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Inhibition of soluble epoxide hydrolase offers protection against fructose-induced diabetes and related metabolic complications in rats

100%

Shah S. A., Mehmood M. H., Khan M., Bukhari I. A., Alorainey B. I., Vohra F.

Journal of Physiology and Pharmacology

2020

tom 71

nr 5

Cytochrome P-450 monooxygenases in control of renal haemodynamics and arterial pressure in anaesthetized rats

67%

Kuczeriszka M., Badzynska B., Kompanowska-Jezierska E.

Journal of Physiology and Pharmacology. Supplement

2006

tom 57

nr 11

179-185

The renal regulatory role of cytochrome P450 dependent metabolites of arachidonic acid (AA), vasodilator epoxyeicosatrienoic acids (EETs) and vasoconstrictor 20-hydroxyeicosatetraenoic acid (20-HETE), was examined in anaesthetised rats. We measured renal artery flow (RBF), cortical (CBF) and medullary (MBF) perfusion (laser-Doppler) and medullary tissue nitric oxide (NO, selective electrode), after non-selective inhibition of CYP-450 pathway with 1-aminobenzotriazole (ABT, 10 mg/kg i.v.) or after selective inhibition of 20-HETE synthesis with HET0016 (Taisho Co, Yoshino-cho, Japan), infused into renal artery at 0.3 mg/kg/h or into renal medulla at rates increasing from 0.15 to 1.5 mg/kg/h. ABT caused significant (by 13.7%) decrease in RBF without changing MBF. Renal arterial HET0016 increased MBF (not RBF or CBF) from 152±12 to 174±12 perfusion units (+16%, P<0.001), while medullary tissue nitric oxide was significantly increased (P<0.001). After renal medullary HET0016, renal perfusion indices were significantly higher than after HET0016 solvent (ß-cyclodextrin). Total renal blood flow seems to be under vasodilator control of EETs whereas renal medullary perfusion under tonic suppression by 20-HETE. The data document, for the first in the whole kidney studies, the functional antagonism of 20-HETE and NO.

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Selective inhibition of arachidonic acid epoxidation in vivo

67%

Brand-Schieber E., Falck J. F., Schwartzman M.

Journal of Physiology and Pharmacology

2000

tom 51

nr 4,1

Ograniczanie wyników

2 Journal of Physiology and Pharmacology

1 Journal of Physiology and Pharmacology. Supplement

1 Alorainey B. I.

1 Badzynska B.

1 Brand-Schieber E.

1 Bukhari I. A.

1 Falck J. F.

1 Khan M.

1 Kompanowska-Jezierska E.

1 Kuczeriszka M.

1 Mehmood M. H.

1 Schwartzman M.

1 Shah S. A.

1 Vohra F.

1 2020

1 2006

1 2000

Wyniki wyszukiwania

Inhibition of soluble epoxide hydrolase offers protection against fructose-induced diabetes and related metabolic complications in rats

Cytochrome P-450 monooxygenases in control of renal haemodynamics and arterial pressure in anaesthetized rats

Selective inhibition of arachidonic acid epoxidation in vivo