Wyniki wyszukiwania

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Ingestion capacity of PMN cells in peripheral blood of rabbits experimentally infected with VHD (viral haemorrhagic disease) virus strains originating from various biotopes

100%

Tokarz-Deptula B., Hukowska B., Deptula W.

Polish Journal of Veterinary Sciences

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2003

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tom 06

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nr 4

2

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Characteristics of a new variant of rabbit haemorrhagic disease virus – RHDV2

100%

Bebnowska D., Niedzwiedzka-Rystwej P.

Acta Biologica

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2019

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tom 26

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Analysis of the fragment of capsid protein gene sequences of Polish strains of European brown hare syndrome virus

100%

Chrobocinska M.

Bulletin of the Veterinary Institute in Puławy

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2002

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tom 46

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nr 2

4

BTV-vector-host interaction: the epidemiological triangle in disease transmission

80%

Niedbalski W.

Medycyna Weterynaryjna

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2018

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tom 74

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nr 11

Understanding the interaction between the bluetongue virus (BTV), the Culicoides vector and the ruminant host is essential to control bluetongue (BT). This triangle of interaction can be understood individually at the level of the virus, the level of vector and the host level. BTV-vector-host interactions involve physiological and ecological mechanisms, and they have evolved under a specific set of environmental conditions. Recent advances in understanding this interaction include increased knowledge of the virus replication cycle, BTV immunology and pathogenesis in the vertebrate host, as well as the virulence and pathogenicity features of newly discovered BTV serotypes. To understand the virus-host-vector interaction, new molecular biology techniques and experimental infection biology methods have been widely used. The next-generation sequencing, the establishment of a reverse genetics system for the virus, and development of novel infection models and refinement of the existing BTV experimental infection methodologies have proven very helpful. This progress in biotechnology has also made it possible to develop new-generation BTV vaccines, such as disabled infectious single cycle (DISC) vaccines and disabled infectious single animal (DISA) vaccines. However, several questions still need to be answered, such as those concerning cellular pathways involved in the induction of innate immunity and the function of NS4 in the BTV replication cycle. In addition, the identities of specific molecular determinants and the role of quasi-species diversity in determining BTV phenotype are still unclear and should be better explained.

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Identification of Polish RHDVa subtype strains based on the analysis of a highly variable part VP60 gene

80%

Fitzner A., Niedbalski W., Paprocka G., Kesy A.

Polish Journal of Veterinary Sciences

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2012

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tom 15

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nr 1

In order to determine the genetic variability of Polish RHD virus strains and to confirm the presence of genetic variant (RHDVa) subtype the partial nucleotide sequences of capsid protein gene, including two highly variable regions C and E, were examined. Phylogenetic analyses of 15 viral strains obtained over 18 years revealed the presence of three genetic groups. The oldest RHDV strains exhibit very close amino acid sequence similarity (98-99%) to the German FRG89 reference strain and most of European strains of the same period, as well as Chinese isolate from 1984. The HA-negative strains and isolates with variable reactivity in the HA test belong to the second subgroup and exhibit an intermediate level of variability (about 3%) in the analysed VP60 gene fragment. The most genetically variable strains (6-7%) clustered to RHDVa subtype. The analysis of nucleotides and amino acid sequences demonstrated three pairs of well conserved RHDV strains, isolated over 3, 6 and 10-year period.

Ograniczanie wyników

2 Polish Journal of Veterinary Sciences

1 Acta Biologica

1 Bulletin of the Veterinary Institute in Puławy

1 Medycyna Weterynaryjna

2 Niedbalski W.

1 Bebnowska D.

1 Chrobocinska M.

1 Deptula W.

1 Fitzner A.

1 Hukowska B.

1 Kesy A.

1 Niedzwiedzka-Rystwej P.

1 Paprocka G.

1 Tokarz-Deptula B.

1 2019

1 2018

1 2012

1 2003

1 2002

Ingestion capacity of PMN cells in peripheral blood of rabbits experimentally infected with VHD (viral haemorrhagic disease) virus strains originating from various biotopes

Characteristics of a new variant of rabbit haemorrhagic disease virus – RHDV2

Analysis of the fragment of capsid protein gene sequences of Polish strains of European brown hare syndrome virus

BTV-vector-host interaction: the epidemiological triangle in disease transmission

Identification of Polish RHDVa subtype strains based on the analysis of a highly variable part VP60 gene