Wyniki wyszukiwania

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Erythropoietin affects GABAergic transmission in hippocampal neurons in vitro

100%

Wojtowicz T., Mozrzymas J. W.

Cellular and Molecular Biology Letters

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2008

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tom 13

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nr 4

649-655

Erythropoietin is a potent regulator of erythropoiesis. It acts via the specific membrane receptor (EpoR). Erythropoietin is also known to be present in the central nervous system, and its concentration and the expression of EpoR change during development, which raises the possibility that this modulator might be involved in the regulation of neuronal functions in the developing brain. The GABAergic system undergoes profound changes during development and is particularly susceptible to modulation by endogenous factors. Therefore, we decided to investigate the impact of Epo on GABAergic transmission in hippocampal neurons developing in vitro. An analysis of miniature IPSCs (mIPSCs) revealed that a long-term treatment with Epo (48 or 72 h) resulted in a major acceleration of the decaying phase of these currents while the amplitude and current frequency remained unchanged. Interestingly, this effect was restricted to the youngest considered age group (6-8 DIV), indicating that Epomediated modulation of mIPSCs depends on the developmental stage of the neurons. We conclude that Epo may exert a modulatory action on GABAergic transmission in developing neural networks.

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Orexin A reverses propofol and thiopental induced cytoskeletal rearrangement in rat neurons

84%

Turina D., Gerhardsson H., Bjornstrom K.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 4

3

The effects of baclofen on the feeding behaviour and body weight of vagally stimulated rats

84%

Krolczyk G., Laskiewicz J., Sobocki J., Matyja A., Kolasinska-Kloch W., Thor P. J.

Journal of Physiology and Pharmacology

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2005

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tom 56

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nr 1

It is hypothesised that the GABA(B) receptor agonist baclofen increases or has no effect on food intake, and electrical stimulation of vagal nerves decreases food intake. The aim of this study was to evaluate the effects of baclofen in vagally stimulated rats. Material and methods: Thirty two Wistar rats were divided into five groups: group A scheduled for microchip implantation for vagal stimulation, group B for sham operation, group C for microchip implantation and baclofen medication, group D for baclofen medication only and group E for gastric motility evaluation under influence of baclofen. The following parameters were then evaluated: food intake and body mass, gastric motility, leptin, insulin, and glucose serum levels. Results: In the comparison of groups B and A, daily food intake and body weight gain decreased by 17% (p<0.05) and by 22% (p<0.05), respectively. Baclofen alone (group D) did not significantly change either food intake nor diurnal body weight compared to the controls, but when used in conjunction with the microchip (group C) it did significantly reduce effect of vagal neuromodulation (p<0.05). Furthermore, a significant decrease in leptin and glucose levels was detected in group C: 677 to 165 pg/ml (p<0.05) and 5,93 to 4,88 mmol/l (p<0.05), respectively. The administration of baclofen stimulated significantly gastric motility and elicited irregular motor migrating complex (327±200 against control 255±52 cmH2O/s). Conclusions: These results suggest that microchip vagal neuromodulation through increased vagal afferent activity induces an alteration in the feeding behaviour and decreases nocturnal food intake and body weight. These effects were partially attenuated by baclofen. The data suggests that GABA(B) receptors play an important role in the pathomechanism of attenuation of food intake induced by vagal nerve stimulation.

4

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In vitro effects of fipronil on neuronal excitability in mammalian and molluscan nervous systems

67%

Varro P., Gyori J., Vilagi I.

Annals of Agricultural and Environmental Medicine

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2009

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tom 16

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nr 1

71-77

Ograniczanie wyników

2 Journal of Physiology and Pharmacology

1 Annals of Agricultural and Environmental Medicine

1 Cellular and Molecular Biology Letters

1 Bjornstrom K.

1 Gerhardsson H.

1 Gyori J.

1 Kolasinska-Kloch W.

1 Krolczyk G.

1 Laskiewicz J.

1 Matyja A.

1 Mozrzymas J. W.

1 Sobocki J.

1 Thor P. J.

1 Turina D.

1 Varro P.

1 Vilagi I.

1 Wojtowicz T.

1 2014

1 2009

1 2008

1 2005

Erythropoietin affects GABAergic transmission in hippocampal neurons in vitro

Orexin A reverses propofol and thiopental induced cytoskeletal rearrangement in rat neurons

The effects of baclofen on the feeding behaviour and body weight of vagally stimulated rats

In vitro effects of fipronil on neuronal excitability in mammalian and molluscan nervous systems