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1

The evaluation of quantity and distribution of murine pulmonary mast cells in experimental hemorrhagic shock

100%
Kasacka I., Humenczyk-Zybala M., Niczyporuk M., Mycko G.
Folia Histochemica et Cytobiologica
|
2003
|
tom 41
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nr 2
2
Content available remote

Involvement of the cholinergic system in the central histamine-induced reversal of critical haemorrhagic hypotension in rats

86%
Yalcin M., Savci V., Jochem J.
Journal of Physiology and Pharmacology
|
2009
|
tom 60
|
nr 2
133-137
Histamine, acting centrally as a neurotransmitter, evokes a reversal of haemorrhagic shock in rats due to the activation of the sympathetic and the renin-angiotensin systems as well as the release of arginine vasopressin and proopiomelanocortin-derived peptides. In the present study, we demonstrate influences of cholinergic receptor antagonists on the central histamine-induced resuscitating action. Experiments were carried out in male anaesthetised Wistar rats subjected to a haemorrhagic hypotension of 20-25 mmHg, resulting in the death of all control animals within 30 min. Histamine (100 nmol) administered intracerebroventricularly (icv) at 5 min of critical hypotension produced a long-lasting pressor effect with increases in heart rate and peripheral blood flows, and a 100% survival at 2 h. Mean arterial pressure and blood flow changes were almost completely blocked by nicotinic receptor antagonist mecamylamine (246.3 nmol; icv) and partially inhibited by muscarinic receptor blocker atropine sulphate (14.8 nmol; icv). Cholinergic receptor antagonists given alone in the control saline-treated groups did not affect cardiovascular parameters in the post-bleeding period. In conclusion, there are interactions between the histaminergic and cholinergic systems, with an involvement of both nicotinic and muscarinic receptors, in the central cardiovascular regulation in haemorrhagic hypotension in rats.
3
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A novel, potent and selective inhibitor of the activity of inducible nitric oxide synthase [GW274150] reduces the organ injury in hemorrhagic shock

86%
McDonald M. C., Izumi M., Cuzzocrea S., Thiemermann C.
Journal of Physiology and Pharmacology
|
2002
|
tom 53
|
nr 4,1
An enhanced formation of nitric oxide (NO) by the inducible NO synfhase (iNOS) may contribute to the pathophysiology of hemorrhagic shock. This study investigates the effect of a novel, potent and selective inhibitor of iNOS activity (GW274150) on the circulatory failure and the organ injury and dysfunction associated with hemorrhagic shock in the anesthetised rat. Hemorrhage (sufficient to lower mean arterial blood pressure to 45 mmHg for 90 min) and subsequent resuscitation with shed blood resulted (within 4 h after resuscitation) in a delayed fall in blood pressure, renal and liver injury and dysfunction as well as the pancreatic injury. Pre-treatment of rats with GW274150 (5 mg/kg at 30 min prior to the onset of hemorrhage) attenuated the renal dysfunction as well as the liver and pancreatic injury caused by hemorrhage and resuscitation. Interestingly, GW274150 did not reduce the delayed fall in blood pressure associated with hemorrhagic shock. We propose that an enhanced formation of NO from iNOS contributes to the organ injury and dysfunction in hemorrhagic shock, and that highly selective inhibitors of iNOS activity, such as GW274150, may represent a novel therapeutic approach for the therapy of hemorrhagic shock.
4
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Central histamine-induced reversal of critical haemorrhagic hypotension in rats - haemodynamic studies

86%
Jochem J.
Journal of Physiology and Pharmacology
|
2002
|
tom 53
|
nr 1
Volume-controlled irreversible haemorrhagic shock in rats produced by blood withdrawal until stabilisation of critical mean arterial pressure (MAP)20-25 mmHg is associated with an extreme decrease in cardiac index (CI)and an increase in total peripheral resistance index (TPRI),with reductions in renal (RBF),hindquarters (HBF)and mesenteric blood flow (MBF),and leads to the death of all control animals within 30 min.Histamine (100 nmol)injected intracerebroventricularly (i.c.v.)in the early phase of critical hypotension produces a prompt and long-lasting increase in MAP and heart rate,with a 100%survival for 2 h after treatment.The effects are associated with the rise in the circulating blood volume and CI,and the decrease in TPRI,with the increase in RBF and HBF,and persistently lowered MBF.Both splenectomy and ligation of the suprahepatic veins inhibit histamine-induced increase in circulating blood volume as well as cardiac and regional haemodynamic effects.It can be concluded that histamine administered icv activates central endogenous compensatory mechanisms,which leads to the reversal of haemorrhagic shock conditions due to the mobilisation of blood from venous reservoirs,the increase in circulating blood volume and its redistribution.Moreover,histamine evokes the rises in CI and perfusion of the renal and skeletal muscle vascular regions.
5
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Cardiac and regional haemodynamic effects of endothelin-1 in rats subjected to critical haemorrhagic hypotension

86%
Jochem J., Zwirska-Korczala K., Gwozdz B., Walichiewicz P., Josko J.
Journal of Physiology and Pharmacology
|
2003
|
tom 54
|
nr 3
In the present study, we examined cardiac and regional haemodynamic effects of endothelin-1 (ET-1), a potent vasoconstrictive factor, in a rat model of pressure-controlled irreversible haemorrhagic shock resulting in the death of all control animals within 30 min. Experiments were carried out in male ethylurethane-anaesthetised Wistar rats subjected to hypotension of 20-25 mmHg, which resulted in bradycardia, an extreme decrease in cardiac index (CI) and an increase in total peripheral resistance index (TPRI), with reductions in renal (RBF), hindquarters (HBF) and mesenteric blood flow (MBF). ET-1 (50, 200 pmol/kg) administered intravenously at 5 min of critical hypotension produced increases in mean arterial pressure (MAP) and heart rate (HR), which were significantly higher than those in normotensive animals, and a 100% survival at 2 h after treatment. The effects were accompanied by a rise in CI, a decrease in TPRI, with increases in RBF and HBF and persistently lowered MBF, and an increase in circulating blood volume 20 min after treatment. The cardiovascular effects of ET-1 were inhibited by the ETA receptor antagonist BQ-123 (1 mg/kg), while the ETB receptor antagonist BQ-788 (3 mg/kg) had no effect. In conclusion, ET-1 acting via ETA receptors produces reversal of haemorrhagic hypotension in rats due to the mobilisation of blood from venous reservoirs, with the improvements in cardiac function and the perfusion of peripheral tissues.
6

BN52021 stabilizes the oxidant-antioxidant equilibrium in peritoneal lavage fluid in experimental hemorrhagic shock

86%
Debek W., Chyczewski L., Farbiszewski R.
Folia Histochemica et Cytobiologica
|
1999
|
tom 37
|
nr 4
7
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Content available

Partial purification and identification of cardiodepressant factor from the posterior pituitary lobe in rats

86%
Goraca A., Walkowiak B.
Journal of Physiology and Pharmacology
|
2000
|
tom 51
|
nr 1
8
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Content available

Cardiovascular effects of histamine administered intracerebroventricularly in critical haemorrhagic hypotension in rats

86%
Jochem J.
Journal of Physiology and Pharmacology
|
2000
|
tom 51
|
nr 2
9
Content available remote

Involvement of the renin-angiotensin system in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats

86%
Jochem J.
Journal of Physiology and Pharmacology
|
2004
|
tom 55
|
nr 1,1
The study was undertaken to examine the involvement of the renin-angiotensin system in the reversal by endogenous central histamine of critical haemorrhagic hypotension in anaesthetised Wistar rats. Histamine N-methyltransferase inhibitor metoprine (20 µg) administered intracerebroventricularly at 5 min of critical hypotension 20-25 mmHg produced increases in histamine concentrations as measured 20 min after treatment in the hypothalamus (581.33 ± 63.23 vs. 488.26 ± 56.34 ng/g of wet tissue; P < 0.01) and medulla oblongata (53.42 ± 14.65 vs. 34.68 ± 13.52 ng/g of wet tissue; P < 0.05). That was accompanied by 34.7% higher plasma angiotensin II concentration in comparison to the control group. Metoprine produced dose-dependent (5-20 µg) rises in mean arterial pressure (MAP) and heart rate, which were significantly higher than those in normotensive animals. The resuscitating action of metoprine (20 µg) was associated with rises in renal, mesenteric and hindquarters blood flows, and a 100% survival at 2 h after treatment, while in the saline-treated group, all the animals died within 30 min. Angiotensin type 1 (AT1) receptor antagonist ZD 7155 (0.5 mg/kg; iv) decreased regional vascular resistance and inhibited metoprine-induced increase in MAP, whereas AT2 receptor blocker PD 123319 (10 mg/kg; iv) had no effect. Angiotensin-converting enzyme inhibitor captopril (30 mg/kg; iv) reduced the increase in plasma angiotensin II level and the haemodynamic effects of metoprine. Neither capropril, nor angiotensin receptor antagonists influence the survival at 2 h after treatment. In conclusion, the renin-angiotensin system is involved in central histamine-induced resuscitating action in rats.
10

Influence of brain hypoxia on megakaryocytic emperipolesis in rats

86%
Chyczewski L., Debek W., Dzieciol J., Kirejczyk J. K., Niklinski J., Sulkowski S.
Folia Histochemica et Cytobiologica
|
1994
|
tom 32
|
nr 3
11
Content available remote

The role of serotonergic 5-HT1A receptors in central cardiovascular regulation in hemorrhagic shock in rats

72%
Sowa P., Adamczyk-Sowa M., Zwirska-Korczala K., Namyslowski G., Misiolek M., Pierzchala K.
Journal of Physiology and Pharmacology
|
2013
|
tom 64
|
nr 2
12
Content available remote

Proopiomelanocortin but not vasopressin or renin-angiotensin system induces resuscitative effects of central 5-HT1A activation in haemorrhagic shock in rats

72%
Sowa P., Adamczyk-Sowa M., Zwirska-Korczala K., Pierzchala K., Adamczyk D., Paluch Z., Misiolek M.
Journal of Physiology and Pharmacology
|
2014
|
tom 65
|
nr 5
13
Content available remote

Cardiovascular effects of centrally acting orexin A in haemorrhage-shocked rats

72%
Jochem J., Zwirska-Korczala K., Zabielski R., Kato I., Kuwahara A.
Journal of Physiology and Pharmacology. Supplement
|
2006
|
tom 57
|
nr 11
115-124
Orexin A influences the central cardiovascular regulation, since after intracerebroventricular (icv) administration it evokes short-lasting increases in mean arterial pressure (MAP) and heart rate (HR) in normotensive animals. The aim of the present study was to examine haemodynamic effects of orexin A in haemorrhage-shocked rats. Experiments were carried out in anaesthetized Wistar rats subjected for a critical irreversible haemorrhagic hypotension of 20-25 mmHg, which resulted in the death of all saline icv-treated control animals within 30 min. Orexin A (0.5-1.5 nmol; icv) administered at 5 min of critical hypotension evoked dose-dependent long-lasting increases in MAP, HR and renal, mesenteric and hindquarters blood flows, with a 100% survival of 2 h after treatment (1.5 nmol; icv). Changes in MAP and peripheral haemodynamics were inhibited by intravenous pretreatment with alpha1- and alpha2-adrenoceptor antagonists prazosin (0.5 mg/kg) and yohimbine (1.0 mg/kg), respectively. Moreover, both antagonists significantly decreased the survival rate to 16.6 and 33.3% (P<0.05 vs. orexin A [1.5 nmol]-treated group). In contrast, ß-adrenoceptor antagonist propranolol (1.0 mg/kg) completely blocked orexin A-induced HR changes, without influence on MAP, peripheral blood flows and the survival rate. Therefore, we conclude that centrally acting orexin A evokes the resuscitating effect in haemorrhage-shocked rats due to the activation of the sympathetic nervous system.
14
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Involvement of the histaminergic system in cytidine 5'-diphosphocholine-induced reversal of critical haemorrhagic hypotension in rats

72%
Jochem J., Savci V., Filiz N., Rybus-Kalinowska B., Fogel W. A., Yalcin M.
Journal of Physiology and Pharmacology
|
2010
|
tom 61
|
nr 1
37-43
Cytidine 5’-diphosphocholine (CDP-choline) is an endogenously synthesized mononucleotide which exerts a variety of physiological effects by altering central cholinergic transmission. Administered intracerebroventricularly (i.c.v.) or intravenously, it reverses haemorrhagic hypotension in rats, apparently by the activation of central cholinergic receptors. The study was undertaken to investigate the involvement of the central histaminergic system in CDP-choline-mediated reversal of haemorrhagic hypotension. Experiments were carried out in male ketamine/xylazine-anaesthetised Wistar rats subjected to haemorrhagic hypotension of 20-26 mmHg. CDP-choline (2 µmol; i.c.v.) administered at 5 min of critical hypotension produced a long-lasting pressor effect with increases in mean arterial pressure (MAP), heart rate (HR), and renal, hindquarters and mesenteric blood flows, resulting in a 100% survival at 2 h. The action was accompanied by approximately a 26% increase in extracellular histamine concentration at the posterior hypothalamus, as measured by microdialysis. Cardiovascular effects mediated by CDP-choline were almost completely blocked by pretreatment with H1 receptor antagonist chlorpheniramine (50 nmol; i.c.v.), but not with H2 receptor blocker ranitidine (25 nmol; icv) or H3/H4 receptor antagonist thioperamide (50 nmol; i.c.v.). In conclusion, the present results show that the central histaminergic system, through the activation of H1 histaminergic receptors, is involved in CDP-choline-induced resuscitating effect in haemorrhage-shocked rats.
15
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Involvement of the histaminergic system in the resuscitating effect of centrally acting leptin in haemorrhagic shock in rats

72%
Jochem J., Altinbas B., Yalcin M., Ottani A., Giuliani D., Savci V., Kasperska-Zajac A., Guarini S.
Journal of Physiology and Pharmacology
|
2016
|
tom 67
|
nr 1
16
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Content available

The effects of increased inspired oxygen with and without dopamine on lung and diaphragm hydrogen peroxide and apoptosis following hemorrhagic shock

72%
Mach W. J., Thimmesch A. R., Slusser J. G., Clancy R. L., Pierce J. D.
Journal of Pre-Clinical and Clinical Research
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2010
|
tom 04
|
nr 1
17
Content available remote

Involvement of proopiomenalocortin-derived peptides in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats

72%
Jochem J.
Journal of Physiology and Pharmacology
|
2004
|
tom 55
|
nr 1,1
An increase in endogenous central histamine concentrations, after loading with histamine precursor L-histidine or inhibition of histamine N-methyltransferase (HNMT) activity, produces the reversal of critical hypotension with improvement in survival of haemorrhage-shocked rats. In the present study, the involvement of proopiomelanocortin (POMC)-derived peptides in central histamine-induced resuscitating action was examined in male anaesthetised Wistar rats subjected to a haemorrhagic hypotension of 20-25 mmHg resulting in the death of all control animals within 30 min. HNMT inhibitor metoprine (20 µg) administered intracerebroventricularly (icv) at 5 min of critical hypotension produced a long-lasting pressor effect with a 100% survival rate at 2 h. The action was accompanied by 34.5% and 28.9% higher plasma concentrations of ACTH and alpha-MSH, respectively, in comparison to concentrations in the saline-injected group as measured 20 min after treatment. Melanocortin type 4 (MC4) receptor antagonist HS014 (5 µg; icv) inhibited metoprine-induced increase in mean arterial pressure, which resulted from decreased regional vascular resistance, however, it did not affect the heart rate and the survival at 2 h. On the other hand, glucocorticoid type II receptor blocker mifepristone (30 mg/kg; sc) had no effect. In conclusion, POMC-derived peptides, acting centrally via MC4 receptors, participate in endogenous central histamine-induced resuscitating effect in rats.
18
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Content available

The evaluation of murine pleural lavage fluid cellular composition in experimental hemorrhagic shock with special regard to mast cells morphometry

72%
Kasacka I., Humenczyk-Zybala M., Debek W., Chyczewski L., Niczyporuk M., Mycko G.
Journal of Physiology and Pharmacology
|
2001
|
tom 52
|
nr 2
19
Content available remote

Role of endocannabinoids in cardiovascular shock

58%
Malinowska B., Lupinski S., Godlewski G., Baranowska U., Schlicker E.
Journal of Physiology and Pharmacology. Supplement
|
2008
|
tom 59
|
nr 8
20
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Increase in cardiodepressant factor release from the posterior pituitary lobe after angiotensin II infusion into the internal carotid artery

58%
Goraca A., Traczyk W. Z.
Journal of Physiology and Pharmacology
|
1997
|
tom 48
|
nr 2
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