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RhTSG-6 inhibits IL-1beta-induced extracellular matrix degradation and apoptosis by suppressing the p38, and JNK pathways in nucleus pulposus cells

100%

Pei S., Ying J., Zhand Y., Su L., Cheng S., Ruan D.

Folia Histochemica et Cytobiologica

2020

tom 58

nr 3

Doxycycline down-regulates matrix metalloproteinase expression and inhibits NF-kappaB signaling in LPS-induced PC3 cells

80%

Ogut D., Reel B., Korkmaz C. G., Arun M. Z., Micili S. C., Ergur B. U.

Folia Histochemica et Cytobiologica

2016

tom 54

nr 4

Concentrations and activities of metalloproteinases 2 and 9 and their inhibitors (TIMPS) in chronic pancreatitis and pancreatic adenocarcinoma

80%

Lekstan A., Lampe P., Lewin-Kowalik J., Olakowski M., Jablonska B., Labuzek K., Jedrzejowska-Szypulka H., Olakowska E., Gorka D., Filip I., Dranka-Bojarowska D.

Journal of Physiology and Pharmacology

2012

tom 63

nr 6

The effect of doxycycline on atherogenesis in apoE-knockout mice

80%

Pawlowska M., Gajda M., Pyka-Fosciak G., Toton-Zuranska J., Niepsuj A., Kus K., Bujak-Gizycka B., Suski M., Olszanecki R., Jawien J., Korbut R.

Journal of Physiology and Pharmacology

2011

tom 62

nr 2

Doxycycline at subantimicrobial doses inhibits matrix metalloproteinases (MMPs) activity, and is the only MMP inhibitor which is widely available in clinical practice. The aim of the study was to reveal whether non-specific MMPs inhibition by tetracycline could ameliorate development of atherosclerosis in apolipoprotein E (apoE)-knockout mice. Doxycycline (1.5 mg/ kg b.w./day) administered orally attenuated atherogenesis, measured both by "en face" method (10.25±1.7% vs. 15.7±2.0%, p<0.05) and "cross-section" method (66,254±7,468 µm2 vs. 90,687±8,521 µm2, p<0.05). In-situ zymography showed decrease of the extent of non-specific gelatinase activity in doxycycline-treated mice This is the first report to date describing the effect of doxycycline on atherogenesis in apoE-targeted mice.

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Wyniki wyszukiwania

RhTSG-6 inhibits IL-1beta-induced extracellular matrix degradation and apoptosis by suppressing the p38, and JNK pathways in nucleus pulposus cells

Doxycycline down-regulates matrix metalloproteinase expression and inhibits NF-kappaB signaling in LPS-induced PC3 cells

Concentrations and activities of metalloproteinases 2 and 9 and their inhibitors (TIMPS) in chronic pancreatitis and pancreatic adenocarcinoma

The effect of doxycycline on atherogenesis in apoE-knockout mice