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Potential suppressor gene loci and human prostate neoplasms

100%

Brys M., Krajewska W. M.

Cellular and Molecular Biology Letters

1997

tom 02

nr 4

The biology of prostate cancer is still poorly understood. Allelic loss studies indicate that there likely exist multiple sites harbouring candidate tumour suppressor genes (TSG), some of which may have an important role in primary tumours, and some in late stages of prostate cancer. The recent studies on the localization of potential TSG in neoplastic transformation of prostate comprise chromosome regions 7q, 8p, l0p/q, 16q, 17q, and 18q. In connection with accumulation of genetic changes affecting functioning of critical TSG, the multistep cancer progression hypothesis is a useful starting point in efforts to understand the biology of the neoplastic lesions of prostate.

Combined effects of radiotherapy and photodynamic therapy on an in vitro human prostate model

84%

Colasanti A., Kisslinger A., Quarto M., Riccio P.

Acta Biochimica Polonica

2004

tom 51

nr 4

Human prostate cancer cells were evaluated for growth after photodynamic therapy, radiotherapy, and combined treatment. Indocyanine green was tested as a photosensitizer and radiosensitizer. Two human cell lines were used: PC-3 derived from prostate carcinoma, and EPN derived from normal prostate tissue. The light source used for the photoactivation experiments was a diode laser peaked at 805 nm. The light dose incident on cells was 108 J/cm2. Ionizing radiation was produced by a linear accelerator, and the dose was 2, 4 and 6 Gy. Cytotoxicity was evaluated by measuring the colony forming ability of cells. Our results show that indocyanine green induces cell death by photoactivation, but it does not act as a radiosensitizer if used with ionizing radiation. The combined treatment of photodynamic therapy and radiotherapy produces an additive effect which does not depend on the sequence of the two treatments. Combined treatments could be more useful since they allow the reduction of the ionizing radiation

Basal cell subpopulation as putative human prostate carcinoma stem cells

84%

Kuzmanov A., Hayrabedyan S., Karaivanov M., Todorova K.

Folia Histochemica et Cytobiologica

2007

tom 45

nr 2

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Cellular and Molecular Biology Letters

1 Folia Histochemica et Cytobiologica

1 Brys M.

1 Colasanti A.

1 Hayrabedyan S.

1 Karaivanov M.

1 Kisslinger A.

1 Krajewska W. M.

1 Kuzmanov A.

1 Quarto M.

1 Riccio P.

1 Todorova K.

1 2007

1 2004

1 1997

Wyniki wyszukiwania

Potential suppressor gene loci and human prostate neoplasms

Combined effects of radiotherapy and photodynamic therapy on an in vitro human prostate model

Basal cell subpopulation as putative human prostate carcinoma stem cells