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The ability of zinc-binding proteins from boar seminal plasma to bind heparin and phosphorylcholine

100%

Mogielnicka-Brzozowska M., Strzezek J., Dziekonska A., Kordan W.

Animal Science Papers and Reports

2014

tom 32

nr 4

Zinc-binding proteins (ZnBPs) isolated from boar seminal plasma exert multiple effects on boar spermatozoa. The aim of this study was to determine whether the isolated zinc-binding proteins were capable of binding additional ligands. The affinity chromatography method was used for the first time to demonstrate that boar ZnBPs show affinity for both heparin (hep) and phosphorylcholine (pch). ZnBPs+hep accounted for approximately 20%, and ZnBPs+pch – for approximately 45% of total ZnBPs. Predominant polypeptides with molecular mass form 6.5 to 14 kDa were observed in both groups (ZnBPs+hep, ZnBPs+pch). The analyzed peptides’ low molecular mass and their ability to bind zinc ions as well as heparin and phosphorylcholine suggest that they belong to the family of multifunctional boar spermadhesins which perform their functions in the fertilization process by binding more than one ligand. The results indicate that the ZnBPs of boar seminal plasma may be involved in the processes associated with oocyte fertilization not only by zinc ions binding but also through heparin and phosphorylcholine.

Azurocidin - inactive serine proteinase homolog acting as a multifunctional inflammatory mediator

84%

Watorek W.

Acta Biochimica Polonica

2003

tom 50

nr 3

Azurocidin, also known as cationic antimicrobial protein 37 kDa (CAP37) or heparin-binding protein (HBP) is an inactive homolog of serine proteinases residing in granulocytes. The ability to cleave peptide bond was lost due to replacement of two of the three residues from the conserved catalytic triad characteristic for serine protein- ases. Azurocidin has a broad spectrum of antimicrobial activity, mainly against Gram-negative bacteria. It is also recognized as a multifunctional inflammatory mediator for its contracting effects on endothelial cells causing an increase of vascular permeability, capacity to bind endotoxin and ability to attract monocytes to inflammation sites.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Animal Science Papers and Reports

1 Dziekonska A.

1 Kordan W.

1 Mogielnicka-Brzozowska M.

1 Strzezek J.

1 Watorek W.

1 2014

1 2003

Wyniki wyszukiwania

The ability of zinc-binding proteins from boar seminal plasma to bind heparin and phosphorylcholine

Azurocidin - inactive serine proteinase homolog acting as a multifunctional inflammatory mediator