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Effects of peripheral or central GLP-1 receptor blockade on leptin-induced suppression of appetite

100%

Nowak A., Bojanowska E.

Journal of Physiology and Pharmacology

2008

tom 59

nr 3

501-510

Leptin and glucagon-like peptide-1 (GLP-1) were proved to act in concert to control the activity of feeding centres. Since leptin receptor was identified in the gut endocrine L cells and neurons producing GLP-1, we have checked whether GLP-1 mediates the effects of leptin on feeding and drinking behaviour. To this aim, an intraperitoneal or intracerebroventricular injection of exendin (9 - 39), a GLP-1 antagonist, (50 or 10 µg per rat, respectively) followed by leptin (100 or 5 µg per rat, respectively) was made and 24-hour food intake and body weight changes were measured. Previous injection of exendin (9 - 39) completely abolished the suppressory effect of peripheral leptin on food intake and body weight gain. Moreover, exendin (9 - 39) significantly attenuated the effect of intracerebroventricular leptin on food but not water consumption. It is concluded that intact GLP-1 signalling is necessary to mediate the effect of leptin on food intake in the rat. Conversely, leptin seems to affect the thirst center function independently of GLP-1. Also, these findings produce further evidence for close interactions between long- and short-term factors regulating the activity of feeding centres.

Metabolic cardio- and reno-protective effects of empagliflozin in a prediabetic rat model

80%

Huttl M., Markova I., Miklankova D., Oliyarnyk O., Trnovska J., Kucera J., Sedlacek R., Haluzik M., Malinska H.

Journal of Physiology and Pharmacology

2020

tom 71

nr 5

Combined stimulation of glucagon-like peptide-1 receptor and inhibition of cannabinoid CB1 receptor act synergistically to reduce food intake and body weight in the rat

80%

Bojanowska E., Radziszewska E.

Journal of Physiology and Pharmacology

2011

tom 62

nr 4

Ograniczanie wyników

3 Journal of Physiology and Pharmacology

2 Bojanowska E.

1 Haluzik M.

1 Huttl M.

1 Kucera J.

1 Malinska H.

1 Markova I.

1 Miklankova D.

1 Nowak A.

1 Oliyarnyk O.

1 Radziszewska E.

1 Sedlacek R.

1 Trnovska J.

1 2020

1 2011

1 2008

Wyniki wyszukiwania

Effects of peripheral or central GLP-1 receptor blockade on leptin-induced suppression of appetite

Metabolic cardio- and reno-protective effects of empagliflozin in a prediabetic rat model

Combined stimulation of glucagon-like peptide-1 receptor and inhibition of cannabinoid CB1 receptor act synergistically to reduce food intake and body weight in the rat