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Studies on haemolytic properties of puffer fishes from South East Coast of India

100%

Mohan Raj M., Bragadeeswaran S., Suguna A.

International Letters of Natural Sciences

2015

tom 03

Marine fishes play an important role for health care. The objectives of the present study was to evaluate the haemolytic activity of crude extracts of six puffer fishes Cyclichthys orbicularis, Diodon holocanthus, Canthigaster solandri, Arthron hispidus, A. inermis and Lagocephalua inermis collected from Parangipettai, Tamil Nadu, South East Coast of India. The haemolytic activity was tested against red blood cells (RBCs) of chicken, goat and human blood. The haemolytic activity was high in chicken blood (128HU) against of Cyclichthys orbicularis and A. inermis and minimum (16HU) in Lagocephalua inermis. In goat erythrocytes the highest haemolytic activity (256HU) against Arthron hispidus and minimum (16HU) against A. inermis and Lagocephalua inermis were observed. In human erythrocytes the maximum haemolytic activity of 32HU against Cyclichthys orbicularis, Arthron hispidus were recorded. In blood agar plate assay the highest zone of inhibition of 6.4±0.9 and 6.3±0.1 mm were observed in A. inermis against chicken erythrocytes and Arthron hispidus against goat erythrocytes respectively. The results strongly suggest that, the Marine puffer fish extracts showed good cytolytic properties against blood RBCs.

The effect of oleanolic and ursolic acids on the hemolytic properties and biofilm formation of Listeria monocytogenes

86%

Kurek A., Markowska K., Grudniak A. M., Janiszowska W., Wolska K. I.

Polish Journal of Microbiology

2014

tom 63

nr 1

Oleanolic acid and ursolic acid are pentacyclic triterpenoids isolated from a variety of medicinal plants, which have antibacterial activity. Listeria monocytogenes is a Gram-positive facultative pathogen, being the causative agent of listeriosis. The present study was carried out to evaluate the in vitro effect of sub-inhibitory concentrations of both triterpene acids on the pathogenicity determinants of L. monocytogenes: their hemolytic activity and biofilm forming ability. Oleanolic and ursolic acids inhibited listeriolysin O activity without influencing toxin secretion. Biofilm formation, and the viability of L. monocytogenes cells in biofilms was diminished by both compounds. Thus, both acids affected L. monocytogenes virulence. It was also demonstrated that oleanolic acid bound to the peptidoglycan of L. monocytogenes and this interaction was influenced by teichoic acids.

Hematological and antifungal properties of temporin A and a cecropin A-temporin A hybrid

72%

Wade D., Silveira A., Rollins-Smith L., Bergman T., Silberring J., Lankinen H.

Acta Biochimica Polonica

2001

tom 48

nr 4

Temporin A (TA) and a cecropin A-temporin A hybrid peptide (CATA) were synthesized and assayed for their hemolytic, anticoagulant, and antifungal properties. CATA retains significant antifungal activity, is less hemolytic than TA, and inhibits blood coagulation. These results recommend further studies of the biological activities of CATA.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 International Letters of Natural Sciences

1 Polish Journal of Microbiology

1 Bergman T.

1 Bragadeeswaran S.

1 Grudniak A. M.

1 Janiszowska W.

1 Kurek A.

1 Lankinen H.

1 Markowska K.

1 Mohan Raj M.

1 Rollins-Smith L.

1 Silberring J.

1 Silveira A.

1 Suguna A.

1 Wade D.

1 Wolska K. I.

1 2015

1 2014

1 2001

Wyniki wyszukiwania

Studies on haemolytic properties of puffer fishes from South East Coast of India

The effect of oleanolic and ursolic acids on the hemolytic properties and biofilm formation of Listeria monocytogenes

Hematological and antifungal properties of temporin A and a cecropin A-temporin A hybrid