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Biochemical targets in filarial worms for selective antifilarial drug design

100%

Gupta S., Srivastava A. K.

Acta Parasitologica

2005

tom 50

nr 1

Filarial nematodes infect more than 150 million people worldwide and are responsible for diseases including elephantiasis, river blindness and tropical pulmonary eosinophilia. Antifílarial agents that can kill all the stages in the life cycle of causative filar- iae have yet to be developed. Very little effort has been made towards rational drug design, employing knowledge gained from studies of the biochemistry and physiology of filarial worms and of their interactions with their specific vertebrate hosts. In this review, we highlight the research and development of rational antifílarial agents and we discuss the pitfalls since the discovery of diethylcarbamazine, the only drug of choice for controlling filariasis, despite its adverse side effects.

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Evaluation of different Onchocerciass manifestation by age and gender among residents in selected endemic villages in Okigwe Local Government Area of Imo State, Nigeria

67%

Kamalu, N. A., Uwakwe F. E.

International Letters of Natural Sciences

2014

tom 15

nr 2

Aspects of human infection with Onchocerca volvulus was investigated in 9 villages in Okigwe LGA of Imo State, Nigeria between January 2010 and December 2011. The objectives were to compare the prevalence of different manifestations of Onchocerciasis according to gender and age, with view to determine if there had been a change in prevalence of Onchocerciasis among residents of some communities in Okigwe Local Government Area of Imo State. A cross sectional survey method was adopted for the study, blood free skin snips were collected from randomly selected consenting adults aged 5-62 years. Palpation for mobile subcutaneous lumps and clinical manifestation were observed among 960 persons comprising 511 males and 449 females. The commonest lesions observed were poor vision 17 %, nodules 15 %, leopard skin 20 %, lizard skin 15 %, and hanging groin 3 %. Musculo-skeletal pain (MSP) was recorded as one of the major complaints by 30 % of the subjects. The result showed that Onchocerciasis clinical manifestations are still prevalent, however nodules prevalence reduced among the sampled population (69.8 %).

Ograniczanie wyników

1 Acta Parasitologica

1 International Letters of Natural Sciences

1 Gupta S.

1 Kamalu, N. A.

1 Srivastava A. K.

1 Uwakwe F. E.

1 2014

1 2005

Wyniki wyszukiwania

Biochemical targets in filarial worms for selective antifilarial drug design

Evaluation of different Onchocerciass manifestation by age and gender among residents in selected endemic villages in Okigwe Local Government Area of Imo State, Nigeria