Wyniki wyszukiwania

1

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

MicroRNAs as new immunity regulators in viral and bacterial infections

100%

Szumna M., Hukowska-Szematowicz B.

Acta Biologica

|

2020

|

tom 27

2

Vaccine delivery systems and immune regulation in modern immunization

86%

Babiuk L. A.

Bulletin of the Veterinary Institute in Puławy

|

1998

|

tom 42

|

nr 1

3

Nitric oxide and superoxide in inflammation and immune regulation

86%

Guzik T. J., Korbut R., Adamek-Guzik T.

Journal of Physiology and Pharmacology

|

2003

|

tom 54

|

nr 4

Nitric oxide (NO) and reactive oxygen species exert multiple modulating effects on inflammation and play a key role in the regulation of immune responses. They affect virtually every step of the development of inflammation. Low concentrations of nitric oxide produced by constitutive and neuronal nitric oxide synthases inhibit adhesion molecule expression, cytokine and chemokine synthesis and leukocyte adhesion and transmigration. Large amounts of NO, generated primarily by iNOS can be toxic and pro-inflammatory. Actions of nitric oxide are however not dependent primarily on the enzymatic source, but rather on the cellular context, NO concentration (dependent on the distance from NO source) and initial priming of immune cells. These observations may explain difficulties in determining the exact role of NO in Th1 and Th2 lymphocyte balance in normal immune responses and in allergic disease. Similarly superoxide anion produced by NAD(P)H oxidases present in all cell types participating in inflammation (leukocytes, endothelial and other vascular cells etc) may lead to toxic effects, when produced at high levels during oxidative burst, but may also modulate inflammation in a far more discrete way, when continuously produced at low levels by NOXs (non-phagocytic oxidases). The effects of both nitric oxide and superoxide in immune regulation are exerted through multiple mechanisms, which include interaction with cell signalling systems like cGMP, cAMP, G-protein, JAK/STAT or MAPK dependent signal transduction pathways. They may also lead to modification of transcription factors activity and in this way modulate the expression of multiple other mediators of inflammation. Moreover genetic polymorphisms exist within genes encoding enzymes producing both NO and superoxide. The potential role of these polymorphisms in inflammation and susceptibility to infection is discussed. Along with studies showing increasing role of NO and free radicals in mediating inflammatory responses drugs which interfere with these systems are being introduced in the treatment of inflammation. These include statins, angiotensin receptor blockers, NAD(P)H oxidase inhibitors, NO-aspirin and others. In conclusion in this mini-review we discuss the mechanisms of nitric oxide and superoxide dependent modulation of inflammatory reactions in experimental animals and humans. We also discuss potential roles of nitric oxide as a mediator of allergic inflammation.

4

Complement: coming full circle

72%

Le Friec G., Kemper C.

Archivum Immunologiae et Therapiae Experimentalis

|

2009

|

tom 57

|

nr 6

393-407

5

The regulating function of heterotrimeric G proteins in the immune system

72%

Wang Y., Li Y., Shi G.

Archivum Immunologiae et Therapiae Experimentalis

|

2013

|

tom 61

|

nr 4

6

Chitin, a key factor in immune regulation: lesson from infection with fungi and chitin bearing parasites

72%

Brodaczewska K., Donskow-Lysoniewska K., Doligalska M.

Acta Parasitologica

|

2015

|

tom 60

|

nr 2

7

NADPH oxidase and uncoupled nitric oxide synthase are major sources of reactive oxygen species in oral squamous cell carcinoma. Potential implications for immune regulation under high oxidative stress conditions.

72%

Czesnikiewicz-Guzik M., Lorkowska B., Zapala J., Czajka M., Szuta M., Loster B., Guzik T. J., Korbut R.

Journal of Physiology and Pharmacology

|

2008

|

tom 59

|

nr 1

The development of cancer is associated with high oxidative stress and at the same time with immune system activation. Tumors develop efficient mechanisms of protection against the immune response, which allow them to escape the immune surveillance. Simultaneously, key events in the process of carcinogenesis are related to oxidative stress. The relationship between the two remains unknown. Novel understanding of oxidative stress shows that discrete changes of activities of certain enzyme systems such as NADPH oxidases or nitric oxide synthases may be more important than the overall balance of production and removal of reactive oxygen species. Such imbalance of nitric oxide and superoxide production could modify inflammation and immune regulation. We studied superoxide anion production (by lucigenin enhanced chemiluminescence - 5 µM), NADPH oxidase activity and nitric oxide synthase (NOS) dysfunction. In parallel mRNA expression of immunomodulatory markers such as FoxP3 (T regulatory cell marker), CCR6 (mucosal homing effector T cell marker) and CD85j (NK cell/CD8 T cell Ig-like MHC class I inhibitory receptor) was determined. Basal superoxide production and NADPH oxidase activity are increased in oral squamous cell carcinoma. Tumor superoxide production was inhibited by NADPH oxidase inhibitor apocynin and by NOS inhibitor L-NAME. This indicates, for the first time, that oral squamous cell carcinoma is characterized by dysregulated nitric oxide synthase, which apart from increased NADPH oxidase activity contributes to oxidative stress and may be related to the immuno-pathology of these tumors. Studied tumors were infiltrated by CCR6+, but showed lower expression of both CD85j and FoxP3 mRNA. Finally, the CD85j mRNA expression was inversely correlated to oxidative stress parameters. These preliminary studies indicate that tumor oxidative stress, related to NADPH oxidase activity and NOS activity could be related to immune responses to cancer, thus therapeutic modification of oxidative stress, which could include the correction of NOS dysfunction, could facilitate immune surveillance.

8

Treatment of autoimmune disease: time for a paradigm shift?

72%

Mor F.

Archivum Immunologiae et Therapiae Experimentalis

|

2007

|

tom 55

|

nr 1

9

Perivascular adipose tissue as a messenger of the brain-vessel axis: role in vascular inflammation and dysfunction

72%

Guzik T. J., Marvar P. J., Czesnikiewicz-Guzik M., Korbut R.

Journal of Physiology and Pharmacology

|

2007

|

tom 58

|

nr 4

10

Immune regulation by sphingosine 1-phosphate and its receptors

58%

Bode C., Graler M. H.

Archivum Immunologiae et Therapiae Experimentalis

|

2012

|

tom 60

|

nr 1

11

Expanding diversity and common goal of regulatory T and B cells. II: in allergy, malignancy, and transplantation

58%

Korczak-Kowalska G., Stelmaszczyk-Emmel A., Bocian K., Kiernozek E., Drela N., Domagala-Kulawik J.

Archivum Immunologiae et Therapiae Experimentalis

|

2017

|

tom 65

|

nr 6

Ograniczanie wyników

MicroRNAs as new immunity regulators in viral and bacterial infections

Vaccine delivery systems and immune regulation in modern immunization

Nitric oxide and superoxide in inflammation and immune regulation

Complement: coming full circle

The regulating function of heterotrimeric G proteins in the immune system

Chitin, a key factor in immune regulation: lesson from infection with fungi and chitin bearing parasites

NADPH oxidase and uncoupled nitric oxide synthase are major sources of reactive oxygen species in oral squamous cell carcinoma. Potential implications for immune regulation under high oxidative stress conditions.

Treatment of autoimmune disease: time for a paradigm shift?

Perivascular adipose tissue as a messenger of the brain-vessel axis: role in vascular inflammation and dysfunction

Immune regulation by sphingosine 1-phosphate and its receptors

Expanding diversity and common goal of regulatory T and B cells. II: in allergy, malignancy, and transplantation