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1

Immunomodulatory effects of Panax ginseng preparations on the mouse

100%
Rogala E., Sommer E., Radomska-Lesniewska D., Sawicka T., Prosinska J., Drozd J., Bialas-Chromiec B., Filewska M., Skopinska-Rozewska E.
Herba Polonica
|
2004
|
tom 50
|
nr 1
The immunomodulatory effect of two preparations from Panax ginseng radix, namely Ginsengcha (granulated mass of radix ginseng) and Ginsengpian (ginseng radix flakes) on mice has been investigated. The examined immune parameters were the following: the production of anti-SRBC antibodies, the chemokinesis of mouse spleen cells and the graft-versus-host reaction induced by mouse spleen cells. Additionally, the influence of ginseng preparations on the angiogenic activity of syngeneic LI sarcoma cells, LI sarcoma tumour growth and tumour blood supply (haemoglobin content) was examined. The production of antibodies was enhanced, particularly in the group with lower control parameters (pcO.OOl). Chemokinesis proved to be augmented (p<0.001) after 10 days of administering ginseng preparations to mice. The ability of mouse spleen cells to produce immunological mediators in the GvH reaction (immunological angiogenesis) turned out to increase significantly (p<0.001) under the influence of Ginsengcha. Neither Ginsengpian nor Ginsengcha stimulated the angiogenic activity of the LI sarcoma cells. Ginsengpian sligtly decreased this activity (p<0.02). The LI sarcoma tumour volume was significantly reduced by Ginsengcha (p<0.05), but no influence on tumour blood supply was observed. Panax ginseng preparations possess immunomodulatory properties and show potent antitumour activity.
2

Evaluation of the immunomodulatory activity of four compounds exerting antimutagenic effects on human lymphocytes in vitro

86%
Gasiorowski K., Brokus B., Tabaka H.
Cellular and Molecular Biology Letters
|
2000
|
tom 05
|
nr 4
469-481
Four compounds previously described as antimutagenic for human lymphocytes in vitro were tested on their immunomodulatory activity in lymphocyte cultures. The standard immunocytochemical methods were applied for microscopic examination of the percentual representation of the main lymphocyte subpopulation. The results imply that all of the tested compounds exhibited significant immunomodulatory effect, with that of fluphenazine being the strongest, whereas that of todralazine is the weakest. Two of the tested compounds: anthocyanins from Aronia melanocarpa fruit, and alkylresorcinols from cereal grains, also exhibited a distinct immunomodulatory activity, and it deserves adequate attention as an activity exerted by natural products, commonly present in regular human diet. The analysis of the proliferating cell fraction, and the estimation of the cell proliferation rate suggest that the effect of the tested compounds might depend on an increase in the number of lymphocytes which expressed their differentiation antigens on the cell membranes.
3

The immunomodulatory effect of CCA (N-(2-carboxyphenyl)-4-chloroanthranilic acid disodium salt) on IgG antibody response in mice immunized with ovalbumin

86%
Gonzalez R., Wyczolkowska J.
Archivum Immunologiae et Therapiae Experimentalis
|
1989
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tom 37
|
nr 3-4
4

Effect of oral administration involving a probiotic strain of Lactobacillus reuteri on pro-inflammatory cytokine response in patients with chronic periodontitis

72%
Szkaradkiewicz A. K., Stopa J., Karpinski T. M.
Archivum Immunologiae et Therapiae Experimentalis
|
2014
|
tom 62
|
nr 6
5

Sildenafil, a phosphodiesterase type 5 inhibitor, downregulates osteopontin in human peripheral blood mononuclear cells

72%
Kaleta B., Boguska A.
Archivum Immunologiae et Therapiae Experimentalis
|
2017
|
tom 65
|
nr 4
6

Echinacea purpurea extract (cichoric acid) exerts an anti-inflammatory effect on yak PBMCs and regulates the TLR4 signalling pathway

72%
Xue C.-H., A S.-X., Wang M.-J., Wu Q., Liu J.-H., Zhang L.-F., Wu Y., Wu H., Chai S.-T.
Journal of Veterinary Research
|
2021
|
tom 65
|
nr 1
7
Content available remote

Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis

58%
Chojnacki C., Wisniewska-Jarosinska M., Walecka-Kapica E., Klupinska G., Jaworek J., Chojnacki J.
Journal of Physiology and Pharmacology
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2011
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tom 62
|
nr 3
Ulcerative colitis (UC) is a chronic disease characterized by the variable clinical picture with the inflammatory changes which can involve the whole colon or its distal part. The current treatments for UC are mostly nonspecific, not always effective, and often accompanied by serious side effects. Therefore, there is a considerable interest in finding alternative and more tolerable treatments for this serious disease. Several lines of experimental studies have shown that melatonin (MEL) regulates the extensive gut immune system and exerts antiinflammatory and immunomodulatory effects suggesting its beneficial action in UC by reducing and controlling inflammation. The study aimed at evaluating the effect of MEL on the activity of inflammatory process and sustaining the remission in patients with UC. It comprised 60 patients with left-sided UC, divided in two equal groups of 30 patients each (38 women and 22 men, aged 26-49 years), similar in both groups, who were in clinical remission for the last 12 months. Patients, during a next period of 12 months, were given mesalazine in daily doses 2 x 1.0 g and melatonin 5 mg daily at bedtime (group I) or placebo (group II). All the patients on MEL adjuvant treatment remained in remission during 12 months of observation with The Mayo Clinic Disease Activity Index (MCDAI) values 1.50±0.51 at the beginning and 2.75±1.86 points after 12 months. In the placebo group significantly higher MCDAI values were observed than in patients on MEL after 6, 9 and 12 months. At the inclusion MCDAI was 1.61±0.68 points and at the end of observation it reached the value of 5.10±2.22 points. In MEL group CRP level remained within the normal range during the course of the study (from 3.49±1.40 to 4.17±2.10 mg/dl). Whereas in the placebo group from the end of the third month the steady rise in CRP blood concentration was noted from 3.85±1.29 to 13.13±6.08 mg/dl. Parallelly to CRP rise a significant decrease in hemoglobin concentration in blood from 12.05±0.69 to 10.93±0.81 g/dl was observed in patients receiving placebo and the values significantly differed between the groups after 3 (p<0.05), 6, 9 and 12 months (p<0.01). The level of anxiety and the intensity of depression in patients on adjuvant MEL decreased during the study but there were no statistical differences noted between the groups. The results of the study allowed drawing the conclusion that adjuvant melatonin therapy may help in sustaining remission in patients with UC.
8

Immunomodulatory effects of IFN-beta and lovastatin on immunophenotype of monocyte-derived dendritic cells in multiple sclerosis

58%
Bartosik-Psujek H., Tabarkiewicz J., Pocinska K., Radej S., Stelmasiak Z., Rolinski J.
Archivum Immunologiae et Therapiae Experimentalis
|
2010
|
tom 58
|
nr 4
313-319
9

Immunomodulatory effects of HMG-CoA reductase inhibitors

58%
Danesh F. R., Anel R. L., Zeng L., Lomasney J., Sahai A., Kanwar Y. S.
Archivum Immunologiae et Therapiae Experimentalis
|
2003
|
tom 51
|
nr 3
10

Phytochemical and pharmacological investigations on mangiferin

44%
Singh S. K., Sharma V. K., Kumar Y., Kumar S. S., Sinha S. K.
Herba Polonica
|
2009
|
tom 55
|
nr 1
126-139
Mangiferin, a C-glucopyranoside of 1, 3, 6, 7-tetrahydroxyxanthone, has been isolated from various parts of Mangifera indica (Anacardiaceae). The conclusive structure of mangiferin has been established by various researchers using a wide range of chemical and spectral analytical techniques. Mangiferin has been traditionally used in some parts of world as anti-inflammatory, analgesic, antipyretic, antioxidant, immunomodulator, antitumor, antiviral, and anthelminthic and in obesity treatment. The present article is an attempt to encompass various aspects and details related to the characterization of mangiferin and its subsequent pharmacological screening. The literature data on mangiferin has been comprehensively reviewed and evaluated by the authors and hence, the article contains brief description of phytochemical and pharmacological investigations conducted on mangiferin till now and thus may prove as a guiding force for further research in this particular area.
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