M. C.
Cellular and Molecular Biology Letters
|
2004
|
tom 09
|
nr 1
Clathrin-mediated endocytosis has been described as the primary internalization pathway for many viruses, including the influenza virus. However, caveolae, an alternative clathrin-independent endocytotic pathway, has also been described as mediating the entry of some molecules, including viruses. To address the question of pathway selection by the influenza virus, we have investigated whether the virus is internalized via clathrin-coated pits and/or caveolae in Madin Darby canine kidney (MDCK) cells. By applying pharmacological manipulations to selectively disrupt the cell internalization pathways, we found that, in MDCK cells, the influenza virus may be internalized via caveolae in addition to entry by clathrin-mediated endocytosis. However, a small contribution by another mode of entry, as recently proposed [Sieczkarski, S.B. and Whittaker, G.R., J. Virol. 76 (2002) 10455-10464], cannot be excluded.
14

Lactococcus lactis IBB477 presenting adhesive and mucoadhesive properties as a candidate carrier strain for oral vaccination against influenza virus

63%
Radziwill-Bienkowska J. M., Zochowska D., Bardowski J., Mercier-Bonin M., Kowalczyk M.
Acta Biochimica Polonica
|
2014
|
tom 61
|
nr 3
15

Mapping of the influenza A hemagglutinin serotypes evolution by the ISSCOR method

63%
Radomski J. P., Slonimski P. P., Zagorski-Ostoja W., Borowicz P.
Acta Biochimica Polonica
|
2014
|
tom 61
|
nr 3
16

Plant expression systems for production of hemagglutinin as a vaccine against influenza virus

63%
Redkiewicz P., Sirko A., Kamel K. A., Gora-Sochacka A.
Acta Biochimica Polonica
|
2014
|
tom 61
|
nr 3
17

Native nucleic acid electrophoresis as an efficient alternative for genotyping method of influenza virus

63%
Pajak B., Lepek K.
Acta Biochimica Polonica
|
2014
|
tom 61
|
nr 3
18

Studies on the adaptation of influenza virus replicated at low temperature. V. Isoelectric focusing studies

63%
Brydak L.
Acta Microbiologica Polonica
|
1993
|
tom 42
|
nr 1
19
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Kinetics of replication of equine influenza viruses in chicken embryos and selected cell lines

63%
Rozek W., Skulmowska-Kryszkowska D., Zmudzinski J. F.
Bulletin of the Veterinary Institute in Puławy
|
1998
|
tom 42
|
nr 1
The kinetics of replication of equine influenza A1 and A2 viruses in different systems e.g. chicken embryos, Vero, MDCK and MDBK cell lines was evaluated. The strains A/Equi/1/Praque 56 and A/Equi/2/Kentucky 81 were used. A dose of 0.2 ml of influenza A1 and A2 viruses with the haemagglutinin titre (HA) 256 diluted to 10⁻³ and 10⁻⁴ respectively, was found out to be optimal for inoculation of chicken embryos. The highest HA titre for viruses A1 and A2 were noticed after a 72 hours of incubation post inoculation. The ID₅₀ and LD₅₀ titres differed by more than 2 log in case of A1 virus. Both equine influenza viruses replicated in Vero, MDCK and MDBK cells; however, MDCK cells have revealed the highest sensitivity to infection. Low haemagglutinin titres found in the medium from infected cell lines have suggested that this is rather poor source of virus antigens for vaccine production.
20

Evaluation of immunological status of horses against influenza virus based on the presence of antibodies against NS1 and M1 proteins

63%
Rozek W., Polak M. P., Zmudzinski J. F.
Bulletin of the Veterinary Institute in Puławy
|
2003
|
tom 47
|
nr 2
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