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The effect of fundectomy on pancreatic secretion in anaesthetized rats

100%

Matyjek R., Kapica M., Puzio I., Babelewska M., Zabielski R.

Journal of Physiology and Pharmacology. Supplement

2004

tom 55

nr 2

69-75

The aim of present study was to evaluate the influence of surgical fundectomy and exogenous leptin on the secretion of pancreatic juice in anesthetized rats. In male Wistar rats major part of the gastric fundus was surgically removed, and 60 days afterwards the external jugular vein and the pancreatic-biliary duct were catheterized under general anesthesia. The pancreatic-biliary juice (PBJ) was collected in 15 min intervals without introducing it into the duodenum. Intravenous leptin infusions (0.1, 1.0 and 10 µg/kg body weight) were made every 30 min. The same protocol was used in control non operated rats. The PBJ volume was significantly lower in fundectomized rats as compared to control rats and showed no significant effect to exogenous leptin. The PBJ protein output but not trypsin activity was lower in fundectomized rats as compared to control. Leptin reduced the PBJ protein and trypsin outputs in a dose-related manner in the control and experimental group. The inhibition was, however, more evident in the fundectomized rats. Plasma gastrin was higher in fundectomized rats, while plasma leptin and ghrelin were lower. In conclusion, fundectomy seems to reduce the non stimulated pancreatic secretion and modifies the response to leptin in anesthetized rats.

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Gastroprotection and control of food intake by leptin. Comparison with cholecystokinin and prostaglandins

80%

Konturek P. C., Konturek S. J., Brzozowski T., Hahn E. G.

Journal of Physiology and Pharmacology

1999

tom 50

nr 1

Ograniczanie wyników

1 Journal of Physiology and Pharmacology

1 Journal of Physiology and Pharmacology. Supplement

1 Babelewska M.

1 Brzozowski T.

1 Hahn E. G.

1 Kapica M.

1 Konturek P. C.

1 Konturek S. J.

1 Matyjek R.

1 Puzio I.

1 Zabielski R.

1 2004

1 1999

Wyniki wyszukiwania

The effect of fundectomy on pancreatic secretion in anaesthetized rats

Gastroprotection and control of food intake by leptin. Comparison with cholecystokinin and prostaglandins