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1
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Into the unknown - the death pathways in the neonatal gut epithelium

100%
Godlewski M. M., Slupecka M., Wolinski J., Skrzypek T., Skrzypek H., Motyl T., Zabielski R.
Journal of Physiology and Pharmacology. Supplement
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2005
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tom 56
|
nr 3
7-24
Apoptosis is a fundamental process in the development of the fast growing intestinal mucosa. Apoptotic cells are present along the whole length of the villi and in the crypts. The mechanisms involved in the induction of apoptosis in the gut mucosa are still unknown. Cytokines are believed to play a role in auto- and paracrine models because the cells are dying in so-called "packets" containing neighboring cells. In the rapidly developing gut of neonates, the apoptosis rate is transiently reduced in the first days of life, enhancing the growth of mucosa. Afterwards, apoptosis plays a role in the exchange of the enterocyte population, facilitating maturation of the mucosa. The presence of autophagic cells has been confirmed for the first time in the developing gut. Deprivation of growth factors during feeding artificial milk formula led to an increased apoptosis rate. Supplementation with leptin reduced cell apoptosis and increased the mitosis-to-apoptosis ratio. Autophagy was also diminished. The key to healthy gut mucosa growth in early life, especially in fast-growing animals, is colostrum, which supplies nutritional and defensive components together with supplementary growth factors, cytokines and hormones essential for growth and maturation of gut mucosa.
2
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Intestinal MMC-related electric fields and pancreatic juice control the adhesion of gram-positive and gram-negative bacteria to the gut epithelium - in vitro study

80%
Jankowska A., Wrzesinski M., Laubitz D., Kazimierczak W., Skrzypek H., Bardowski J., Zabielski R., Grzesiuk E.
Journal of Physiology and Pharmacology
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2008
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tom 59
|
nr 4
795-810
The adhesion of six different Lactobacillus and Lactococcus and three pathogenic Escherichia and Salmonella strains was studied using Caco-2 cell line. In this in vitro model system the influence of weak electric field (EF) on bacterial adhesion was tested. The EF source was the in vitro reconstruction of spiking potentials recorded in the duodenum of a healthy calf during one myoelectrical migration complex (MMC) cycle. The ability to adhere to Caco-2 cells of bacteria belonging to two groups, Gram-positive lactobacilli and lactococci, and Gram-negative Escherichia and Salmonella differed considerably. The pathogenic bacteria adhered better to well-differentiated Caco-2 cells whereas lactobacilli and lactococci displayed better adhesion to non-differentiated Caco-2 cells. In the presence of MMC-related EF an increased adhesion of Lactobacillus and Lactococcus but not of Salmonella enterica s. Enteritidis and E. coli 269 to Caco-2 cells was observed. Two later strains adhered even less in the presence of EF. The same tendency was found in the presence of pancreatic juice in a cell medium. In conclusion, the myoelectric component of the small intestinal motility, the MMC-related EF, and pancreatic juice may increase the ability of lactic acid bacteria to adhere to GI epithelial cells, creating better environmental conditions for colonization of the intestine and competition with Gram-negative pathogens.
3
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Light and scanning electron microscopy evaluation of the postnatal small intestinal mucosa development in pigs

80%
Skrzypek T., Valverde Piedra J. L., Skrzypek H., Wolinski J., Kazimierczak W., Szymanczyk S., Pawlowska M., Zabielski R.
Journal of Physiology and Pharmacology. Supplement
|
2005
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tom 56
|
nr 3
71-87
Modifications in the structure of gastrointestinal mucosa is often used to evaluate gut function for instance during the development or in response to particular food components. Scanning electron microscopy (SEM) gives a chance to observe the surface of the gut epithelium in three dimensions. However, this technique is seldom used due to technical difficulties. The present study attempted to investigate the intestinal mucosa structure changes in the postnatal pig using light and scanning electron microscopy technique. Experiments were carried out on sow reared piglets from birth until 38 days of age. Piglets were sacrificed at birth and at the 3rd, 7th, 21st and 38th day of life. The entire gastrointestinal tract was immediately harvested and the whole thickness tissue samples were taken from the duodenum, jejunum and ileum for optical and scanning electron microscopy. SEM analyses corroborated with histometry made by optical microscopy. Moreover, a number of shape modifications of the villi and its surface have been observed. The development changes in small intestine mucosa during the first 3 weeks were manifested in shape, size and density of villi. In conclusion, the structure of small intestinal mucosa undergoes profound structural changes. SEM gives a new dimension in the investigation of gut mucosa.
4
Content available remote

Molecular mechanism of programmed cell death in the gut epithelium of neonatal piglets

80%
Godlewski M. M., Hallay N., Bierla J. B., Zabielski R.
Journal of Physiology and Pharmacology. Supplement
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2007
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tom 58
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nr 3
97-113
5

Potassium ion transporting ATPase activities in insect cells: elektrophysiology, biochemistry and molecular biology

61%
Djamgoz M. B. A., Billingsley P. F., Emery A. M., Fitzgerald E. M., MacVicker J. A. K., Pickard B., Ready P. D.
Biophysics of Membrane Transport
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1992
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tom 11
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nr 1
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