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Indocyanine green as a prospective sensitizer for photodynamic therapy of melanomas

100%

Urbanska K., Romanowska-Dixon B., Matuszak Z., Oszajca J., Nowak-Sliwinska P., Stochel G.

Acta Biochimica Polonica

2002

tom 49

nr 2

Spectroscopic, photochemical and biological properties of indocyanine green (ICG) are presented. Light over 800 nm is effectively absorbed by ICG. This property as well as photochemical behaviour of ICG make it a very suitable dye for photodynamic treatment of melanoma cells. Cytotoxicity of ICG itself and the effect of photodynamic therapy (PDT) were evaluated by following the growth of human (SKMEL 188) and mouse (S91) melanoma cells. The surviving fraction of the cells irradiated (λex = 830 nm) vs non-irradiated, treated with the same dose of ICG, is significantly decreased (5- to 10-fold). These results show that ICG is a very promising dye for photodynamic therapy of melanomas.

Combined effects of radiotherapy and photodynamic therapy on an in vitro human prostate model

100%

Colasanti A., Kisslinger A., Quarto M., Riccio P.

Acta Biochimica Polonica

2004

tom 51

nr 4

Human prostate cancer cells were evaluated for growth after photodynamic therapy, radiotherapy, and combined treatment. Indocyanine green was tested as a photosensitizer and radiosensitizer. Two human cell lines were used: PC-3 derived from prostate carcinoma, and EPN derived from normal prostate tissue. The light source used for the photoactivation experiments was a diode laser peaked at 805 nm. The light dose incident on cells was 108 J/cm2. Ionizing radiation was produced by a linear accelerator, and the dose was 2, 4 and 6 Gy. Cytotoxicity was evaluated by measuring the colony forming ability of cells. Our results show that indocyanine green induces cell death by photoactivation, but it does not act as a radiosensitizer if used with ionizing radiation. The combined treatment of photodynamic therapy and radiotherapy produces an additive effect which does not depend on the sequence of the two treatments. Combined treatments could be more useful since they allow the reduction of the ionizing radiation

Ograniczanie wyników

2 Acta Biochimica Polonica

1 Colasanti A.

1 Kisslinger A.

1 Matuszak Z.

1 Nowak-Sliwinska P.

1 Oszajca J.

1 Quarto M.

1 Riccio P.

1 Romanowska-Dixon B.

1 Stochel G.

1 Urbanska K.

1 2004

1 2002

Wyniki wyszukiwania

Indocyanine green as a prospective sensitizer for photodynamic therapy of melanomas

Combined effects of radiotherapy and photodynamic therapy on an in vitro human prostate model