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Design, synthesis and biological evaluation of a new bridged immunosuppressor

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Szewczuk Z., Wilczynski A., Petry I., Siemion I. Z., Wieczorek Z.

Acta Biochimica Polonica

2001

tom 48

nr 4

A bridged peptide with the sequence: H-Thr-Pro-Gln-Arg-Gly-Asp-Val-y-Abu-Asn- Asp-Gln-Glu-Glu-Thr-Thr-Gly-Val-Val-Ser-Thr-Pro-Leu-Ile-Arg-Asn-Gly-OH was designed to mimic the discontinuous epitope of the HLA-DQ molecule that might interact with CD4. The bridged peptide revealed distinct suppressory effect in the humoral immune response. This result supports our suggestion that the 164-172 region of the HLA-DQ molecule may enhance its interactions with coreceptors, possibly with CD4.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Petry I.

1 Siemion I. Z.

1 Szewczuk Z.

1 Wieczorek Z.

1 Wilczynski A.

1 2001

Wyniki wyszukiwania

Design, synthesis and biological evaluation of a new bridged immunosuppressor